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ScitoVation

ScitoVation is listed as a small business research supplier in the Scientist.com network, with 2 sites in 1 country.

Search companies, drugs, suppliers and investigators, and follow each one to the others. Individual plan, $249/seat/mo. Card required.

Sites 2

Countries 1

Type of company: Small business

Agricultural Sciences Research & Development

Agrochemical Identification Product identification and composition of pesticides; which includes fungicides, insecticide, herbicides and nematicides analysis.
Animal Feed Supplements Test for mineral nutrients and medicinal compounds for the prevention or control of disease.
Chemical and Physical Determination of chemical and physical properties of pesticide product.
General Agrochemical Compound Library Find potential compound candidates for agrochemical or agro-product research and development.
Method Development & Validation Engineer sensitive and selective methods that meet GLP validation requirements to access different agrochemical properties
Molecular Markers Use of molecular diagnostics to analyze biological markers in the genome and proteome.

Show all 7 in Agricultural Sciences Research & Development 1 more

Synthetic Fertilizers Determination of heavy metals and other toxic compounds in addition to composition.

Bioimaging

Confocal/Optical Microscopy Use optical imaging technique to increase optical resolution and contrast of a micrograph.
Cryo Electron Microscopy Examine the 3D structure of biological complexes and organelles.
Electron Microscopy Examine the fine structures of molecules, cells and tissues with sub-nanometer resolution.
Microscopy Use microscopy to analyze surfaces of biological materials and to develop 3D images of biological structures.
Single Molecule Localization Microscopy Enable structural resolution of biological samples at the nanometer range using light in the visible spectrum.

Biomarkers

Cell Viability Measure changes in cell number, cell division, DNA content or a cell metabolism marker such as ATP levels.
In Vivo Apoptosis Detection Visualize and quantify apoptosis in real time.
Multi-Omics Study Use an integrated multi-omics study to understand a disease mechanism.
Propidium Iodide FACS Analysis Use DNA staining and flow cytometry to analyze the cell cycle and detect apoptosis or cell proliferation.
Single Cell Isolation Isolate single cells for subsequent single-cell analysis.
Single Cell quantitative Real Time-PCR Assess gene expression levels and patterns in a single cell.

Show all 9 in Biomarkers 3 more

Single Cell Transcriptome Sequencing Detect distinct, rare or abnomal cell types in a heterogenous population.
TUNEL Assay Detect in situ DNA fragmentation.
Whole Transcriptome Amplification Amplify total RNA from a single cell.

Show all 124 services 107 more

Cell Culture and Characterization

3D Cell Culture Use a scaffold-based or scaffold-free format to grow three dimensional cell and tissue structures.
Cell Line Construction Create new recombinant cell lines to exact specifications.
Recombinant Technology Manipulate genotypes to introduce or modify the expression of specific cell products or physical traits.
Spectral Karyotyping Identify chromosomal abnormalties often not detected by traditional methods.

Chemical and Compound Analysis

Chemical Stability Measure the stability of small molecules in solution.
Denaturing High Performance Liquid Chromatography Separate mixtures of denatured and reannealed oligos to identify single nucleotide substitutions, deletions and insertions.
Dynamic Mechanical Analysis Measure mechanical properties of solids and polymer melts as a function of time, temperature and frequency.
Field Desorption Mass Spectrometry Use high potential fields to detect intact molecular ions of an analyte.
Fluorescence Mediated Tomography Visualize the spatial distribution of fluorescencently labeled probes and substances.
Light Sheet Fluorescence Microscopy Use a planar sheet of light to section transparent tissues and generate a 3D image.

Show all 14 in Chemical and Compound Analysis 8 more

Optical Tomographic Imaging Use multiply-scattered light to reconstruct images of illuminated objects.
Particle Size Analysis Measure particle size distribution and characterize particle size, porosity and composition.
Partition Coefficient Determine lipophilicity (hydrophobicity) of compounds by measuring log P.
Photostability Measure drug degradation rates after exposure to various light sources.
Phototoxicity & Photosensitization Test Test the potential for a product to elicit a reaction under UV exposure.
Solubility Studies Analyze substances for kinetics of solubility using nephelometry and UV-Vis spectrometry.
Total Internal Reflection Fluorescence Microscopy Visualize single molecule fluorescence at a surface to produce high quality images with low background.
X-ray Microscopy and Nanotomography (Nano-CT) Create two- and three-dimensional imaging of objects in real time.

Data Science/Bioinformatics

Discovery Statistical and Mathematical Modeling Use mathematical variables and equations to establish relationships between data.
In Silico ADME-PK Consultation Consult with experts for ADME-PK data analysis or predictive modelling design in different in vivo or in vitro states.
In Silico ADME-PK Predictions Use computer software to simulate in vivo physiological conditions of animals or humans to predict ADME-PK properties.
In Silico Cancer Genomics/Cancer Transcriptomics Analysis Interpret DNA sequencing and microarray data for cancer studies.
In Silico Drug-Drug Interactions Use computational tools to predict pharmaceutical, pharmacodynamic or pharmacokinetic drug-drug interactions to maximize drug regimen safety.
In Silico Epigenetic Compound Library Screening Use computer-aided methods to discover new compounds against key regulators of epigenetic signaling.

Show all 10 in Data Science/Bioinformatics 4 more

In Silico Nucleic Acid Microarray Analysis Use software to visualize and evaluate gene activity in response to various stimuli.
In Silico Pro-drug Predictions Use computer simulation to assess pro-drug absorption and conversion to predict pharmacokinetic properties.
In Silico Protein Microarray Analysis Use software to visualize and evaluate protein function and expression on a large scale.
In Silico Protein Modification Analysis Use computational methods to predict the behavior of modified proteins.

Discovery Chemistry

Compound Docking Identify potential compound hits based on the 3D structure of a target protein.
Discovery Computational Chemistry Model the interaction of a drug candidate with protein targets such as kinases, GPCRs, receptors, ion channels or enzymes.
In Silico Lead Optimization Use in silico design to enhance the ADME-PK properties of candidate drugs to maximize efficacy and safety.
In Silico Metabolite Predictions Conduct in silico assessment of metabolite pharmacokinetic properties and potential exposure effects.
Library Design & Evaluation Use structural knowledge to design target-focused compound libraries for screening.
Pharmacophore Modeling Use computer models to identify hits based on structural similarity to known active compounds.

Show all 8 in Discovery Chemistry 2 more

QSAR Analysis Develop quantitative structure–activity relationship models for drug design.
Virtual Screening Use software algorithms to virtually screen millions of potential compounds and peptides for binding.

Disease Models

Acute Lung Injury Models Measure therapeutic endpoints in animal models of acute lung injury.
Disease Simulation Modeling Disease Simulation Modeling
Precision Cut Lung Slices (PCLS) Use a phenotypically accurate model of lung behavior for screening and target validation.

DNA & RNA

Amplified Fragment Length Polymorphism Detection Detect DNA polymorphisms based upon restriction enzyme digestion and PCR.
Digital Polymerase Chain Reaction Obtain improved absolute target quantification and rare allele detection compared to conventional qPCR.
DNA Hydroxy Methylation Seq Use epigenetic services to analyze genome-wide DNA hydroxymethylation.
Genotyping Examine a DNA sequence to identify specific genetic varients .
Multiplex Cellular miRNA Assay Use Firefly™ technology for multiplex cellular microRNA profiling.
Quantitative RT PCR Use quantitative reverse transcription polymerase chain reaction to measure absolute and relative mRNA abundance.

Show all 9 in DNA & RNA 3 more

Restriction Fragment Length Polymorphism Identification Uses gel electrophoresis to identify differences in restriction fragment lengths produced by enzymatic digestion of DNA.
RNA Extraction Isolate total RNA or mRNA from cells or tissues
Single Cell RNA Sequencing Quantify mRNA variants in a single cell.

Drug Development

Safety Pharmacology Consulting Consulting services that help with the detection of potential undesirable pharmacodynamic effects of chemical entities on physiological functions.

Effectiveness

In Vitro Dose Determination Tests Determine the most appropriate effective drug dosage regimen(s) in vitro.

Environmental Assessment

Veterinary Environmental Assessment Assess whether environmental impacts may occur from the manufacture, use, or disposal of veterinary drugs.

General in vivo Toxicology

General Toxicology Use in vivo models to assess acute and sub-acute toxicity as well as chronic and sub-chronic toxicity.

In Vitro ADME

Cell Fractionation Isolate organelles and subcellular components.
Metabolic Stability in Hepatocytes Assess the susceptibility of drugs to metabolism by Phase I (CYP450) and Phase II enzymes in liver cells.
Plasma Stability Assay Determine degradation rate of drug candidates in plasma.

In Vitro Assays

3D Cell Microscopy Assay Investigate cellular and subcellular events in three dimensional 3D cultures by using fluorescence microscopy.
Annexin V Apoptosis Assay Detect and quantify apoptotic cells based on loss of membrane asymmetry.
Apoptosis Assays Detect apoptotic events that lead to programmed cell death.
Apoptotic Cell Staining Detect apoptotic cells in culture.
Assay Development Construct or create new assays or modify existing ones.
Caspase Assay Detect early to mid stage apoptosis or differentiate apoptosis from necrosis.

Show all 17 in In Vitro Assays 11 more

Cell Based Assays Apply compounds to cells and test for cellular phenotypes and effects on gene expression
Cell Based Assays Consulting Expert advice to evaluate the functions of specific chemicals based on their constructions and systems.
Cell Proliferation Measure cell number, cell viability and cell division.
Cytometric Bead Array (CBA) FACS Analysis Use flow cytometry and antibody-coated beads to simultaneously detect multiple target proteins.
High Content Screening Analyze whole cells or components of cells with simultaneous readout of several parameters.
HTS Assay Development Develop assays to use in high throughput screening.
In Vitro Assay Development Develop innovative assay and screening methods outside a living organism to enable a wide range of pre-clinical activities.
In Vitro Efficacy Test Use in vitro models to test the efficacy of your products.
In Vitro Human Cell Assays Request in vitro human cells for assays
Luciferase Reporter Assay Evaluate promoter activity by measuring light output from the luciferase enzyme.
Serine Protease Assay Detect apoptosis by measuring protease activity.

In Vitro Pharmacology

In Vitro Cardiovascular Models Measure stimulation and inhibition of lipolysis, adipogenesis and endothelial cell migration.
In Vitro Diabetes Models Measure insulin stimulation of glucose uptake and metabolism of lipids including cholesterol and triglycerides.
In Vitro Disease Models Screen pre-clinical candidates without the use of live animals.
In Vitro Hepatotoxicity Assays Use in vitro assays to measure hepatoxicity-related activities.
In Vitro Neural Models Use cultured neurons, neuronal progenitor cells and stem cell differentiation to create cellular models of neurological disease.

In Vitro Toxicology

Cytotoxicity Test for effects on cell viability and proliferation
Epidermal Cell Toxicity Measure toxicity by quantifying the number of live/dead cells, cell membrane integrity and glutathione (GSH) levels.
Hematopoietic Cell Toxicity Examine cytotoxic effects of pre-clinical compounds or biologics on adult stem cells.
Hepatocyte Toxicity Assess the cytotoxic effects of pre-clinical compounds on hepatocytes purified from patients and animal models.

Model Development

In Silico PK-PD Modeling Quantitative modeling and simulations correlation of pharmacokinetic and pharmacodynamic endpoints in support of preclinical and clinical development.

Protein Sciences

PEG Protein Conjugation Improve the therapeutic or pharmacokinetic properties of a protein by pegylation.

REACH Services

OECD 417: Toxicokinetics Study Obtain data on absorption, distribution, metabolism, and elimination of test substances.
OECD 473: In Vitro Mammalian Chromosomal Aberration Test Assess the ability of the test substance to cause structural chromosomal aberrations in cultured mammalian cells.
OECD 487: In Vitro Mammalian Cell Micronucleus Test Assess whether a test substance induces chromosomal changes in cultured cells.

Safety Pharmacology

Endocrine Disruptor Screening Use biochemical, cell based or in vivo assays to identify and quantify endocrine-modulating agents.
Safety Pharmacology Assess the impact of a therapeutic for human use on vital organ systems before first-in-man drug testing.

Scientific Data Services

Bioinformatics Bioinformatics is a powerful method of storing, retrieving and analyzing biological data.
Epigenomics Data Analysis Quantify and analyze DNA methylation and/or DNA binding protein data sets.
In Silico Genomics/Transcriptomics Data Analysis Interpret DNA sequencing and microarray data.
In Silico Metagenomics/Metatranscriptomics Data Analysis Use software to analyze genomic information from multiple environmental sources.
Metagenomics Data Analysis Deconvolute the genetic content of genomes contained in environmental samples by utilizing whole genome sequencing techniques to provide insight into microbial communities and host phenotypes.
Omics Informatics Consulting Services for the analysis of large-scale molecular data sets.

Show all 8 in Scientific Data Services 2 more

Pharmaco-genomics Genetic polymorphism contribution to inter-individual variability in drugs' responses and/or adverse events.
Small RNA Gene Expression Quantify and analyze miRNA, piRNA, siRNA as well as other small nuclear RNAs from small-RNA-seq raw input data sets.

Specialty Dosing Routes

Inhalation Toxicology Measure toxicity by daily clinical observation, body weight, clinical chemistry, hematology, and terminal necropsy and pathology.

Target Animal and Human Food Safety

Toxicokinetic Analysis Determine the drug concentration at which off-target or toxic effects occur.

Testing Services

Elevated Temperature Stability Determine the stability of a product at elevated temperature.
In Vitro Skin Models Measure skin model penetration and invasion, photosensitivity and toxicity.

Other services

Human Small Airway-On-a-Chip Study human lung inflammation and drug responses in vitro.
In Vitro Neurodegenerative Disease Platform Use an IVND platform to screen different compounds/drugs in a finely controlled synaptopathies scenario.
New Request

United States Durham, Morrisville 2 sites

Professional associations: AAPS, NCBIO, SOT, Society of Biomolecular Imaging and Informatics (SBI2)
Website: www.scitovation.com

Minority-owned

US small-business federal-contractor designation, self-certified in the U.S. federal System for Award Management (SAM.gov). Coverage is limited to matched U.S. small-business suppliers, so an absent designation is not evidence of its absence.

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