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Cell Signaling Technology
Cell Signaling Technology is listed as a small business research supplier in the Scientist.com network, with 2 sites in 2 countries and 1 service area.
View Cell Signaling Technology on Scientist.com
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Search companies, drugs, suppliers and investigators, and follow each one to the others. Individual plan, $249/seat/mo. Card required.
Sites
2
Countries
2
Logo Unknown author Unknown author, via Wikimedia Commons, Public domain. Shown to identify the organization; it may be a registered trademark.
Services
What this research supplier says it provides, as listed in the Scientist.com network.
Type of company: Small business
Antibodies
- Antibody Conjugation Conjugate an enzyme, biotin, or fluorophore to an antibody.
- Antibody Detection Quantitate, localize and visualize proteins and other antigens.
- Antibody Products Purchase antibody, antibody pair kit or ELISA kit.
- Biotin-Antibody Conjugation Biotinylate an antibody for improved detection.
- Custom Antibodies Design and produce polyclonal and monoclonal antibodies.
- Direct Antibody Labeling Conjugate a primary antibody to a label for direct antigen detection.
Show all 13 in Antibodies
- Epitope Mapping Map the antibody-antigen binding region to define protein-protein interaction sites.
- Hybridoma Sequencing/Antibody Sequencing Determine the sequences of monoclonal antibodies.
- In Vitro Monoclonal Antibody Production Generate monoclonal antibodies in vitro using cultured antibody-secreting hybridoma cell lines.
- Phosphospecific Antibodies Create antibodies to detect phosphorylated protein targets.
- Polyclonal Antibody Production Generate polyclonal antibodies in vivo using evolutionary distant animal species.
- Polyclonal/Monoclonal Antibody Production Generate polyclonal or monoclonal antibodies in a range of animal species, over-express antibodies in cultured cells.
- Rabbit Monoclonal Antibody Development Develop monoclonal antibodies using rabbit as the host animal.
Biomarkers
- Biomarker Services Evaluating normal/abnormal biological conditions and characteristics within the body
- Cell Viability Measure changes in cell number, cell division, DNA content or a cell metabolism marker such as ATP levels.
- Diagnostic Biomarkers Discovery Identify candidate biomarkers indicative of the presence of a disorder.
- Epigenetics Epigenetics sits at the cutting edge of drug discovery. The ability to modify genomes without changing any sequences with methylation.
- Flow Cytometry Identify fluorescently-labeled cells or physically separate cells from a larger population using biomarkers.
- Immunoassays Create antibody-based assays for the identification and quantification of specific antigens.
Show all 10 in Biomarkers
- Immunohistochemistry Examine the toxic effects of pre-clinical compounds in small animal and patient histological samples.
- Immunophenotyping Separate cell types based on their expression of biomarkers or based on their individual and unique expression patterns.
- Predictive Biomarkers Discovery Identify candidate biomarkers suggestive of a response to a treatment.
- Propidium Iodide FACS Analysis Use DNA staining and flow cytometry to analyze the cell cycle and detect apoptosis or cell proliferation.
Show all 75 services
Cell Culture and Characterization
- Chromosomal Characterization Establish karyotype/chromosome profile by cytogenetic analysis of cell preparation.
Clinical Consulting
- Biomarker Services Consulting Expert advice to conduct solutions for evaluating normal/abnormal biological conditions and characteristics within the body.
Discovery Chemistry
- LCMS Analysis Physically separate substances using liquid chromatography and mass spectrometry.
DNA & RNA
- ChIP-sequencing Profiling Identify where a protein is binding to DNA on a genome-wide scale.
- Methylation Analysis Determine genomic methylation patterns and analyze methylation in tumors and treated samples.
In Vitro ADME
- Cell Fractionation Isolate organelles and subcellular components.
In Vitro Assays
- Annexin V Apoptosis Assay Detect and quantify apoptotic cells based on loss of membrane asymmetry.
- Apoptosis Assays Detect apoptotic events that lead to programmed cell death.
- Apoptotic Cell Staining Detect apoptotic cells in culture.
- Caspase Assay Detect early to mid stage apoptosis or differentiate apoptosis from necrosis.
- Cell Based Assays Apply compounds to cells and test for cellular phenotypes and effects on gene expression
- Cell Based Assays Consulting Expert advice to evaluate the functions of specific chemicals based on their constructions and systems.
Show all 11 in In Vitro Assays
- Cell Proliferation Measure cell number, cell viability and cell division.
- High Content Screening Analyze whole cells or components of cells with simultaneous readout of several parameters.
- Inflammation Assays Identify and validate pro- and anti-inflammatory molecules, recruitment inhibitors and chemotaxis modulators.
- Pathway Mapping Define mechanisms of action by analyzing protein pathways affected by drug treatment.
- Stem Cell Differentiation Microscopy Assay› Elucidate mechanisms of stem cell renewal and differentiation in vitro using fluorescence microscopy.
In Vitro Pharmacology
- Anaplastic lymphoma kinase (ALK) Assays Use biochemical, cell based or in vivo assays to measure ALK enzyme activity.
- B-Cell Lymphoma 2 (BCL-2) Assays Use biochemical, cell based or in vivo assays to measure BCL-2 protein activity.
- Cytotoxic T-Lymphocyte Antigen-4 (CTLA-4) Assays Use biochemical, cell based or in vivo assays to measure CTLA-4 receptor activity.
- Extracellular signal Regulated Kinase Assays Use biochemical, cell based or in vivo assays to measure ERK enzyme activity.
- Human Epidermal growth factor Receptor (HER) Assays Use biochemical, cell based or in vivo assays to measure HER receptor activity.
- Immuno-oncology Assays Use biochemical, cell based or in vivo assays to measure the activity of immuno-therapy targets.
Show all 14 in In Vitro Pharmacology
- Immuno-oncology Targets Develop drugs that take advantage of the immune system to target cancer cells.
- Mammalian Target of Rapamycin Complex Assays Use biochemical, cell based or in vivo assays to measure mTORC enzyme activity.
- Phosphatidylinositol 3-Kinase (PI3K) Assays Use biochemical, cell based or in vivo assays to measure PI3K enzyme activity.
- Programmed Cell Death-1 (PD-1) Assays Use biochemical, cell based or in vivo assays to measure PD-1 receptor activity.
- Programmed Death-Ligand 2 (PD-L2) Assays Use biochemical, cell based or in vivo assays to monitor competitive or non-competitive binding of PD-L2 ligand.
- Protein Kinase B (Akt) Assays Use biochemical, cell based or in vivo assays to measure Akt enzyme activity.
- Target Identification Identify the target(s) of a biologically active substance.
- Vascular Endothelial Growth Factor (VEGF) Assays Use biochemical, cell based or in vivo assays to monitor competitive or non-competitive binding of VEGF ligand.
In Vitro Toxicology
- Cytotoxicity Test for effects on cell viability and proliferation
Protein Sciences
- ELISA Detect the presence of antigens recognized by antibodies or find antibodies that recognize an antigen.
- Fluorophore Protein Conjugation Attach a fluorescent probe to a protein.
- Immunoprecipitation Precipitate a protein of interest out of solution using an antibody to which it binds.
- Mass Spectrometry-Based Proteomics Detect histone post-translational modifications (hPTMs), histone variants, and interactomes at chromatin regions.
- Peptide Synthesis Synthesize custom peptides that are long, have unusual modifications or are cyclic.
- Peptide/Protein Products Purchase off-the-shelf protein or peptide products.
Show all 19 in Protein Sciences
- Phosphorylation Analysis Identify phosphorylation sites in target proteins.
- Protein Conjugation Create tagged monoclonals, polyclonal and recombinant proteins.
- Protein Identification Uncover or confirm the identity of a protein.
- Protein Post-translational Modification Analysis Measure glycosylation, phosphorylation, sulfation, ubiquitination, methylation and acetylation.
- Protein Production Produce recombinant protein molecules in prokaryotic or eukaryotic systems.
- Protein Products Find native and recombinant proteins and peptides.
- Protein Services Consulting Expert advice to evaluate and analyze protein function and expression.
- Proteomics Do large-scale experimental analysis of proteins focused on understanding structure and function.
- Qualitative MS Perform direct identification of molecules based on mass-to-charge ratio and fragmentation patterns.
- Quantitative MS Quantify small and large molecules in the pg/ml range
- Recombinant Proteins Use recombinant DNA to produce proteins in vivo or in vitro.
- SILAC Enable incorporation of isotopic labels in proteins for mass spectrometry-based quantitative proteomics.
- Western Blots Detect specific proteins in a sample of tissue homogenate or extract.
Other services
- New Request
Service areas:
Biology
Where it operates
Sites by country, with the cities in each.
-
Netherlands 1 site
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United States 1 site
About this supplier
In the supplier's own words, as listed in the Scientist.com network.
Cell Signaling provides target validation services, biomarker discocvery services, phospho-specific antibody design services and patient stratification services.
- Website
- www.cellsignal.com
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