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DC3 Therapeutics.com
DC3 Therapeutics.com is listed as a small business research supplier in the Scientist.com network, with 1 site in 1 country.
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Services
What this research supplier says it provides, as listed in the Scientist.com network.
Type of company: Small business
Antibodies
- Antibody Sequencing Sequence cDNA encoding variable heavy (VH) and variable light (VL) domains of a hybridoma cell line.
- Hybridoma Sequencing/Antibody Sequencing Determine the sequences of monoclonal antibodies.
- Immunodetection Use antibodies to identify a protein or antigen.
Biomarkers
- Adipogenesis Assay Detect and quantify intracellular triglyceride accumulation in adipocytes.
- Antimicrobial Effectiveness Testing Measure the efficacy of anti-microbial preservatives added to a product.
- Basic Metabolic Profiling Set up assays that monitor drug metabolite formation after administration of drug to an animal model or patient.
- Biomarker Analytical Validation Assess and optimize the characteristics of a candidate biomarker to ensure reproducibility and consistency.
- Biomarker Clinical Utility Evaluate the potential clinical applications of a candidate biomarker.
- Biomarker Clinical Validation Evaluate the predictive ability of a candidate biomarker for a disorder.
Show all 30 in Biomarkers
- Biomarker Discovery Identify a biomarker associated with disease progression of disease, effectiveness of therapy or diagnosis of disease or condition.
- Biomarker Services Evaluating normal/abnormal biological conditions and characteristics within the body
- Cell Migration Assays Measure chemotaxis, haptotaxis, transmigration and wound-healing.
- Cell Viability Measure changes in cell number, cell division, DNA content or a cell metabolism marker such as ATP levels.
- Chemotaxis Assays Investigate the in vivo or in vitro movement of cells towards or away from a chemotactic agent.
- Colony Forming Cell Assay Examine ability of hematopoietic stem cells to form colonies in vitro.
- Cytokine Release Assay Use in vivo or in vitro assays to detect unregulated or excessive release of pro-inflammatory cytokines.
- Diagnostic Biomarkers Discovery Identify candidate biomarkers indicative of the presence of a disorder.
- Flow Cytometry Identify fluorescently-labeled cells or physically separate cells from a larger population using biomarkers.
- Hematoxylin & Eosin (H&E) Staining Visualize microscopic structures in cells or tissues.
- Histamine Release Assay Use in vivo or in vitro assays to measure the release of histamine in response to an allergen stimulation.
- Human Primary Cell Isolation Isolate primary cells from various human tissues.
- Immunostaining Use labeled antibodies to detect proteins or other antigens in cells or tissues.
- Interferon Gamma Release Assay Use in vivo or in vitro assays to measure the cell-mediated immune response to an infectious agent.
- Lipid Peroxidation Assay Use in vitro or in vivo assays to evaluate the effects of oxidative stress on lipid structure and function.
- Microfluidics-Based Biomarker Isolation and Detection Isolate and detect rare biomarkers in blood samples, such as CTCs, cfDNA, and exosomes.
- Pharmacodynamic Biomarkers Discovery Identify candidate biomarkers indicative of the therapeutic outcome of a drug-target interaction.
- Plaque Assays Determine infectious viral titer using plaque-forming units or purify viral stocks.
- Predictive Biomarkers Discovery Identify candidate biomarkers suggestive of a response to a treatment.
- Prognostic Biomarkers Discovery Identify candidate biomarkers representative of disease progression without treatment.
- Special Stainings Use a variety of techniques for the selective visualization of specific tissue or cell types.
- TUNEL Assay Detect in situ DNA fragmentation.
- Whole Transcriptome Amplification Amplify total RNA from a single cell.
- Wound Healing Assay Use cell-based assays to investigate cell proliferation, cell migration and wound closure.
Cell Culture and Characterization
- 3D Cell Culture Use a scaffold-based or scaffold-free format to grow three dimensional cell and tissue structures.
- Adherent Cell Culture Grow monolayers of anchorage-dependent cells.
- Bacterial Cell Culture Culture and Grow bacterial cells.
- Cell and Tissue Histology Prepare and stain frozen, fixed and embedded (FFPE) tissue samples.
- Cell Line Construction Create new recombinant cell lines to exact specifications.
- Cell Transfection Produce, package and optimize transfection of your siRNA or DNA construct.
Show all 12 in Cell Culture and Characterization
- Cryo-based Histology Perform sectioning and histological analysis of frozen non-fixed samples.
- Human Melanoma Cell Lines Obtain highly characterized cell lines derived from patients’ tumors for in vitro and in vivo modelling.
- Insect Tissue Culture Grow insect cells.
- Recombinant Technology Manipulate genotypes to introduce or modify the expression of specific cell products or physical traits.
- Resin-based Histology Perform sectioning and histological analysis of epoxy/acrylic/polycarbonate-embedded samples.
- RNA-Based Transfection Deliver RNA to cells by microinjection, electroporation or lipid-mediated transfection.
Show all 116 services
Chemical and Compound Analysis
- Solubility Studies Analyze substances for kinetics of solubility using nephelometry and UV-Vis spectrometry.
- UV-Spectroscopy Conduct sample analysis based on light absorption and transmission.
Chemistry, Manufacturing and Controls (CMC)
- Chemistry, Manufacturing and Controls (CMC) Request Chemistry, Manufacturing and Controls services
Clinical Consulting
- Biomarker Services Consulting Expert advice to conduct solutions for evaluating normal/abnormal biological conditions and characteristics within the body.
- Cell Services Consulting Whether you are an experienced drug hunter working in the pharmaceutical industry or an academic researcher looking to submit g...
DNA & RNA
- Amplicon 16s rRNA Sequencing Identify and compare bacteria present within a given sample.
- Cell Free DNA Assay Detect known mutations and discover new ones in cell-free plasma DNA.
- ChIP-Sequencing Use chromosome immunoprecipitation to identify DNA-protein binding sites in a genome.
- ChIP-sequencing Profiling Identify where a protein is binding to DNA on a genome-wide scale.
- ddPCR-Based Plasma Genotyping Perform noninvasive tumor genotyping.
- DNA Library Screening Screen genomic or cDNA libraries for positive clones.
Show all 25 in DNA & RNA
- DNA Products Find DNA products including gDNA, cDNA clones, vectors and constructs from mice, insects, yeast, bacteria and viruses.
- Exome Sequencing Determine protein-coding nucleotide sequences in a DNA sample.
- Expression Profiling Measure the the expression of thousands of genes at once to create a global picture of cellular function.
- Genome Editing Use CRISPR, ZFN, TALEN or AAV gene targeting for targeted gene mutations and creation of transgenics.
- Genotyping Examine a DNA sequence to identify specific genetic varients .
- miRNA sequencing Identify miRNAs by Next Generation Sequencing and bioinformatic analysis.
- mtDNA Sequencing Use next-generation sequencing (NGS) technology to detect and analyze mitochondrial mutations.
- PCR Mutagenesis Use polymerase chain reaction to create mutations in a cloned gene.
- qPCR Analysis Measure the accumulation of PCR products in real time.
- Quantitative RT PCR Use quantitative reverse transcription polymerase chain reaction to measure absolute and relative mRNA abundance.
- RNA Extraction Isolate total RNA or mRNA from cells or tissues
- RNA Profiling Quantify the expression levels of mRNA transcripts, enabling the determination of gene expression patterns.
- RNA Sequencing/Resequencing Identify RNA transcripts, examine differential expression patterns and analyze splice variants.
- Sanger Sequencing Sequence single strand DNA fragments using DNA Polymerase.
- SNP Characterization Identify single nucleotide polymorphisms to make genetic associations, analyze disease SNPs and determine LOH.
- Total RNA Sequencing Identify novel RNA transcripts and detect gene expression changes.
- Whole Genome Amplification (WGA) Amplify an entire genome from a single cell.
- Whole Genome Profiling Develop sequence-based physical maps for the assembly of genomes.
- Whole Genome Sequencing Determine the entire genetic make-up of an organism.
Drug Development
- Assay Development Consulting Request consultant services measuring the activity of a drug or biochemical in an organism or organic sample.
In Vitro ADME
- Cell Fractionation Isolate organelles and subcellular components.
In Vitro Assays
- Annexin V Apoptosis Assay Detect and quantify apoptotic cells based on loss of membrane asymmetry.
- Antivirals Measure anti-viral activity in biochemical and cell assays.
- Apoptosis Assays Detect apoptotic events that lead to programmed cell death.
- Apoptotic Cell Staining Detect apoptotic cells in culture.
- Caspase Assay Detect early to mid stage apoptosis or differentiate apoptosis from necrosis.
- Cell Based Assays Apply compounds to cells and test for cellular phenotypes and effects on gene expression
Show all 17 in In Vitro Assays
- Cell Based Assays Consulting Expert advice to evaluate the functions of specific chemicals based on their constructions and systems.
- Cell Proliferation Measure cell number, cell viability and cell division.
- ELISpot Assay and Testing Detect low levels of antigens.
- Endpoint Dilution Assay (TCID50) Assay Determine the viral titer to induce cell death in half the cell population of an inoculated tissue culture.
- Glucose Release Assay Determine free glucose levels in biological samples.
- Glucose Uptake Measure glucose uptake in cultured cells using GLUT4 signaling assays.
- HTS Assay Development Develop assays to use in high throughput screening.
- Inflammation Assays Identify and validate pro- and anti-inflammatory molecules, recruitment inhibitors and chemotaxis modulators.
- Luciferase Reporter Assay Evaluate promoter activity by measuring light output from the luciferase enzyme.
- Microbiology Study microbes and their role in human health.
- Phenotype Assays Measure effects of drug candidate on the morphology or function of cells and whole animals.
In Vitro Pharmacology
- Calcium Channel Assays Use biochemical, cell-based or in vivo assays to measure calcium channel activity.
- Chloride Channel Assays Use biochemical, cell-based or in vivo assays to measure chloride channel activity.
- Fibroblast Growth Factor Receptor (FGFR) Assays Use biochemical, cell based or in vivo assays to measure FGF receptor activity.
- G-Protein Coupled Receptor (GPCR) Assays Detect ligand binding, receptor dimerization and downstream signal transduction events.
- High Throughput Screening Conduct millions of chemical, genetic or pharmacological tests in a short period of time.
- Human Epidermal growth factor Receptor (HER) Assays Use biochemical, cell based or in vivo assays to measure HER receptor activity.
Show all 14 in In Vitro Pharmacology
- In Vitro Enzyme Activity Assay Development Develop new in vitro enzyme activity assays or modify existing ones.
- In Vitro Oncology Models Use cell-based and biochemical models of cancer.
- Kinase Assays Measure activity of over 500 kinases in biochemical or cell-based assays.
- Polymerase Assays Measure polymerase activity in biochemical and cell-based assays.
- Potassium Channel Assays Use biochemical, cell-based or in vivo assays to measure potassium channel activity.
- Programmed Cell Death-1 (PD-1) Assays Use biochemical, cell based or in vivo assays to measure PD-1 receptor activity.
- Sodium Channel Assays Use biochemical, cell-based or in vivo assays to measure sodium channel activity.
- Time Dependent Study Determine whether or not a compound binds to an enzyme in a time-dependent manner.
In Vitro Toxicology
- ADCC and CDC Assay Services Measure toxicity of antibodies.
- Cytotoxicity Test for effects on cell viability and proliferation
Lab Supplies, Facilities, and Equipment
- Biobanking Store and track biological samples.
Other Specialty Toxicology
- Microdilution Testing Simultaneously quantify the susceptibility of a microbial species or strain to multiple anti-microbial agents.
Protein Sciences
- Bacterial Expression Produce milligram, gram and kilogram amounts of proteins.
- Cytokines Find recombinant cytokines or cytokine assays.
- Mammalian Expression Express high yields of recombinant proteins, antibodies, virus, viral-subunit proteins and gene-therapy vectors.
Other services
- New Request
Where it operates
Sites by country, with the cities in each.
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United States 1 site
About this supplier
In the supplier's own words, as listed in the Scientist.com network.
We are a full service CRO located in South San Francisco. Our services include; assay development (biochemical, cell based), assay optimization, molecular biology (Sequencing (NGS and Sanger), qPCR, cloning, cell line development (Lentiviral/CRISPR), ELISA's , Multiplex ELISA, Western Blots, IP's). We also offer histology and microbiological services. DC3 Therapeutics is GLP compliant.
- Website
- www.dc3therapeutics.com
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