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Confluence Discovery Technologies
Confluence Discovery Technologies is listed as a small business research supplier in the Scientist.com network, with 1 site in 1 country and 2 service areas.
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Sites
1
Countries
1
Services
What this research supplier says it provides, as listed in the Scientist.com network.
Type of company: Small business
Bioimaging
- Luminescence Imaging Monitor biological processes and pathologies using reporter proteins such as firefly and Renilla luciferase.
Biomarkers
- Biomarker Discovery Identify a biomarker associated with disease progression of disease, effectiveness of therapy or diagnosis of disease or condition.
- Biomarker Services Evaluating normal/abnormal biological conditions and characteristics within the body
- Cytokine Release Assay Use in vivo or in vitro assays to detect unregulated or excessive release of pro-inflammatory cytokines.
- Flow Cytometry Identify fluorescently-labeled cells or physically separate cells from a larger population using biomarkers.
- Human Primary Cell Isolation Isolate primary cells from various human tissues.
- Immunoassays Create antibody-based assays for the identification and quantification of specific antigens.
Show all 7 in Biomarkers
- Predictive Biomarkers Discovery Identify candidate biomarkers suggestive of a response to a treatment.
Cell Culture and Characterization
- Cell Culture Culture primary or immortalized cell lines.
- Cell Transfection Produce, package and optimize transfection of your siRNA or DNA construct.
- Recombinant Technology Manipulate genotypes to introduce or modify the expression of specific cell products or physical traits.
- Signaling Pathways Find proteins, assays and custom reagents for the analysis of cell signaling pathways.
Chemical and Compound Analysis
- Isothermal Titration Calorimetry An ITC assay will be established and optimised for the affinity measurement of test substance to target molecule.
Show all 41 services
Discovery Chemistry
- Discovery Computational Chemistry Model the interaction of a drug candidate with protein targets such as kinases, GPCRs, receptors, ion channels or enzymes.
- LCMS Analysis Physically separate substances using liquid chromatography and mass spectrometry.
- QSAR Analysis Develop quantitative structure–activity relationship models for drug design.
- Virtual Screening Use software algorithms to virtually screen millions of potential compounds and peptides for binding.
Disease Models
- Arthritis Models Measure therapeutic endpoints in animal models of arthritis.
DNA & RNA
- Expression Profiling Measure the the expression of thousands of genes at once to create a global picture of cellular function.
- Genomic DNA Purification Isolate genomic DNA from cells or tissue samples.
- PCR Mutagenesis Use polymerase chain reaction to create mutations in a cloned gene.
- qPCR Analysis Measure the accumulation of PCR products in real time.
General in vivo Toxicology
- General Toxicology Use in vivo models to assess acute and sub-acute toxicity as well as chronic and sub-chronic toxicity.
Human Biological Samples
- Human Whole Blood Acquire fresh/frozen normal whole blood based on patient demographics and history.
In Vitro Assays
- Assay Development Construct or create new assays or modify existing ones.
- Cell Proliferation Measure cell number, cell viability and cell division.
- HTS Assay Development Develop assays to use in high throughput screening.
- In Vitro Efficacy Test Use in vitro models to test the efficacy of your products.
- Inflammation Assays Identify and validate pro- and anti-inflammatory molecules, recruitment inhibitors and chemotaxis modulators.
In Vitro Pharmacology
- Immuno-oncology Assays Use biochemical, cell based or in vivo assays to measure the activity of immuno-therapy targets.
- In Vitro Enzyme Activity Assay Development Develop new in vitro enzyme activity assays or modify existing ones.
- In Vitro Oncology Models Use cell-based and biochemical models of cancer.
- Kinase Assays Measure activity of over 500 kinases in biochemical or cell-based assays.
- Methyltransferase Assays Use biochemical, cell-based or in vitro assays to measure methyltransferase activity.
- Target Validation Demonstrate that modification of target activity has potential therapeutic benefits.
In Vivo Pharmacokinetics
- In Vivo Pharmacokinetics Run pharmacokinetic studies in animals that measure a drug's absorption, distribution, metabolism and excretion (ADME).
Oncology Models
- Xenograft Models Measure therapeutic endpoints in cancer models using tumor cells transplanted from a donor of a different species.
Protein Sciences
- Cytokines Find recombinant cytokines or cytokine assays.
- Protein Binding Determine drug-protein binding interactions
- Protein Purification Isolate native or recombinant proteins from a sample.
- Surface Plasmon Resonance (SPR) Measure interactions of biomolecules including antibodies, vaccines, biomarkers and small molecules.
Service areas:
Biology
Chemistry
Where it operates
Sites by country, with the cities in each.
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United States 1 site
About this supplier
In the supplier's own words, as listed in the Scientist.com network.
Confluence Discovery Technologies provides medicinal chemistry design, biomarker assays, assay development, and drug target interaction services.
- Website
- confluencediscovery.com
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