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Friley Consulting, LLC

Friley Consulting, LLC is listed as a small business research supplier in the Scientist.com network, with 2 sites in 1 country.

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Search companies, drugs, suppliers and investigators, and follow each one to the others. Individual plan, $249/seat/mo. Card required.

Sites 2

Countries 1

Type of company: Small business

Antibodies

Antibody Purification Purify multiple antibody types including IgG, IgM, IgA and IgY.
In Vitro Monoclonal Antibody Production Generate monoclonal antibodies in vitro using cultured antibody-secreting hybridoma cell lines.
Phosphospecific Antibodies Create antibodies to detect phosphorylated protein targets.

Bioimaging

In Vivo Whole Tissue and Animal Imaging Visualize, analyze and track light producing reporters in whole animals.
Mass Spectrometry Imaging Visualize the spatial distribution of molecules, as biomarkers, metabolites, peptides or proteins by their molecular masses
Medical Imaging Visualize and analyze internal structures in animal models or patients.

Biomarkers

Biomarker Clinical Utility Evaluate the potential clinical applications of a candidate biomarker.
Biomarker Clinical Validation Evaluate the predictive ability of a candidate biomarker for a disorder.
Biomarker Discovery Identify a biomarker associated with disease progression of disease, effectiveness of therapy or diagnosis of disease or condition.
Biomarker Services Evaluating normal/abnormal biological conditions and characteristics within the body
Cell Viability Measure changes in cell number, cell division, DNA content or a cell metabolism marker such as ATP levels.
Flow Cytometry Identify fluorescently-labeled cells or physically separate cells from a larger population using biomarkers.

Show all 9 in Biomarkers 3 more

Lipid Kinase Assays Use biochemical, cell-based or in vivo assays to measure lipid kinase activity.
Lipid Profiling Use quantitative analysis of blood lipid components to assess cardiac risk.
Metabolomics Biomarker Discovery Identify and quantitate metabolite biomarkers in blood, urine, CSF and bodily fluids.

Show all 210 services 198 more

Cell Culture and Characterization

Cell Culture Culture primary or immortalized cell lines.
Cell Line Construction Create new recombinant cell lines to exact specifications.
Karyotyping Evaluate the number and appearance of chromosomes in the nucleus of a eukaryotic cell.

Chemical and Compound Analysis

Accelerator Mass Spectrometry Detect trace levels of naturally-occurring radionuclides and stable nuclides.
Amino Acid Analysis (AAA) Determine protein quantities, relative compositions and amino acid content profiles.
Atomic Absorption Analysis Measure the elemental composition of a diverse array of samples.
Chiral Separation Purify therapeutically active isomers of drug candidates.
Compound Integrity Analyze the identity and purity of small molecule drug candidates.
Electrophoresis Separate nucleic acids or proteins based on physical properties such as charge or mass.

Show all 26 in Chemical and Compound Analysis 20 more

Field Desorption Mass Spectrometry Use high potential fields to detect intact molecular ions of an analyte.
GLP Large Molecule Bioanalysis Detect and analyze the pharmacokinetic profile of large biomolecules.
GLP Small Molecule Bioanalysis Detect and analyze the pharmacokinetic profile of small molecules.
High Resolution MS Elucidate the sequence and structure of peptides, proteins, biomarkers and organic compounds.
Immunoaffinity Chromatography Use antibody-antigen interactions to isolate and concentrate analytes.
Inductively Coupled Plasma-Mass Spectrometry (ICP-MS) Analysis Detect metals and several non-metals at concentrations as low as one part in 1015 (part per quadrillion, ppq) on non-interfered low-background isotopes.
Ion Exchange Chromatography Separate and detect analytes.
Liquid Chromatography Separate substances using a mobile and stationary phase.
MALDI-TOF Analysis Use mass spectrometry technique to analyze compound, biomolecules and large organic molecules.
Nano-High Performance Liquid Chromatography Separate and detect low levels of analytes.
Non GLP Large Molecule Bioanalysis Detect and analyze the pharmacokinetic profile of large biomolecules.
Non GLP Small Molecule Bioanalysis Detect and analyze the pharmacokinetic profile of small molecules.
Protein Binding HPLC Uses high pressure liquid chromatography to separate protein-drug complexes.
Protein Structure Determine the three dimensional structure of a protein by NMR or x-ray crystallography.
Raman Spectroscopy Use spectroscopic technique to observe vibrational, rotational and other low-frequency modes in a system.
Sample Bioanalysis Determination of concentration of an analyte in biological sample.
Secondary Ion Mass Spectrometry Detect trace level impurities and obtain elemental or molecular chemical data for solid sample surfaces.
Size Exclusion Chromatography Separate and identify analytes based on their molecular size.
Solubility Studies Analyze substances for kinetics of solubility using nephelometry and UV-Vis spectrometry.
Structural Chemistry Examine the relationship between protein structure and function.

Chemistry, Manufacturing and Controls (CMC)

Chemistry, Manufacturing and Controls (CMC) Request Chemistry, Manufacturing and Controls services

Clinical Consulting

Biomarker Services Consulting Expert advice to conduct solutions for evaluating normal/abnormal biological conditions and characteristics within the body.
Biostatistics Consulting Apply statistical theory and mathematical principals to research
Clinical Development Planning Complex document that entails the entire clinical research strategy of a drug, describing the clinical studies that will be carried out for a pharmaceutical entity.
Clinical Protocol Design & Development Creation of clinical protocol document which details how a clinical trial is designed, relating to to the methodology, hypothesis, and operation of clinical trial to ensure the safety of the patients is...
Data & Risk Management Determine the extent of the risk and the reliability of the data used to access the aforementioned risk.
IND Writing Consulting Consulting for an Investigational New Drug Application

Show all 9 in Clinical Consulting 3 more

Product Testing Consulting Expert advice to evaluate the effectiveness, quality, and legitimacy of a given item or good.
Regulatory Consulting Ensure that each product or device complies with all FDA rules and regulations.
Study Budgeting Consulting Request for Consulting Services

Clinical Trials

Bioequivalence Studies Assess the expected biological equivalence of two proprietary preparations of a drug.
Case Report Monitoring & Auditing Ensure the adequate collection and traceability of clinical data in preparation for review by the FDA.
Clinical Research Services Determine the safety and effectiveness of medications and medical devices.
Clinical Trial Design Develop study-related protocols, case report forms (CRFs) and database tools for records management.
Comparator Drug Sourcing Streamline new drug development and clinical trials by comparing the efficacy of an experimental drug to a comparator drug.
Pharmacokinetic Studies Design a study that observes the time course of drug absorption, distribution, metabolism, and excretion, as means to test the safety and effective therapeutic management of drugs in an individual patient.

Show all 10 in Clinical Trials 4 more

Regulatory Affairs Consulting Receive assistance ensuring compliance with regulatory requirements.
Site Monitoring Maintain oversight over participant's health during a clinical trial.
Site Selection Select clinical trial sites with clinicians who recruit, enroll, treat and evaluate trial patients.
Study/Site Feasibility Study Explore and test study practicality.

Data Science/Bioinformatics

Biostatistical Design Use statistics to ensure appropriate pre-clinical and clinical study design.
In Silico ADME-PK Consultation Consult with experts for ADME-PK data analysis or predictive modelling design in different in vivo or in vitro states.
In Silico ADME-PK Predictions Use computer software to simulate in vivo physiological conditions of animals or humans to predict ADME-PK properties.
In Silico Cancer Genomics/Cancer Transcriptomics Analysis Interpret DNA sequencing and microarray data for cancer studies.
In Silico Protein Modification Analysis Use computational methods to predict the behavior of modified proteins.
In Silico Protein Sequence Analysis Use software to predict protein structural and functional features and secondary structure components.

Discovery Chemistry

Certified Standards Find certified standards for assays, tests and services.
Compound Synthesis Synthesize small molecule candidates for use in hit followup, lead optimization and medicinal chemistry.
Fragment Libraries Find fragment libraries for screening against a protein or cellular target.
Hit to Lead (H2L) Evaluate, perform limited optimization and identify small molecule hits from high throughput screens.
LCMS Analysis Physically separate substances using liquid chromatography and mass spectrometry.
Method Development and Validation Develop and validate methods for synthesis and scale up of drug candidates.

Show all 7 in Discovery Chemistry 1 more

Time of Flight Mass Cytometry (CyTOF™) Detect and quantify up to 34 different proteins simultaneously on a single-cell level.

Disease Models

Acute Liver Failure Models Measure therapeutic endpoints in animal models of acute liver failure.
Comparative Pharmacology Compare drug responses across species for improved reliability in translational studies.
Dermatology Models Measure therapeutic endpoints in animal models of dermatological disorders.
Inflammation Models Measure therapeutic endpoints in animal models for inflammation.
Inflammatory Bowel Disease Models Measure IBD symptom severity, cytokine levels and body weight, and evaluate IHC and Ariol images.
Liver Fibrosis Models Measure liver fibrosis using therapeutic endpoints such as collagen assessment, TUNEL staining and inflammatory markers.

Show all 8 in Disease Models 2 more

Osteoporosis Models Measure therapeutic endpoints in animal models of osteoporosis.
Stroke Models Measure therapeutic endpoints in animal models of stroke.

DNA & RNA

Capillary Electrophoresis Separate ng quantities of DNA to single base resolution.
siRNA Synthesis Produce high quality siRNAs for gene silencing studies.

Drug Development

Bioinformatics Consulting Consulting Services for the science of collecting and analyzing complex biological data
Large Molecule Drug Development Consulting Develop large molecule drugs and complex biologics that have a therapeutic effect.
Small Molecule Drug Development Consulting Request consulting services related to small molecule development.
Structural Chemistry Consulting Expert advice to evaluate the functions of specific chemicals based on their constructions and systems.
Target Validation Consulting Help to demonstrate that modification of target activity has potential therapeutic benefits.

Effectiveness

Bioequivalence Studies for Veterinary Drugs Assess the expected biological equivalence of two proprietary preparations of a veterinary drug.

General in vivo Toxicology

General Toxicology Use in vivo models to assess acute and sub-acute toxicity as well as chronic and sub-chronic toxicity.
Mammalian Toxicology Use toxicity testing models to carry out required FDA or REACH safety testing.

Human Biological Samples

Human Frozen Tissue For requesting frozen human tissue.

In Vitro ADME

Compound Distribution Determine the metabolic fate of a drug candidate in tissue and organs of diseased and normal animal models.
Conjugate Detection Measure the conjugation of endogenous small molecules to drug candidates after in vivo administration.
CYP Inhibition Assay Assess the inactivation and inhibition of cytochrome P450 (CYP450) in microsomes isolated from primary human hepatocytes or liver.
Drug Distribution Studies Determine the metabolic fate of compounds within tissues, organs and plasma.
Drug Drug Interactions Determine whether a substance affects the activity of a drug when both are administered together.
GI Fluid Stability Determine dosing and turnover of drug candidates in gastrointestinal fluids.

Show all 26 in In Vitro ADME 20 more

Intestinal Permeability Use Caco 2 and MCDK cells to assess mono-directional drug transport by passive diffusion in culture.
Membrane Transporters Use Caco 2 cells to assess bi-directional drug transport in the presence or absence of P-glycoprotein (P-gp) inhibitors.
Metabolic Stability Measure metabolic vulnerability to drug metabolizing enzymes using cell-free, cell-based and in vivo assays.
Metabolic Stability in Hepatocytes Assess the susceptibility of drugs to metabolism by Phase I (CYP450) and Phase II enzymes in liver cells.
Metabolic Stability in Microsomes Assess the susceptibility of drugs to metabolism by Phase I (CYP450) and Phase II enzymes in liver microsomes.
Metabolite Identification Identify drug metabolites that are formed after administration of drug to an animal model or patient.
Metabolite Identification and Profiling Estimate drug candidate metabolites after administration of drug to an animal or human subject.
Metabolite Quantification Quantify drug metabolites formed after drug administration to an animal model or patient.
Metabolite Structural Elucidation Use analytical tools to characterize metabolite structure.
Multidrug Resistance Identify potential causes of drug-drug interactions.
Nasal Permeability Test for passive diffusion and active transport in nasal permeability models.
No Label Methods Use mass spectrometry to detect and identify non-radiolabeled drug intermediates in pre-clinical samples.
Non Isotopic Labeling Track unlabeled macromolecules through a metabolic pathway or cell.
Ocular Permeability Measure passive diffusion and active transport of drugs across confluent ocular epithelial cells.
Plasma Stability Assay Determine degradation rate of drug candidates in plasma.
Protein Binding Ultrafiltration Measure the rate at which unbound drug passes through a dialysis membrane that models epithelial barrier pore size.
Reactive Metabolite Ensure that your drug candidate is not generating toxic reactive metabolites in vivo.
Red Blood Cell (RBC) Partitioning (Blood/Plasma Ratio) Measure the distribution of a compound between red blood cells and plasma.
Reference Standards Find reference standards for assays, tests and services.
Skin Permeability Use human skin models to determine transdermal delivery and percutaneous absorption of pre-clinical drugs.

In Vitro Assays

Apoptosis Assays Detect apoptotic events that lead to programmed cell death.
Cell Based Assays Apply compounds to cells and test for cellular phenotypes and effects on gene expression
Cell Based Assays Consulting Expert advice to evaluate the functions of specific chemicals based on their constructions and systems.
Glucose Uptake Measure glucose uptake in cultured cells using GLUT4 signaling assays.
In Vitro Assay Development Develop innovative assay and screening methods outside a living organism to enable a wide range of pre-clinical activities.

In Vitro Pharmacology

Dehydrogenase Assays Measure dehydrogenase activity in biochemical and cell-based assays.
G-Protein Coupled Receptor (GPCR) Assays Detect ligand binding, receptor dimerization and downstream signal transduction events.
In Vitro Oncology Models Use cell-based and biochemical models of cancer.
Kinase Assays Measure activity of over 500 kinases in biochemical or cell-based assays.
Oxidase Assays Use biochemical, cell-based or in vivo assays to measure oxidase activity.
Protease Assay Measure protease activity in biochemical and cell-based assays.

Show all 9 in In Vitro Pharmacology 3 more

Protein Kinase B (Akt) Assays Use biochemical, cell based or in vivo assays to measure Akt enzyme activity.
Selectivity Profiling Determine the specificity of a ligand for its target by testing it against a large panel of related target proteins.
Target Validation Demonstrate that modification of target activity has potential therapeutic benefits.

In Vitro Toxicology

ToxTracker assay An assay for detection of signaling pathways underlying carcinogenicity/genotoxicity.

In Vivo ADME

Chronic Bile Duct Cannulation (BDC) Study - Dog / Canine Conduct a bile duct cannulation (BDC) study in dogs/canines to support the absorption, distribution, metabolism and excretion profiling of your compound.
Chronic Bile Duct Cannulation (BDC) Study - Monkey / Non-human Primate Conduct a bile duct cannulation (BDC) study in monkeys/non-human primates to support the absorption, distribution, metabolism and excretion profiling of your compound.
Chronic Bile Duct Cannulation (BDC) Study - Other Species Conduct a bile duct cannulation (BDC) study in other species to support the absorption, distribution, metabolism and excretion profiling of your compound.
Chronic Bile Duct Cannulation (BDC) Study - Rat Conduct a bile duct cannulation (BDC) study in rats to support the absorption, distribution, metabolism and excretion profiling of your compound.
Expired Air Study - Mouse Conduct a study to collect expired air and monitor its radioactivity content in mice.
Expired Air Study - Other Species Conduct a study to collect expired air and monitor its radioactivity content in other species.

Show all 22 in In Vivo ADME 16 more

Expired Air Study - Rat Conduct a study to collect expired air and monitor its radioactivity content in rats.
Mass Balance Study - Dog / Canine Conduct a study to investigate the plasma pharmacokinetics and excretion of your compound as well as total radioactivity in dogs/canines.
Mass Balance Study - Monkey / Non-human Primate Conduct a study to investigate the plasma pharmacokinetics and excretion of your compound as well as total radioactivity in monkeys/non-human primates.
Mass Balance Study - Other Species Conduct a study to investigate the plasma pharmacokinetics and excretion of your compound as well as total radioactivity in other species.
Mass Balance Study - Rat Conduct a study to investigate the plasma pharmacokinetics and excretion of your compound as well as total radioactivity in rats.
Milk Secretion Study - Other Species Conduct a study to determine the extent of milk secretion of your radioactive compound in other species.
Milk Secretion Study - Rat Conduct a study to determine the extent of milk secretion of your radioactive compound in rats.
Ocular Distribution Study - Dog / Canine Conduct a study to determine the distribution of your compound in ocular tissues of the dog/canine.
Ocular Distribution Study - Monkey / Non-human Primate Conduct a study to determine the distribution of your compound in ocular tissues of the monkey/non-human primate.
Ocular Distribution Study - Other Species Conduct a study to determine the distribution of your compound in ocular tissues of other species.
Ocular Distribution Study - Rabbit Conduct a study to determine the distribution of your compound in ocular tissues of the rabbit.
Ocular Distribution Study - Rat Conduct a study to determine the distribution of your compound in ocular tissues of the rat.
Placental Transfer Study - Rabbit Conduct a study to determine the extent of placental transfer in rabbits by assessing the radioactivity of your compound in fetal tissue and maternal blood.
Placental Transfer Study - Rat Conduct a study to determine the extent of placental transfer in rats by assessing the radioactivity of your compound in fetal tissue and maternal blood.
Quantitative Whole Body Autoradiography (QWBA) - Non-rodent Species Conduct a study to determine the tissue distribution of your compound radiolabeled compound in non-rodent species.
Quantitative Whole Body Autoradiography (QWBA) - Rodent Species (Mouse, Rat) Conduct a study to determine the tissue distribution of your compound radiolabeled compound in rodent species.

In Vivo Pharmacokinetics

In Vivo Pharmacokinetics Run pharmacokinetic studies in animals that measure a drug's absorption, distribution, metabolism and excretion (ADME).
In Vivo PK Consulting Expert advice on pharmacokinetics and how specific drugs affect the body to determine function, effectiveness, dosage size, etc…
Mass Balance Elucidate excretory pathways and organ distribution of a parent drug and metabolites
Ocular Pharmacokinetic (PK) Screening - Dog / Canine Conduct a pharmacokinetic screening study in dogs/canines that measures the absorption, distribution, metabolism and excretion of your compound following ocular administration.
Ocular Pharmacokinetic (PK) Screening - Monkey / Non-human Primate Conduct a pharmacokinetic screening study in monkeys/non-human primates that measures the absorption, distribution, metabolism and excretion of your compound following ocular administration.
Ocular Pharmacokinetic (PK) Screening - Other Species Conduct a pharmacokinetic screening study in other species that measures the absorption, distribution, metabolism and excretion of your compound following ocular administration.

Show all 15 in In Vivo Pharmacokinetics 9 more

Ocular Pharmacokinetic (PK) Screening - Rabbit Conduct a pharmacokinetic screening study in rabbits that measures the absorption, distribution, metabolism and excretion of your compound following ocular administration.
Ocular Pharmacokinetic (PK) Screening - Rat Conduct a pharmacokinetic screening study in rats that measures the absorption, distribution, metabolism and excretion of your compound following ocular administration.
Pharmacokinetic (PK) Screening - Dog / Canine Run pharmacokinetic studies in dogs that measure a drug’s absorption, distribution, metabolism and excretion.
Pharmacokinetic (PK) Screening - Minipig Run pharmacokinetic studies in minipigs that measure a drug’s absorption, distribution, metabolism and excretion.
Pharmacokinetic (PK) Screening - Monkey / Non-human Primate Conduct a pharmacokinetic screening study in monkeys/non-human primates that measures the absorption, distribution, metabolism and excretion of your compound.
Pharmacokinetic (PK) Screening - Mouse Run pharmacokinetic studies in mice that measure a drug's absorption, distribution, metabolism and excretion.
Pharmacokinetic (PK) Screening - Other Species Run pharmacokinetic studies in large animals that measure a drug's absorption, distribution, metabolism and excretion.
Pharmacokinetic (PK) Screening - Rat Run pharmacokinetic studies in rats that measure a drug's absorption, distribution, metabolism and excretion.
Rat Efficacy Monotherapy Use rat models to determine the anti-cancer efficacy of a drug candidate compared to a positive control.

Market Access

Market Access Materials Find general strategies and methods used to market a pharmaceutical product or device.
Market Research & Business Intelligence Run market feasibility studies, establish customer needs, improve product performance and analyze competition.

Medical Communications

Medical Publications Make clear and accurate presentations of scientific and technical data.
Medical Writing and Editing/Manuscript Development Communicate scientific, technical and health-related information to a range of audiences.
Target Product Profile (TPP) A sponsor prepared document which summarizes the drug development program that is described in terms of the labelling concepts. This profile is a communication method used between the FDA and sponsor which can be used...

Model Development

Fresh Functional Human Tissue Vasodilation Assays Use fresh functional human tissue to assess vasodilation with various compounds.
In Silico PK-PD Modeling Quantitative modeling and simulations correlation of pharmacokinetic and pharmacodynamic endpoints in support of preclinical and clinical development.

Nanotechnology

Nanoparticle Conjugation and Functionalization Modify biomolecules to enhance structure and function.

Other Specialty Toxicology

Biosafety Testing Consulting Expert advice to conduct safe and responsible biological procedures and practices.

Pharmacovigilance

GxP Compliance Monitoring Ensure products or services adhere to a set minimum standard.

Protein Sciences

Affinity Tag Purification Purify proteins under physiological conditions at their native cellular levels.
Immunoprecipitation Precipitate a protein of interest out of solution using an antibody to which it binds.
Low Density Lipoprotein (LDL) Uptake Assay Investigate low density lipoprotein uptake and regulation at the cellular level.
Mass Spectrometry-Based Proteomics Detect histone post-translational modifications (hPTMs), histone variants, and interactomes at chromatin regions.
Peptide Array Use biologically active synthetic peptides arranged in a high density format to assess protein interaction.
Phosphorylation Analysis Identify phosphorylation sites in target proteins.

Show all 14 in Protein Sciences 8 more

Protein Identification Uncover or confirm the identity of a protein.
Protein Post-translational Modification Analysis Measure glycosylation, phosphorylation, sulfation, ubiquitination, methylation and acetylation.
Protein Products Find native and recombinant proteins and peptides.
Protein Purification Isolate native or recombinant proteins from a sample.
Protein Sequencing Determine the amino acid sequence of protein or peptide.
Protein Services Consulting Expert advice to evaluate and analyze protein function and expression.
Proteomics Do large-scale experimental analysis of proteins focused on understanding structure and function.
SILAC Enable incorporation of isotopic labels in proteins for mass spectrometry-based quantitative proteomics.

Radioanalysis

Stand-alone Radioanalysis of Animal Pre-clinical Samples Conduct analysis of radioactive samples from preclinical radiolabeled studies.

REACH Services

OECD 487: In Vitro Mammalian Cell Micronucleus Test Assess whether a test substance induces chromosomal changes in cultured cells.
REACH Services Assist in the registration, evaluation and authorization of chemical substances.

Safety Pharmacology

Safety Pharmacology Assess the impact of a therapeutic for human use on vital organ systems before first-in-man drug testing.

Scientific Data Services

Bioinformatics Bioinformatics is a powerful method of storing, retrieving and analyzing biological data.
Cancer Systems Biology Convert complex molecular data obtained from high-throughput technologies to deducible information.
Systems Pharmacology Understand how drugs interact with different molecular and cellular systems within biological models.

Target Animal and Human Food Safety

Toxicokinetic Analysis Determine the drug concentration at which off-target or toxic effects occur.

Testing Services

Membrane Permeability (PAMPA) Parallel Artificial Membrane Permeability Assay (PAMPA) - Measure passive diffusion of drugs by the parallel artificial membrane permeation assay.

Other services

IND Writing Receive assistance with materials for an IND application.
NDA Writing Receive assistance in the NDA application process.
Site Management Organizations Site Management Organization (SMO) is an organization that provides clinical trial related services to a contract research organization (CRO), a pharmaceutical company, a biotechnology company, a medical device...

United States Wake Forest, Wake forest 2 sites

Professional associations: American Society for Biochemistry and Molecular Biology (ASBMB), American Society for Pharmacology and Experimental Therapeutics (ASPET)
Website: www.integratedbioanalysis.com

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