Ohio State University - Proteomics Core

The Proteomics Shared Resource (PSR) provides OSUCCC investigators access to advanced mass spectrometry instrumentation and analysis for protein identification, characterization, and quantification. Using a variety of analytical platforms, researchers are able to discover novel differentially expressed proteins in serum, urine, BAL fluid, saliva, frozen tissues, formalin-fixed tissues and cell lysates. The PSR is part of the Campus Chemical Instrument Center managed by the OSU Office of Research, with significant operational management by the OSUCCC. The PSR is located within OSUCCC space in the Biomedical Research Tower. The Proteomics Shared Resource (PSR) is an interdisciplinary unit that provides cancer researchers with technical expertise and state-of-the-art instrumentation needed to identify proteins, protein modifications, protein interactions and protein biomarkers as well as protein quantitation studies in cancer samples. The PSR can identify proteins from solution, 1D and 2D gels using electrophoresis and imaging equipment, robotic sample handlers and (tandem) mass spectrometers.

Proteomic Shared Resource Goals

Provide a high-quality, affordable service for identifying proteins, protein modifications, protein interactions and protein biomarkers as well as protein quantitation studies
Provide consultative services and technical assistance in experimental design and implementation in protein sample preparation, separation and purification, as well as in image analysis, mass spectrometry and data mining
Provide education and training for basic and clinical investigators in proteomics analysis applications and capabilities
Provide advanced methods of sample pre-fractionation prior to mass spectrometric analysis and protein identification
Provide for the analysis of complex mixtures of proteins by 2D-HPLC and tandem mass spectrometry, especially for evaluating protein and chemical biomarkers for cancer and therapeutic regimens