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IV/PO, LLC
IV/PO, LLC is listed as a new startup research supplier in the Scientist.com network, with 1 site in 1 country.
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Sites
1
Countries
1
Services
What this research supplier says it provides, as listed in the Scientist.com network.
Type of company: New startup
Chemical and Compound Analysis
- Accelerator Mass Spectrometry Detect trace levels of naturally-occurring radionuclides and stable nuclides.
- API Physical Characteristics Characterize physical and chemical properties of new drug molecules to develop safe, effective, and stable dosage forms.
- Chemical Stability Measure the stability of small molecules in solution.
- GLP Small Molecule Bioanalysis Detect and analyze the pharmacokinetic profile of small molecules.
- High Resolution MS Elucidate the sequence and structure of peptides, proteins, biomarkers and organic compounds.
- Inductively Coupled Plasma-Mass Spectrometry (ICP-MS) Analysis Detect metals and several non-metals at concentrations as low as one part in 1015 (part per quadrillion, ppq) on non-interfered low-background isotopes.
Show all 14 in Chemical and Compound Analysis
- Ion Exchange Chromatography Separate and detect analytes.
- NMR Methods Use nuclear magnetic resonance spectroscopy to identify drug intermediates.
- NMR Structure Determine molecular structure, identify chemical impurities and validate sample integrity.
- Non GLP Small Molecule Bioanalysis Detect and analyze the pharmacokinetic profile of small molecules.
- Protein Binding HPLC Uses high pressure liquid chromatography to separate protein-drug complexes.
- Solution Nuclear Magnetic Resonance Identify molecular structure or impurities and assess product integrity of solution samples.
- Structural Chemistry Examine the relationship between protein structure and function.
- Structure Determination Determine the three-dimensional structure of proteins in the presence or absence of ligands.
Chemistry, Manufacturing and Controls (CMC)
- Chemistry, Manufacturing and Controls (CMC) Request Chemistry, Manufacturing and Controls services
Clinical Consulting
- Clinical Protocol Design & Development Creation of clinical protocol document which details how a clinical trial is designed, relating to to the methodology, hypothesis, and operation of clinical trial to ensure the safety of the patients is...
Clinical Trials
- Bioequivalence Studies Assess the expected biological equivalence of two proprietary preparations of a drug.
- Clinical Trial Design Develop study-related protocols, case report forms (CRFs) and database tools for records management.
Discovery Chemistry
- LCMS Analysis Physically separate substances using liquid chromatography and mass spectrometry.
Disease Models
- Diabetic Retinopathy Models Assess therapeutic efficacy of drug candidates in diabetic retinopathy models of disease.
- Infectious Disease Models Test therapeutic efficacy of drug candidate in infectious disease model.
- Inflammation Models Measure therapeutic endpoints in animal models for inflammation.
- Macular Degeneration Models Use a single animal species to create one or more models for eye disease.
Show all 65 services
Human Biological Samples
- Human Cell Lysates For requesting human Cell lysates.
- Human Fecal Matter Acquire fresh/frozen normal feces based on patient demographics and history.
- Human Peripheral Blood Mononuclear Cells (PBMCs) Acquire fresh/frozen normal PBMCs based on patient demographics and history.
- Human Plasma Acquire fresh/frozen human plasma
- Human Serum Acquire fresh/frozen normal serum based on patient demographics and history.
- Human Urine Acquire fresh/frozen normal urine based on patient demographics and history.
Show all 7 in Human Biological Samples
- Human Whole Organs Procure non-transplantable whole human organs or tissues, healthy or diseased, for medical research and development.
In Vitro ADME
- Cell Fractionation Isolate organelles and subcellular components.
- Compound Distribution Determine the metabolic fate of a drug candidate in tissue and organs of diseased and normal animal models.
- Conjugate Detection Measure the conjugation of endogenous small molecules to drug candidates after in vivo administration.
- CYP Induction Detect increases in the expression of various isoforms of cytochrome P450 (CYP450).
- CYP Inhibition Assay Assess the inactivation and inhibition of cytochrome P450 (CYP450) in microsomes isolated from primary human hepatocytes or liver.
- CYP Isozyme Mapping Determine the isozymes of cytochrome P450 (CYP450) involved in the metabolism of a drug candidate.
Show all 27 in In Vitro ADME
- Cytochrome P450s Assess the inhibition or induction of the various isozymes of cytochrome P450s by drug candidates.
- Drug Distribution Studies Determine the metabolic fate of compounds within tissues, organs and plasma.
- Drug Drug Interactions Determine whether a substance affects the activity of a drug when both are administered together.
- Isotopic Labeling Track labeled isotopes through a metabolic pathway or cell by measuring mass, vibrational mode or radioactive decay.
- Metabolic Stability Measure metabolic vulnerability to drug metabolizing enzymes using cell-free, cell-based and in vivo assays.
- Metabolic Stability in Hepatocytes Assess the susceptibility of drugs to metabolism by Phase I (CYP450) and Phase II enzymes in liver cells.
- Metabolic Stability in Microsomes Assess the susceptibility of drugs to metabolism by Phase I (CYP450) and Phase II enzymes in liver microsomes.
- Metabolite Generation Analyze the formation of drug metabolites after administration of drug to an animal model or patient.
- Metabolite Identification Identify drug metabolites that are formed after administration of drug to an animal model or patient.
- Metabolite Quantification Quantify drug metabolites formed after drug administration to an animal model or patient.
- Metabolite Structural Elucidation Use analytical tools to characterize metabolite structure.
- Metabolite Synthesis Synthesize drug metabolites that are formed after administration of drug to an animal model or patient.
- No Label Methods Use mass spectrometry to detect and identify non-radiolabeled drug intermediates in pre-clinical samples.
- Phase I Metabolism Use enzymes such as cytochrome P450 oxidases to introduce reactive or polar groups into xenobiotics.
- Phase II Metabolism Use transferase enzymes such as glutathione S-transferases to conjugate phase I xenobiotics to polar compounds.
- Plasma Stability Assay Determine degradation rate of drug candidates in plasma.
- Protein Binding Ultrafiltration Measure the rate at which unbound drug passes through a dialysis membrane that models epithelial barrier pore size.
- Radiolabeled Tracers Use radiolabeled drug metabolites as radiotracers for measuring desired physiological processes.
- Reactive Metabolite Ensure that your drug candidate is not generating toxic reactive metabolites in vivo.
- Red Blood Cell (RBC) Partitioning (Blood/Plasma Ratio) Measure the distribution of a compound between red blood cells and plasma.
- Reference Standards Find reference standards for assays, tests and services.
In Vitro Pharmacology
- In Vitro Eye Models Measure cytokine production, cell viability, apoptosis and wound healing.
In Vivo ADME
- Absorption studies Study the factors determning how efficiently a compound may enter the bloodstream.
- Quantitative Whole Body Autoradiography (QWBA) Determine the tissue distribution of a radiolabeled compound in Rodent and Non-Rodent Species.
In Vivo Pharmacokinetics
- In Vivo PK Consulting Expert advice on pharmacokinetics and how specific drugs affect the body to determine function, effectiveness, dosage size, etc…
- Mass Balance Elucidate excretory pathways and organ distribution of a parent drug and metabolites
- Pharmacokinetic (PK) Screening - Other Species Run pharmacokinetic studies in large animals that measure a drug's absorption, distribution, metabolism and excretion.
Protein Sciences
- Mass Spectrometry-Based Proteomics Detect histone post-translational modifications (hPTMs), histone variants, and interactomes at chromatin regions.
Testing Services
- Freeze-Thaw Testing Use freeze-thaw cycling to measure the long-term durability of cosumer products.
Where it operates
Sites by country, with the cities in each.
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United States 1 site
About this supplier
In the supplier's own words, as listed in the Scientist.com network.
Increased Value Pharmaceutical Outsourcing, LLC is a technical consulting business that provides drug metabolism, pharmacokinetics, and mechanism-based translational medicine expertise for small and large drug discovery and development organizations.
- Website
- iv-po.com
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