SIA ChemSpace

SIA ChemSpace is listed as a small business research supplier in the Scientist.com network, with 2 sites in 2 countries.

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Search companies, drugs, suppliers and investigators, and follow each one to the others. Individual plan, $249/seat/mo. Card required.

Sites 2

Countries 2

Type of company: Small business

Building Blocks Find chemicals used for creating new compound chemotypes and HTS libraries.
Compound Docking Identify potential compound hits based on the 3D structure of a target protein.
Compound Purchase Buy compounds, building blocks or compound libraries.
Compound Purchase Consulting Buy compounds, building blocks or compound libraries.
Compound Synthesis Synthesize small molecule candidates for use in hit followup, lead optimization and medicinal chemistry.
Custom Building Blocks Find or synthesize mg to kg amounts of chemical building blocks, scaffolds and reactive intermediates.

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Discovery Computational Chemistry Model the interaction of a drug candidate with protein targets such as kinases, GPCRs, receptors, ion channels or enzymes.
Fragment Libraries Find fragment libraries for screening against a protein or cellular target.
Hit to Lead (H2L) Evaluate, perform limited optimization and identify small molecule hits from high throughput screens.
HTS Libraries Find targeted and broad collections of chemical compounds for high throughput screening and ADMET applications.
Lead Optimization Perform chemical structural changes to improve preclinical drug candidate.
Library Design & Evaluation Use structural knowledge to design target-focused compound libraries for screening.
Pharmaceutical Research Chemicals Acquire chemicals that are prospective new drug entities.
Pharmacophore Modeling Use computer models to identify hits based on structural similarity to known active compounds.
Target-Focused Compound Libraries Find activity-based libraries directed towards a protein or cell signaling target.
Virtual Screening Use software algorithms to virtually screen millions of potential compounds and peptides for binding.

CYP Inhibition Assay Assess the inactivation and inhibition of cytochrome P450 (CYP450) in microsomes isolated from primary human hepatocytes or liver.
Plasma Stability Assay Determine degradation rate of drug candidates in plasma.

Membrane Permeability (PAMPA) Parallel Artificial Membrane Permeability Assay (PAMPA) - Measure passive diffusion of drugs by the parallel artificial membrane permeation assay.

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