- Supplier site
- Group of sites (click to zoom)
Scientist.com supplier network (site locations)
Research supplier
Buffalo BioLabs
Buffalo BioLabs is listed as a small business research supplier in the Scientist.com network, with 1 site in 1 country.
Sign in to Scientist.com to open this supplier in your organization's marketplace.
Search companies, drugs, suppliers and investigators, and follow each one to the others. Individual plan, $249/seat/mo. Card required.
Services
What this research supplier says it provides, as listed in the Scientist.com network.
Type of company: Small business
Bioimaging
- Luminescence Imaging Monitor biological processes and pathologies using reporter proteins such as firefly and Renilla luciferase.
Biomarkers
- Cell Viability Measure changes in cell number, cell division, DNA content or a cell metabolism marker such as ATP levels.
- Colony Forming Cell Assay Examine ability of hematopoietic stem cells to form colonies in vitro.
- Cytokine Release Assay Use in vivo or in vitro assays to detect unregulated or excessive release of pro-inflammatory cytokines.
- Flow Cytometry Identify fluorescently-labeled cells or physically separate cells from a larger population using biomarkers.
- Histopathology Evaluate slide preparation of cells or tissues for abnormal features.
- Immunohistochemistry Examine the toxic effects of pre-clinical compounds in small animal and patient histological samples.
Show all 10 in Biomarkers
- Immunostaining Use labeled antibodies to detect proteins or other antigens in cells or tissues.
- Paraffin-based Histology Perform sectioning and histological analysis of wax-embedded samples.
- Single Cell quantitative Real Time-PCR Assess gene expression levels and patterns in a single cell.
- Special Stainings Use a variety of techniques for the selective visualization of specific tissue or cell types.
Cell Culture and Characterization
- Adherent Cell Culture Grow monolayers of anchorage-dependent cells.
- Bacterial Cell Culture Culture and Grow bacterial cells.
- Cell and Tissue Histology Prepare and stain frozen, fixed and embedded (FFPE) tissue samples.
- Cell Culture Culture primary or immortalized cell lines.
- Cell Transfection Produce, package and optimize transfection of your siRNA or DNA construct.
- Cryo-based Histology Perform sectioning and histological analysis of frozen non-fixed samples.
Show all 9 in Cell Culture and Characterization
- Recombinant Technology Manipulate genotypes to introduce or modify the expression of specific cell products or physical traits.
- RNA-Based Transfection Deliver RNA to cells by microinjection, electroporation or lipid-mediated transfection.
- Trichrome Staining Use a variety of techniques for the selective visualization of muscle, collagen fibers, fibrin and erythrocytes.
Show all 67 services
Chemistry, Manufacturing and Controls (CMC)
- Drug Formulation Combine substances including the active drug into a final product with the desired metabolic and therapeutic properties.
- Formulation Development Optimize bioavailability, stability, salt forms, plasma stability and excipient release in vivo.
Disease Models
- LPS Acute Response Models Measure therapeutic endpoints in acute models of inflammation.
DNA & RNA
- Quantitative RT PCR Use quantitative reverse transcription polymerase chain reaction to measure absolute and relative mRNA abundance.
- Target Gene Expression Measure expression of a target gene at the protein, RNA and DNA level.
General in vivo Toxicology
- Carcinogenicity Study - Mouse Conduct a repeat dose, chronic carcinogenicity study in mice to determine the tendency of your compound to produce tumors.
- Carcinogenicity Study - Rat Conduct a repeat dose, chronic carcinogenicity study in rats to determine the tendency of your compound to produce tumors.
- Dose Range Finding Study - Mouse Conduct a study to determine the dose range of your compound in mice.
- Dose Range Finding Study - Rat Conduct a study to determine the dose range of your compound in rats.
- General Toxicology Use in vivo models to assess acute and sub-acute toxicity as well as chronic and sub-chronic toxicity.
- Oral Toxicology Use toxicity studies in animals to evaluate the oral toxicity of a drug candidate.
Show all 11 in General in vivo Toxicology
- Repeat Dose Toxicity Study - Mouse Conduct a repeat dose study in mice to determine the toxicity and toxicokinetic behavior of your compound.
- Repeat Dose Toxicity Study - Rat Conduct a repeat dose study in rats to determine the toxicity and toxicokinetic behavior of your compound.
- Single Dose Acute Toxicity Study - Mouse Conduct a single dose study in Mice and Murines to determine the toxicokinetic behavior of your compound.
- Single Maximum Tolerated Dose (MTD) Mouse Study Use mouse models to determine the MTD of a drug candidate by a single administration in a 7 day period.
- Single Maximum Tolerated Dose (MTD) Rat Study Use rat models to determine the MTD of a drug candidate by a single administration in a 7 day period.
In Vitro Assays
- Assay Development Construct or create new assays or modify existing ones.
- Cell Based Assays Apply compounds to cells and test for cellular phenotypes and effects on gene expression
- Cell Based Assays Consulting Expert advice to evaluate the functions of specific chemicals based on their constructions and systems.
- Cell Proliferation Measure cell number, cell viability and cell division.
- In Vitro Assay Development Develop innovative assay and screening methods outside a living organism to enable a wide range of pre-clinical activities.
In Vitro Pharmacology
- High Throughput Screening Conduct millions of chemical, genetic or pharmacological tests in a short period of time.
- In Vitro Oncology Models Use cell-based and biochemical models of cancer.
In Vitro Toxicology
- Cytotoxicity Test for effects on cell viability and proliferation
In Vivo Pharmacokinetics
- In Vivo Pharmacokinetics Run pharmacokinetic studies in animals that measure a drug's absorption, distribution, metabolism and excretion (ADME).
- Maximum Tolerated Dose (MTD) Studies Determine Maximum Tolerated Dose (MTD) of a drug candidate in either a single or repetitive dosing study in a rodent (typically mouse or rat).
- Pharmacokinetic (PK) Screening - Mouse Run pharmacokinetic studies in mice that measure a drug's absorption, distribution, metabolism and excretion.
- Pharmacokinetic (PK) Screening - Rat Run pharmacokinetic studies in rats that measure a drug's absorption, distribution, metabolism and excretion.
- Rat Efficacy Combination Use rat models to determine the anti-cancer efficacy and potential synergy of a drug candidate with a standard drug treatment.
- Rat Efficacy Monotherapy Use rat models to determine the anti-cancer efficacy of a drug candidate compared to a positive control.
Show all 8 in In Vivo Pharmacokinetics
- Repetitive Maximum Tolerated Dose (MTD) Mouse Study Use mouse models to determine the MTD of a drug candidate by repetitive administrations for 7 days.
- Repetitive Maximum Tolerated Dose (MTD) Rat Study Use rat models to determine the MTD of a drug candidate by repetitive administrations for 7 days.
Model Development
- Animal Model Development Create new systems for profiling pre-clinical therapeutics, devices, and surgical techniques.
- SCID Mouse Use a single animal species to create one or more disease models for spontaneous and metastatic cancer and cachexia.
- SCID/BG Mouse Use a single animal species to create one or more disease models for metastatic cancer.
- Sprague Dawley Rat Use a single animal species to create one or more disease models for cachexia.
- Standard Models Create new animal disease models or modify existing models to study specific diseases, side-effects or symptoms.
Oncology Models
- Athymic Mouse Use a single animal species to create one or more disease models for cachexia and spontaneous cancer.
- Oncology Models Use model organisms to test the therapeutic efficacy of cancer drug candidates.
- Oral Xenograft Measure therapeutic endpoints in oral cancer models as well as cancer models related to the Pharynx.
- Ovarian Cancer Mouse Measure therapeutic endpoints in animal models of ovarian cancer.
- Xenograft Models Measure therapeutic endpoints in cancer models using tumor cells transplanted from a donor of a different species.
Safety Pharmacology
- Immunotoxicity Measure effects of drugs on immune function, allergic hypersensitization and autoimmune toxicity.
- Off Target Effects Assess toxicities by body weight, clinical chemistry, hematology, urinalysis and terminal necropsy and pathology.
- Target Safety Assessment Understand the role of your drug target and assess risks in normal physiology.
Testing Services
- In Vitro Skin Models Measure skin model penetration and invasion, photosensitivity and toxicity.
Other services
- New Request
Where it operates
Sites by country, with the cities in each.
-
United States 1 site
About this supplier
In the supplier's own words, as listed in the Scientist.com network.
*Buffalo BioLabs, LLC *(BBL) is a preclinical Contract Research Organization (CRO) experienced in management and performance of in vitro and in vivo studies bringing new therapeutic agents to the stage of clinical testing. We have been providing services for a number of biotech/pharma clients and are looking to expand our customer base. Our scientists and technicians are top notch, working in partnerships with each client to ensure we provide a more personalized experience than some of our larger competitors whom tend to provide only "cookie cutter" type services. BBL is headquartered...
Show the full description
*Buffalo BioLabs, LLC *(BBL) is a preclinical Contract Research Organization (CRO) experienced in management and performance of in vitro and in vivo studies bringing new therapeutic agents to the stage of clinical testing.
We have been providing services for a number of biotech/pharma clients and are looking to expand our customer base. Our scientists and technicians are top notch, working in partnerships with each client to ensure we provide a more personalized experience than some of our larger competitors whom tend to provide only "cookie cutter" type services.
BBL is headquartered in Buffalo, New York on the Buffalo Niagara Medical Campus. We maintain a close collaboration with Roswell Park Cancer Institute, located adjacent to our facility with access to research and clinical expertise and a variety of state-of-the-art resources that greatly enhance our capabilities.
BBL’s focus is preclinical toxicity and efficacy testing in rodents using both conventional and custom models. Our team, including more than 15 graduate level scientists functioning both as project directors and research staff, have experience in all aspects of drug development from drug discovery and mechanistic analysis to pre-clinical animal studies (determination of MTD, in vivo proof of principle efficacy, optimal treatment regimens, effects in combination studies).
Buffalo BioLabs consists of four specialized labs each led by a qualified PI and supported by our animal resource, histology and chemistry cores
You can find a more detailed description of our expertise and offerings at our website www.buffalobiolabs.com where you can find a link to our brochure. I encourage you to contact us directly and schedule a call or in-person meeting with our team to further discuss how we can use our established infrastructure and experience to produce timely and cost-effective results.
We look forward to hearing from you!
- Website
- www.buffalobiolabs.com
Work with Buffalo BioLabs on Scientist.com
For prices, more details, or to contact Buffalo BioLabs, visit Scientist.com.
Sign in to Scientist.com to open this supplier in your organization's marketplace.