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Avastus Preclinical Services
Avastus Preclinical Services is listed as a mid sized business research supplier in the Scientist.com network, with 3 sites in 1 country.
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Services
What this research supplier says it provides, as listed in the Scientist.com network.
Type of company: Mid sized business
Bioimaging
- In Vivo Whole Tissue and Animal Imaging Visualize, analyze and track light producing reporters in whole animals.
- Luminescence Imaging Monitor biological processes and pathologies using reporter proteins such as firefly and Renilla luciferase.
- Microscopy Use microscopy to analyze surfaces of biological materials and to develop 3D images of biological structures.
Biomarkers
- In Vivo Apoptosis Detection Visualize and quantify apoptosis in real time.
- Lipid Profiling Use quantitative analysis of blood lipid components to assess cardiac risk.
Disease Models
- Arthritis Models Measure therapeutic endpoints in animal models of arthritis.
- Atopic Dermatitis Models Measure therapeutic endpoints in animal models of atopic dermatitis.
- Autoimmune Models Measure therapeutic endpoints in animal models with autoimmune disorders.
- Bacterial Infection Models Measure therapeutic endpoints in animal models of bacterial infection.
- Behavioral Testing Models Investigate sensory-motor and emotional functions, social behavior and day-night activity.
- Blood Models Test for therapeutic efficacy of drug candidates in blood disorder models.
Show all 27 in Disease Models
- General Pain Models Measure therapeutic endpoints in animal models of general pain.
- Hematopoiesis Models Measure therapeutic endpoints in animal models of hematopoiesis.
- In Vivo Physiologic Monitoring Monitor and collect data from conscious, freely moving laboratory animals.
- In Vivo Technologies Models Carry out EEGs, cognition assessment, microdialysis, electrophysiology, MRI, ultrasound and tomographic analysis.
- Infectious Disease Models Test therapeutic efficacy of drug candidate in infectious disease model.
- Inflammation Models Measure therapeutic endpoints in animal models for inflammation.
- Inflammatory Pain Models Measure therapeutic endpoints in animal models of inflammatory pain.
- Ischemia Models Measure therapeutic endpoints in animal models of ischemia.
- LPS Acute Response Models Measure therapeutic endpoints in acute models of inflammation.
- Microsurgery in Rodents Outsource microsurgeries projects required for testing new therapies on a rodent model.
- Neuroscience Models Test therapeutic efficacy of drug candidate in neurological disease model.
- Non Obese Diabetic Mice Use a single animal species to create one or more disease models for diabetes.
- Ob/ob Mouse Use a single animal species to create one or more disease models obesity and angiogenesis.
- Obese Mice Use a single animal species to create one or more disease models for diet-induced obesity and type II diabetes.
- Osteoarthritic Pain Models Measure therapeutic endpoints in animal models of osteoarthritic pain.
- Osteoarthritis Models Measure therapeutic endpoints in animal models of osteoarthritis.
- Pain Endpoints Models Measure therapeutic endpoints in animal models of pain.
- Pain Model Consulting Expert advice to better evaluate and understand pain thresholds and phenomena within living organisms. Can be used to evaluate pain associated with specific diseases or injuries affecting the sensory and nervous systems.
- Pain Models Test therapeutic efficacy of drug candidate in pain model.
- Respiratory Models Test therapeutic efficacy of drug candidate in respiratory disease model.
- Systemic Lupus Erythematosus Models Measure therapeutic endpoints in animal models of immune disorders such as SLE and lupus.
Effectiveness
- Antimicrobial Pharmacodynamics Ascertain the effectiveness of an antimicrobial compound and test levels of antibiotic resistance against specific bacterial pathogens.
- Bioequivalence Studies for Veterinary Drugs Assess the expected biological equivalence of two proprietary preparations of a veterinary drug.
- Laboratory Dose Confirmation Studies Conduct in vivo studies to confirm the effectiveness of a selected drug dose in the lab.
- Laboratory Dose Determination Studies Compare the effectiveness of three non-zero therapeutic concentrations for various durations to a non-medicated control group, and a non-medicated uninfected control group.
Show all 88 services
General in vivo Toxicology
- Dose Range Finding Study - Mouse Conduct a study to determine the dose range of your compound in mice.
- General Toxicology Use in vivo models to assess acute and sub-acute toxicity as well as chronic and sub-chronic toxicity.
- IV Toxicology Test the toxicological effect of IV delivery of drug candidate.
- Repeat Dose Toxicity Study - Rat Conduct a repeat dose study in rats to determine the toxicity and toxicokinetic behavior of your compound.
In Vitro Assays
- Cell Proliferation Measure cell number, cell viability and cell division.
- Microbiology Study microbes and their role in human health.
In Vitro Pharmacology
- Drug Target Assays Gain insight into the selectivity and mode-of-action of a compound's pharmacological targets.
- HuGEMM - Immuno-Oncology Model Evaluate human-specific therapeutics for checkpoint inhibitors, including anti-human PD-1, anti-human PDL-1, and anti-human CTLA-4 antibodies.
- Immuno-oncology Targets Develop drugs that take advantage of the immune system to target cancer cells.
- In Vitro Hypoxia Models Use in vitro models to measure therapeutic endpoints associated with hypoxia.
- In Vitro Oncology Models Use cell-based and biochemical models of cancer.
- Protein/Enzyme Targets For requesting Protein/Enzyme Targets
Show all 8 in In Vitro Pharmacology
- Target Identification Identify the target(s) of a biologically active substance.
- Target Validation Demonstrate that modification of target activity has potential therapeutic benefits.
In Vivo ADME
- Absorption studies Study the factors determning how efficiently a compound may enter the bloodstream.
- Tissue Distribution Study the tissues in which a compound or its metabolites, accumulate.
In Vivo Pharmacokinetics
- In Vivo Pharmacokinetics Run pharmacokinetic studies in animals that measure a drug's absorption, distribution, metabolism and excretion (ADME).
- In Vivo PK Consulting Expert advice on pharmacokinetics and how specific drugs affect the body to determine function, effectiveness, dosage size, etc…
- Pharmacokinetic (PK) Screening Measure the absorption, distribution, metabolism and excretion of a compound.
- Pharmacokinetic (PK) Screening - Mouse Run pharmacokinetic studies in mice that measure a drug's absorption, distribution, metabolism and excretion.
- Pharmacokinetic (PK) Screening - Rat Run pharmacokinetic studies in rats that measure a drug's absorption, distribution, metabolism and excretion.
- Rat Efficacy Combination Use rat models to determine the anti-cancer efficacy and potential synergy of a drug candidate with a standard drug treatment.
Show all 8 in In Vivo Pharmacokinetics
- Repetitive Maximum Tolerated Dose (MTD) Mouse Study Use mouse models to determine the MTD of a drug candidate by repetitive administrations for 7 days.
- Repetitive Maximum Tolerated Dose (MTD) Rat Study Use rat models to determine the MTD of a drug candidate by repetitive administrations for 7 days.
Model Development
- Animal Model Development Create new systems for profiling pre-clinical therapeutics, devices, and surgical techniques.
- Custom Model Development Develop a custom disease model.
- Disease Model Database For sourcing disease models.
- Knockout Mice Create transgenic mice that are genetically engineered to inactivate a gene or set of genes.
- Lewis Rat Use a single animal species to create one or more disease models for metastatic cancer, hematopoiesis and anemia.
- SCID Mouse Use a single animal species to create one or more disease models for spontaneous and metastatic cancer and cachexia.
Show all 11 in Model Development
- SCID/BG Mouse Use a single animal species to create one or more disease models for metastatic cancer.
- Sprague Dawley Rat Use a single animal species to create one or more disease models for cachexia.
- Standard Models Create new animal disease models or modify existing models to study specific diseases, side-effects or symptoms.
- Surgical Models Create new animal models using techniques such as vascular catherization, soft tissue procedures or device implants.
- Transgenic Models Create animal models engineered for use in a specific therapeutic area.
Oncology Models
- Athymic Mouse Use a single animal species to create one or more disease models for cachexia and spontaneous cancer.
- NCG Model Study tumor biology and immuno-oncology in the CRISPR/Cas9-generated immunodeficient mouse model.
- Oncology Xenografts Xenografts derived from oncological samples.
- Ovarian Cancer Mouse Measure therapeutic endpoints in animal models of ovarian cancer.
- Renal Xenograft Measure therapeutic endpoints in renal models of cancer.
Safety Pharmacology
- Neurotoxicity Study Study of the adverse effects of a substance on the brain or peripheral nervous system.
Specialty Dosing Routes
- Dermal Toxicology Assess toxicity in rodent dermal testing models.
- Repeat Dose Intranasal Study - Mouse Conduct a repeat dose intranasal study in mice to determine the toxicity and toxicokinetic behavior of your compound.
- Repeat Dose Intranasal Study - Rat Conduct a repeat dose intranasal study in rats to determine the toxicity and toxicokinetic behavior of your compound.
- Single Dose Acute Intranasal Study - Mouse Conduct a single dose intranasal study in mice to determine the toxicokinetic behavior of your compound.
- Single Dose Acute Intranasal Study - Rat Conduct a single dose intranasal study in rats to determine the toxicokinetic behavior of your compound.
- Single Dose Acute Intravenous Infusion Study - Other Species Conduct a single dose intravenous infusion study in other species to determine the toxicokinetic behavior of your compound.
Show all 7 in Specialty Dosing Routes
- Single Dose Acute Intravenous Infusion Study - Rats Conduct a single dose intravenous infusion study in rats to determine the toxicokinetic behavior of your compound.
Target Animal and Human Food Safety
- Tolerance Studies Conduct tolerance studies on target animals of veterinary products.
- Toxicity Test for Veterinary Drugs Use the drug at 10X the recommended dose for 3X the recommended duration to evaluate its safety.
- Toxicokinetic Analysis Determine the drug concentration at which off-target or toxic effects occur.
Other services
- New Request
Where it operates
Sites by country, with the cities in each.
-
United States 3 sites
About this supplier
In the supplier's own words, as listed in the Scientist.com network.
We provide a vast array of services to the research industry that are beneficial to companies of all sizes, from biotechnology start-ups,Virtual R&D groups, to the largest multinational firms. As with all great things, discovery drug development begins with an idea or a simple concept. These potential life altering ideas require funding, regulatory navigation, and a significant amount of infrastructure to go from concept to real world application. For new and growing pharmaceutical companies, this funding is increasingly hard to attain. We strive to extend your operating runway. DRUG...
Show the full description
We provide a vast array of services to the research industry that are beneficial to companies of all sizes, from biotechnology start-ups,Virtual R&D groups, to the largest multinational firms. As with all great things, discovery drug development begins with an idea or a simple concept. These potential life altering ideas require funding, regulatory navigation, and a significant amount of infrastructure to go from concept to real world application. For new and growing pharmaceutical companies, this funding is increasingly hard to attain. We strive to extend your operating runway.
DRUG RESEARCH SERVICES
Our research team functions as your partner to compound evaluation. The services we offer are instrumental to drug development and provide the client with insight into drug efficacy and tolerability. We offer in vitro assay development and cell-based assaysand an array of disease models including microbial infectious disease, diet-induced obesity, diabetes, patient derived xenografts, arthritis, LPS-induced cytokine production, rare genetic diseases, as well as surgical disease models. Our offerings also include breeding services for genetic disease models. Our staff is made up of the most adaptive, creative minds; if you can imagine it, we can put it into action.
ANIMAL WELFARE AND FACILITIES MANAGEMENT
We provide your business infrastructure; we offer affordable housing and husbandry services and the use of laboratory space to perform experiments. We also offer our clients use of our Institutional Animal Care and Use Committee (IACUC) for review of protocols and grant proposal review, as well as many other useful services. By facilitating these services, we allow brilliant minds to focus on the most important aspects of their research. The services we provide allow for the scientist to focus on results.
- Professional associations
- MassBio
- Website
- www.avastusps.com
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