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Quintara Discovery
Quintara Discovery is listed as a small business research supplier in the Scientist.com network, with 1 site in 1 country and 1 service area.
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Services
What this research supplier says it provides, as listed in the Scientist.com network.
Type of company: Small business
Antibodies
- Antibody Sequencing Sequence cDNA encoding variable heavy (VH) and variable light (VL) domains of a hybridoma cell line.
- Hybridoma Sequencing/Antibody Sequencing Determine the sequences of monoclonal antibodies.
Biomarkers
- Immunoassays Create antibody-based assays for the identification and quantification of specific antigens.
Chemical and Compound Analysis
- Chemical Stability Measure the stability of small molecules in solution.
- Non GLP Large Molecule Bioanalysis Detect and analyze the pharmacokinetic profile of large biomolecules.
- Non GLP Small Molecule Bioanalysis Detect and analyze the pharmacokinetic profile of small molecules.
- Partition Coefficient Determine lipophilicity (hydrophobicity) of compounds by measuring log P.
- Solubility Studies Analyze substances for kinetics of solubility using nephelometry and UV-Vis spectrometry.
DNA & RNA
- DNA Extraction Extract DNA from an original source.
- DNA Mutagenesis Introduce insertions, deletions and substitutions into DNA clones.
- Genomic DNA cloning Clone and propagate genomic DNA inserts of 5-50kb.
- Oligo Synthesis Produce oligonucleotides for microarrays, RT-PCR and PCR cloning.
- Plasmid DNA Preparation and Extraction Prepare plasmid DNA starting from E. coli cell pellets, transformed colonies or DNA samples.
- Restriction Fragment Length Polymorphism Identification Uses gel electrophoresis to identify differences in restriction fragment lengths produced by enzymatic digestion of DNA.
Show all 33 services
In Vitro ADME
- Blood Brain Barrier Measure movement of drugs from circulating blood to brain extracellular fluid.
- CYP Induction Detect increases in the expression of various isoforms of cytochrome P450 (CYP450).
- CYP Inhibition Assay Assess the inactivation and inhibition of cytochrome P450 (CYP450) in microsomes isolated from primary human hepatocytes or liver.
- CYP Isozyme Mapping Determine the isozymes of cytochrome P450 (CYP450) involved in the metabolism of a drug candidate.
- Cytochrome P450s Assess the inhibition or induction of the various isozymes of cytochrome P450s by drug candidates.
- GI Fluid Stability Determine dosing and turnover of drug candidates in gastrointestinal fluids.
Show all 17 in In Vitro ADME
- Intestinal Permeability Use Caco 2 and MCDK cells to assess mono-directional drug transport by passive diffusion in culture.
- Membrane Transporters Use Caco 2 cells to assess bi-directional drug transport in the presence or absence of P-glycoprotein (P-gp) inhibitors.
- Metabolic Stability Measure metabolic vulnerability to drug metabolizing enzymes using cell-free, cell-based and in vivo assays.
- Metabolic Stability in Hepatocytes Assess the susceptibility of drugs to metabolism by Phase I (CYP450) and Phase II enzymes in liver cells.
- Metabolic Stability in Microsomes Assess the susceptibility of drugs to metabolism by Phase I (CYP450) and Phase II enzymes in liver microsomes.
- Metabolite Quantification Quantify drug metabolites formed after drug administration to an animal model or patient.
- Metabolite Structural Elucidation Use analytical tools to characterize metabolite structure.
- Multidrug Resistance Identify potential causes of drug-drug interactions.
- Plasma Stability Assay Determine degradation rate of drug candidates in plasma.
- Protein Binding Ultrafiltration Measure the rate at which unbound drug passes through a dialysis membrane that models epithelial barrier pore size.
- Reactive Metabolite Ensure that your drug candidate is not generating toxic reactive metabolites in vivo.
Protein Sciences
- Yeast Two Hybrid Search novel interactions or confirm hypothesized protein-protein interactions using pairwise assays.
REACH Services
- OECD 471: Bacterial Reverse Mutation Test (Ames) Measure the mutagenic potential of test compounds.
Service areas:
Where it operates
Sites by country, with the cities in each.
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United States 1 site
About this supplier
In the supplier's own words, as listed in the Scientist.com network.
Quintara Discovery offers a full spectrum of in vitro ADME assays for small molecule drug discovery and preclinical development that are performed exclusively in South San Francisco. Quintara has an experienced scientific team available for real-time communication, discussion and consultation. The strong focus on lab operation, automation, instrumentation and project management enables an industry-leading turn-around delivery time with excellent quality. With a customer-centric philosophy, Quintara strives to be your partner in drug R&D.
- Website
- qdibio.com
Work with Quintara Discovery on Scientist.com
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