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Carna Biosciences, Inc.
Carna Biosciences, Inc. is listed as a small business research supplier in the Scientist.com network, with 1 site in 1 country and 1 service area.
View Carna Biosciences, Inc. on Scientist.com
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Sites
1
Countries
1
Services
What this research supplier says it provides, as listed in the Scientist.com network.
Type of company: Small business
Biomarkers
- Lipid Kinase Assays Use biochemical, cell-based or in vivo assays to measure lipid kinase activity.
- T Cell Epitope Characterization Evaluate the potency and immunodominance of T-cell epitopes within a molecule.
Cell Culture and Characterization
- Cell Line Construction Create new recombinant cell lines to exact specifications.
- Recombinant Technology Manipulate genotypes to introduce or modify the expression of specific cell products or physical traits.
Chemical and Compound Analysis
- Protein Crystallization Create high quality protein-ligand crystals for x-ray diffraction studies.
- Protein Structure Determine the three dimensional structure of a protein by NMR or x-ray crystallography.
- Structure Determination Determine the three-dimensional structure of proteins in the presence or absence of ligands.
Data Science/Bioinformatics
- Discovery Compound Screening Analytics Screening of an entire compound library directly against the drug target or in a more complex assay.
In Vitro Assays
- Apoptosis Assays Detect apoptotic events that lead to programmed cell death.
- Assay Development Construct or create new assays or modify existing ones.
- Cell Based Assays Apply compounds to cells and test for cellular phenotypes and effects on gene expression
- Cell Proliferation Measure cell number, cell viability and cell division.
- HTS Assay Development Develop assays to use in high throughput screening.
- Luciferase Reporter Assay Evaluate promoter activity by measuring light output from the luciferase enzyme.
Show all 8 in In Vitro Assays
- Pathway Mapping Define mechanisms of action by analyzing protein pathways affected by drug treatment.
- Phenotype Assays Measure effects of drug candidate on the morphology or function of cells and whole animals.
Show all 61 services
In Vitro Pharmacology
- Anaplastic lymphoma kinase (ALK) Assays Use biochemical, cell based or in vivo assays to measure ALK enzyme activity.
- ATP Competitive Study Determine whether or not a compound is competitive with ATP.
- Drug Target Assays Gain insight into the selectivity and mode-of-action of a compound's pharmacological targets.
- Extracellular signal Regulated Kinase Assays Use biochemical, cell based or in vivo assays to measure ERK enzyme activity.
- Fibroblast Growth Factor Receptor (FGFR) Assays Use biochemical, cell based or in vivo assays to measure FGF receptor activity.
- G-Protein Coupled Receptor (GPCR) Assays Detect ligand binding, receptor dimerization and downstream signal transduction events.
Show all 28 in In Vitro Pharmacology
- High Throughput Screening Conduct millions of chemical, genetic or pharmacological tests in a short period of time.
- Human Epidermal growth factor Receptor (HER) Assays Use biochemical, cell based or in vivo assays to measure HER receptor activity.
- Immuno-oncology Assays Use biochemical, cell based or in vivo assays to measure the activity of immuno-therapy targets.
- Immuno-oncology Targets Develop drugs that take advantage of the immune system to target cancer cells.
- In Vitro Enzyme Activity Assay Development Develop new in vitro enzyme activity assays or modify existing ones.
- Kinase Assays Measure activity of over 500 kinases in biochemical or cell-based assays.
- Mitogen/Extracellular signal-regulated Kinase (MEK) Assays Use biochemical, cell based or in vivo assays to measure MEK enzyme activity.
- Mutant B-Raf Assays Use biochemical, cell based or in vivo assays to measure mutant B-Raf enzyme activity.
- Phosphatidylinositol 3-Kinase (PI3K) Assays Use biochemical, cell based or in vivo assays to measure PI3K enzyme activity.
- Protein Kinase B (Akt) Assays Use biochemical, cell based or in vivo assays to measure Akt enzyme activity.
- Protein Targets Protein Targets are of pharmaceutical interest for drug discovery purposes.
- Protein/Enzyme Targets For requesting Protein/Enzyme Targets
- Raf Assays Use biochemical, cell based or in vivo assays to measure Raf enzyme activity.
- Reversibility Study Determine whether or not a compound inhibits an enzyme reversibly.
- Selectivity Profiling Determine the specificity of a ligand for its target by testing it against a large panel of related target proteins.
- Substrate Competitive Study Determine whether or not a compound is competitive with a substrate.
- Target Characterization Characterize potential drug targets during the drug discovery process.
- Target Identification Identify the target(s) of a biologically active substance.
- Target Validation Demonstrate that modification of target activity has potential therapeutic benefits.
- Time Dependent Study Determine whether or not a compound binds to an enzyme in a time-dependent manner.
- Vascular Endothelial Growth Factor (VEGF) Assays Use biochemical, cell based or in vivo assays to monitor competitive or non-competitive binding of VEGF ligand.
- Vascular Endothelial Growth Factor Receptor (VEGFR) Assays Use biochemical, cell based or in vivo assays to measure VEGF receptor activity.
Protein Sciences
- ELISA Detect the presence of antigens recognized by antibodies or find antibodies that recognize an antigen.
- Fusion Proteins Use recombinant DNA technology to create and express proteins derived from more than one gene.
- Insect Expression Use baculovirus infected cells or non-lytic cell systems to produce glycosylated proteins.
- Large Scale Protein Production Produce large amounts of protein using fermentors, wave mixers, bioreactors, and large-scale purification workflows.
- NanoBRET™ Technology Measure real-time protein interactions in living cells.
- Peptide/Protein Products Purchase off-the-shelf protein or peptide products.
Show all 15 in Protein Sciences
- Phosphorylation Analysis Identify phosphorylation sites in target proteins.
- Protein Binding Determine drug-protein binding interactions
- Protein Conjugation Create tagged monoclonals, polyclonal and recombinant proteins.
- Protein Expression Produce recombinant proteins in prokaryotic or eukaryotic systems.
- Protein Interaction Measure the interaction of a protein to other macromolecules or peptide ligands.
- Protein Products Find native and recombinant proteins and peptides.
- Protein Services Consulting Expert advice to evaluate and analyze protein function and expression.
- Recombinant Proteins Use recombinant DNA to produce proteins in vivo or in vitro.
- X-Ray Crystallography Elucidate structures of biological macromolecules such as proteins and nucleic acids.
Safety Pharmacology
- Off Target Effects Assess toxicities by body weight, clinical chemistry, hematology, urinalysis and terminal necropsy and pathology.
Other services
- New Request
Service areas:
Biology
Where it operates
Sites by country, with the cities in each.
-
United States 1 site
About this supplier
In the supplier's own words, as listed in the Scientist.com network.
Carna Biosciences offers kinase profiling, assay development, crystallography, and microarray services.
Drug discovery expertise:
- Kinase Protein
- Profiling Services
- Assay Development
- Crystallography
- Cell Based Assay Services
- Microarray (protein arrays such as reverse phase protein microarray (RPMA))
- Professional associations
- MassBio
- Website
- www.carnabio.com/english/product
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