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PhenoVista Biosciences
PhenoVista Biosciences is listed as a small business research supplier in the Scientist.com network, with 1 site in 1 country.
View PhenoVista Biosciences on Scientist.com
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1
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Services
What this research supplier says it provides, as listed in the Scientist.com network.
Type of company: Small business
Bioimaging
- Bioimaging Visualize biological process non-invasively in real time.
- Confocal/Optical Microscopy Use optical imaging technique to increase optical resolution and contrast of a micrograph.
- Microscopy Use microscopy to analyze surfaces of biological materials and to develop 3D images of biological structures.
- Positron Emission Tomography (PET) Imaging Use PET imaging with radioactive agent to visualize and measure metabolic processes in the body.
Biomarkers
- Adipogenesis Assay Detect and quantify intracellular triglyceride accumulation in adipocytes.
- Cell Migration Assays Measure chemotaxis, haptotaxis, transmigration and wound-healing.
- Cell Viability Measure changes in cell number, cell division, DNA content or a cell metabolism marker such as ATP levels.
- Immunohistochemistry Examine the toxic effects of pre-clinical compounds in small animal and patient histological samples.
- Wound Healing Assay Use cell-based assays to investigate cell proliferation, cell migration and wound closure.
Cell Culture and Characterization
- 3D Cell Culture Use a scaffold-based or scaffold-free format to grow three dimensional cell and tissue structures.
- Adherent Cell Culture Grow monolayers of anchorage-dependent cells.
- Cell Culture Culture primary or immortalized cell lines.
- In Vitro Hydrogel-Based Culture of PDXs Enable the extended laboratory culture of cancer PDXs and other primary cells in 3D.
- Organotypic Culture Co-culture different cells to enable in vitro growth of an in vivo tissue or organ equivalent.
- Signaling Pathways Find proteins, assays and custom reagents for the analysis of cell signaling pathways.
Show all 7 in Cell Culture and Characterization
- Single Cell Services Request services to perform genomics, transcriptomics, proteomics, metabolomics and cell–cell interactions at the single cell level
Show all 78 services
Disease Models
- Acute Lung Injury Models Measure therapeutic endpoints in animal models of acute lung injury.
- Liver Fibrosis Models Measure liver fibrosis using therapeutic endpoints such as collagen assessment, TUNEL staining and inflammatory markers.
- Pulmonary Fibrosis Models Measure therapeutic endpoints in animal models of pulmonary fibrosis.
- Respiratory Models Test therapeutic efficacy of drug candidate in respiratory disease model.
Human Biological Samples
- Custom PDX models For requesting Custom PDX models
- Existing PDX models For requesting Existing PDX models
In Vitro ADME
- Cell Permeability and Absorbance Models Cell Permeability and Absorbance Model assay.
- Compound Distribution Determine the metabolic fate of a drug candidate in tissue and organs of diseased and normal animal models.
In Vitro Assays
- 3D Cell Microscopy Assay Investigate cellular and subcellular events in three dimensional 3D cultures by using fluorescence microscopy.
- Apoptosis Assays Detect apoptotic events that lead to programmed cell death.
- Apoptotic Cell Staining Detect apoptotic cells in culture.
- Assay Development Construct or create new assays or modify existing ones.
- Caspase Assay Detect early to mid stage apoptosis or differentiate apoptosis from necrosis.
- Cell Based Assays Apply compounds to cells and test for cellular phenotypes and effects on gene expression
Show all 21 in In Vitro Assays
- Cell Based Assays Consulting Expert advice to evaluate the functions of specific chemicals based on their constructions and systems.
- Cell Cycle Assays Measure cell cycle markers and the molecular events that control cell cycle progression.
- Cell Proliferation Measure cell number, cell viability and cell division.
- High Content Screening Analyze whole cells or components of cells with simultaneous readout of several parameters.
- In Vitro Assay Development Develop innovative assay and screening methods outside a living organism to enable a wide range of pre-clinical activities.
- Inflammation Assays Identify and validate pro- and anti-inflammatory molecules, recruitment inhibitors and chemotaxis modulators.
- Invasion Assays Monitor and quantify the ability of cultured cells to permeate real or artificial biological barriers.
- Lipid Detection Use in vitro methods to identify lipid droplets and any associated proteins.
- Lipolysis Measure the hydrolysis of triglycerides into glycerol and free fatty acids.
- Oxidative Burst Examine the release of reactive oxygen species (ROS) from neutrophils and other immune cells.
- Pathway Mapping Define mechanisms of action by analyzing protein pathways affected by drug treatment.
- Phenotype Assays Measure effects of drug candidate on the morphology or function of cells and whole animals.
- Reactive Species Assays Use biochemical, cell-based or in vivo assays to detect and evaluate the effects of reactive species.
- Stem Cell Differentiation Microscopy Assay› Elucidate mechanisms of stem cell renewal and differentiation in vitro using fluorescence microscopy.
- Tube Formation Assay Monitor the in vitro formation of three dimensional 3D tube structures.
In Vitro Pharmacology
- Cytotoxic T-Lymphocyte Antigen-4 (CTLA-4) Assays Use biochemical, cell based or in vivo assays to measure CTLA-4 receptor activity.
- Drug Target Assays Gain insight into the selectivity and mode-of-action of a compound's pharmacological targets.
- Histone Deacetylase (HDAC) Assays Use biochemical, cell-based or in vivo assays to measure histone deacetylase activity.
- Immuno-oncology Assays Use biochemical, cell based or in vivo assays to measure the activity of immuno-therapy targets.
- Immuno-oncology Targets Develop drugs that take advantage of the immune system to target cancer cells.
- In Vitro Disease Models Screen pre-clinical candidates without the use of live animals.
Show all 18 in In Vitro Pharmacology
- In Vitro Hepatotoxicity Assays Use in vitro assays to measure hepatoxicity-related activities.
- In Vitro Hypoxia Models Use in vitro models to measure therapeutic endpoints associated with hypoxia.
- In Vitro Neural Models Use cultured neurons, neuronal progenitor cells and stem cell differentiation to create cellular models of neurological disease.
- In Vitro Oncology Models Use cell-based and biochemical models of cancer.
- Kinase Assays Measure activity of over 500 kinases in biochemical or cell-based assays.
- Nuclear Receptor Assays Measure nuclear receptor activity in biochemical and cell assays.
- PARP Assays Use biochemical, cell-based or in vivo assays to measure PARP activity.
- Programmed Death-Ligand 2 (PD-L2) Assays Use biochemical, cell based or in vivo assays to monitor competitive or non-competitive binding of PD-L2 ligand.
- Protein/Enzyme Targets For requesting Protein/Enzyme Targets
- Target Characterization Characterize potential drug targets during the drug discovery process.
- Target Identification Identify the target(s) of a biologically active substance.
- Target Validation Demonstrate that modification of target activity has potential therapeutic benefits.
In Vitro Toxicology
- Cardiomyocyte Toxicity Assess cytotoxic effects of pre-clinical compounds on cardiomyocytes.
- Cardiovascular Toxicology Measure the toxic effects of pre-clinical compounds.
- Cytotoxicity Test for effects on cell viability and proliferation
- Endothelial Cell Toxicity Assess the cytotoxic effects of pre-clinical compounds on the vascular system.
- HepaRG Cells Obtain terminally differentiated and cryopreserved hepatic cells that retain many characteristics of primary human hepatocytes.
- Tubule Epithelial Cell Toxicity Assess the cytotoxic effects of pre-clinical compounds on the kidney.
In Vivo Pharmacokinetics
- Maximum Tolerated Dose (MTD) Studies Determine Maximum Tolerated Dose (MTD) of a drug candidate in either a single or repetitive dosing study in a rodent (typically mouse or rat).
Oncology Models
- Immuno-PDX Utilize the patient-derived xenograft for drug response profiling and biomarker discovery of immuno-oncology drug candidates.
- Leukemia PDX Measure therapeutic endpoints in patient-derived xenografts of leukemia.
- Nervous System PDX Patient derived xenografts relating to the components of the Nervous System. This includes PDX from the Brain, Spinal Cord, and Nerves.
- Oncology Derived PDX Patient derived xenografts derived from various oncological samples. This includes, but is not limited to, samples from Lymphoma, Melanoma, and Leukemia.
REACH Services
- Hazard, Exposure and Risk Assessment Evaluate the known hazard of a test compound in conjunction with the expected quantity and frequency of exposure.
Safety Pharmacology
- CNS Behavioral Measure safety toxicology effects of CNS and behavioral drugs.
Other services
- Integrated Human Biospecimen Package Utilize a Human Biospecimen Pipeline Package to process or characterize Human Biological Samples including: Sample Preparation, Histochemistry, Hybridization, Sequencing, Cell Based Assays, and Sample Bioanalysis from...
- New Request
Where it operates
Sites by country, with the cities in each.
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United States 1 site
About this supplier
In the supplier's own words, as listed in the Scientist.com network.
PhenoVista Biosciences LLC is a privately held company formed in 2014 by a pair of cell biologists. We are headquartered in the Sorrento Vallely district of San Diego, California. Our facilities include state-of-the-art wet labs with tissue culture and automated liquid handling capabilities. Our analytical capabilities include several best of brand automated fluorescence microscopes and high content screening (HCS) instruments coupled with proprietary analysis and visualization software developed in-house and with our technology partners.
- Professional associations
- BIOCOM, LRIG, MassBio, SOT, Society of Biomolecular Imaging and Informatics (SBI2), Society of Laboratory Automation and Screening (SLAS)
- Website
- phenovista.com
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