Hesperos, Inc.

Hesperos, Inc. is listed as a small business research supplier in the Scientist.com network, with 3 sites in 1 country.

Search companies, drugs, suppliers and investigators, and follow each one to the others. Individual plan, $249/seat/mo. Card required.

Sites 3

Countries 1

Type of company: Small business

Biomarkers

Cell Viability Measure changes in cell number, cell division, DNA content or a cell metabolism marker such as ATP levels.

Chemical and Compound Analysis

High Resolution MS Elucidate the sequence and structure of peptides, proteins, biomarkers and organic compounds.
NMR Structure Determine molecular structure, identify chemical impurities and validate sample integrity.
Non GLP Small Molecule Bioanalysis Detect and analyze the pharmacokinetic profile of small molecules.
Solubility Studies Analyze substances for kinetics of solubility using nephelometry and UV-Vis spectrometry.

Discovery Chemistry

Compound Synthesis Synthesize small molecule candidates for use in hit followup, lead optimization and medicinal chemistry.
Compound Synthesis Services (IP-sensitive) Synthesize small molecule candidates for use in hit followup, lead optimization and medicinal chemistry.
Custom Libraries Find or synthesize mg to kg amounts of target-specific and target-agnostic compounds for HTS and biological profiling.
Hit to Lead (H2L) Evaluate, perform limited optimization and identify small molecule hits from high throughput screens.
LCMS Analysis Physically separate substances using liquid chromatography and mass spectrometry.
Lead Optimization Perform chemical structural changes to improve preclinical drug candidate.

Effectiveness

In Vitro Dose Determination Tests Determine the most appropriate effective drug dosage regimen(s) in vitro.

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Human Biological Samples

Human Organs-On-Chips Use Organs-On-Chips for target identification and validation, target-based screening, and phenotypic screening.

In Vitro ADME

Blood Brain Barrier Measure movement of drugs from circulating blood to brain extracellular fluid.
Caco-2 Cell Permeability Measure passive diffusion of drugs across Caco2 cell monolayers.
Cell Permeability and Absorbance Models Cell Permeability and Absorbance Model assay.
CYP Induction Detect increases in the expression of various isoforms of cytochrome P450 (CYP450).
CYP Inhibition Assay Assess the inactivation and inhibition of cytochrome P450 (CYP450) in microsomes isolated from primary human hepatocytes or liver.
Drug Distribution Studies Determine the metabolic fate of compounds within tissues, organs and plasma.

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Human Blood Brain Barrier on a Chip (BBBoC) Create a blood–brain barrier multicellular model to test drug delivery to the brain.
In Vitro ADME in Vitro ADME services
Intestinal Permeability Use Caco 2 and MCDK cells to assess mono-directional drug transport by passive diffusion in culture.
Metabolic Stability in Microsomes Assess the susceptibility of drugs to metabolism by Phase I (CYP450) and Phase II enzymes in liver microsomes.
Plasma Stability Assay Determine degradation rate of drug candidates in plasma.
Skin Permeability Use human skin models to determine transdermal delivery and percutaneous absorption of pre-clinical drugs.

In Vitro Assays

Assay Development Construct or create new assays or modify existing ones.
Biosensor Assays Evaluate biological activity of new compounds, detect toxic metabolites or monitor biomarkers.
Cell Based Assays Apply compounds to cells and test for cellular phenotypes and effects on gene expression
Cell Proliferation Measure cell number, cell viability and cell division.
Cell-based Screening Assays Apply compounds to cells and test for cellular phenotypes and effects on gene expression
High Content Screening Analyze whole cells or components of cells with simultaneous readout of several parameters.

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HTS Assay Development Develop assays to use in high throughput screening.
In Vitro Assay Development Develop innovative assay and screening methods outside a living organism to enable a wide range of pre-clinical activities.
In Vitro Efficacy Test Use in vitro models to test the efficacy of your products.
In Vitro Human Cell Assays Request in vitro human cells for assays
Inflammation Assays Identify and validate pro- and anti-inflammatory molecules, recruitment inhibitors and chemotaxis modulators.
Organoid Screening Assay Evaluate the effects of various substances, such as drugs or genetic modifications, on organoids.
Phenotype Assays Measure effects of drug candidate on the morphology or function of cells and whole animals.
Reactive Species Assays Use biochemical, cell-based or in vivo assays to detect and evaluate the effects of reactive species.

In Vitro Pharmacology

Drug Target Assays Gain insight into the selectivity and mode-of-action of a compound's pharmacological targets.
G-Protein Coupled Receptor (GPCR) Assays Detect ligand binding, receptor dimerization and downstream signal transduction events.
High Throughput Screening Conduct millions of chemical, genetic or pharmacological tests in a short period of time.
In Vitro Disease Models Screen pre-clinical candidates without the use of live animals.
Protease Assay Measure protease activity in biochemical and cell-based assays.

In Vitro Toxicology

Cardiac Channels Measure the arrhythmia producing potential of test compounds.
Cytotoxicity Test for effects on cell viability and proliferation
Toxicology- in vitro Toxicity testing and model development in vitro on developmental and adult neurotoxicity

Protein Sciences

Cytokines Find recombinant cytokines or cytokine assays.

Testing Services

In Vitro Toxicology Testing Non-animal testing employing US and international methodologies for determining irritation and other undesirable potentials.
Membrane Permeability (PAMPA) Parallel Artificial Membrane Permeability Assay (PAMPA) - Measure passive diffusion of drugs by the parallel artificial membrane permeation assay.

Website: www.hesperosinc.com

United States Orlando 3 sites

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