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Pebble Biotechnology Laboratories

Pebble Biotechnology Laboratories is listed as a new startup research supplier in the Scientist.com network, with 2 sites in 1 country.

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Search companies, drugs, suppliers and investigators, and follow each one to the others. Individual plan, $249/seat/mo. Card required.

Sites 2

Countries 1

Type of company: New startup

Antibodies

Immunodetection Use antibodies to identify a protein or antigen.

Biomarkers

Anatomic Pathology Do macroscopic, microscopic, biochemical, immunologic and molecular examination of organs and tissues.
Biomarker Clinical Validation Evaluate the predictive ability of a candidate biomarker for a disorder.
Chemotaxis Assays Investigate the in vivo or in vitro movement of cells towards or away from a chemotactic agent.
Cytokine Release Assay Use in vivo or in vitro assays to detect unregulated or excessive release of pro-inflammatory cytokines.
In Vivo Apoptosis Detection Visualize and quantify apoptosis in real time.
Interferon Gamma Release Assay Use in vivo or in vitro assays to measure the cell-mediated immune response to an infectious agent.

Show all 9 in Biomarkers 3 more

Lipid Kinase Assays Use biochemical, cell-based or in vivo assays to measure lipid kinase activity.
Protein Bioanalysis Quantitative measurement of xenobiotics (drugs and their metabolites, and biological molecules in unnatural locations or concentrations) and Proteins in biological systems
Small Molecule Bioanalysis Detect and analyze the pharmacokinetic profile of small molecules.

Chemical and Compound Analysis

GLP Small Molecule Bioanalysis Detect and analyze the pharmacokinetic profile of small molecules.
Non GLP Small Molecule Bioanalysis Detect and analyze the pharmacokinetic profile of small molecules.
Phototoxicity & Photosensitization Test Test the potential for a product to elicit a reaction under UV exposure.

Clinical Trials

Bioequivalence Studies Assess the expected biological equivalence of two proprietary preparations of a drug.
Study/Site Feasibility Study Explore and test study practicality.

Show all 134 services 122 more

Disease Models

Acute Kidney Failure Models Measure therapeutic endpoints in animal models of acute kidney failure.
Acute Liver Failure Models Measure therapeutic endpoints in animal models of acute liver failure.
Acute Lung Injury Models Measure therapeutic endpoints in animal models of acute lung injury.
Artery On-A-Chip Platform Assess small blood vessels under near-in vivo conditions.
Atopic Dermatitis Models Measure therapeutic endpoints in animal models of atopic dermatitis.
Bacterial Infection Models Measure therapeutic endpoints in animal models of bacterial infection.

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Blood Models Test for therapeutic efficacy of drug candidates in blood disorder models.
Critical Care Models Diagnose and manage life-threatening conditions requiring sophisticated organ support and invasive monitoring.
Dermatology Models Measure therapeutic endpoints in animal models of dermatological disorders.
Drug-Induced Liver Injury (DILI) Toxicity Assays Use biochemical, cell-based or in vivo assays to measure toxicity from drug-induced liver injury.
General Pain Models Measure therapeutic endpoints in animal models of general pain.
In Vivo Technologies Models Carry out EEGs, cognition assessment, microdialysis, electrophysiology, MRI, ultrasound and tomographic analysis.
Infectious Disease Models Test therapeutic efficacy of drug candidate in infectious disease model.
Inflammation Models Measure therapeutic endpoints in animal models for inflammation.
Inflammatory Pain Models Measure therapeutic endpoints in animal models of inflammatory pain.
Irritant Models Measure therapeutic endpoints in animal models of skin irritation.
Ischemia Models Measure therapeutic endpoints in animal models of ischemia.
Kidney Transplant Models Measure therapeutic endpoints in kidney transplant models.
Liver Disease Animal Models Measure therapeutic endpoints in animal models with liver disease.
Liver Fibrosis Models Measure liver fibrosis using therapeutic endpoints such as collagen assessment, TUNEL staining and inflammatory markers.
LPS Acute Response Models Measure therapeutic endpoints in acute models of inflammation.
LPS Lung Inflammation Models Measure therapeutic endpoints in animal models of inflammation.
Receptor Binding Models Measure the binding and distribution of drugs and biologics in animal tissues.
Skin Graft Models Measure therapeutic endpoints in animal models of skin grafts.
Thrombosis Models Measure therapeutic endpoints in animal models of thrombosis.
Tissue Rejection Models Measure therapeutic endpoints in animal models of tissue rejection.
Wound Healing Models Measure therapeutic endpoints in animal models of wound healing.

DNA & RNA

DNA Extraction Extract DNA from an original source.

Drug Development

Pharmacology Consulting Request consulting services related to pharmacology and the chemical properties, biological effects, and therapeutic uses of drugs.
Safety Pharmacology Consulting Consulting services that help with the detection of potential undesirable pharmacodynamic effects of chemical entities on physiological functions.
Small Molecule Drug Development Consulting Request consulting services related to small molecule development.
Toxicology Consulting Use models to assess acute and sub-acute toxicity as well as chronic and sub-chronic toxicity.

Effectiveness

Antimicrobial Pharmacodynamics Ascertain the effectiveness of an antimicrobial compound and test levels of antibiotic resistance against specific bacterial pathogens.
Bioequivalence Studies for Veterinary Drugs Assess the expected biological equivalence of two proprietary preparations of a veterinary drug.
Laboratory Dose Confirmation Studies Conduct in vivo studies to confirm the effectiveness of a selected drug dose in the lab.
Laboratory Dose Determination Studies Compare the effectiveness of three non-zero therapeutic concentrations for various durations to a non-medicated control group, and a non-medicated uninfected control group.

General in vivo Toxicology

Dose Range Finding Study - Other Species Conduct a study to determine the dose range of your compound in other species.
General Toxicology Use in vivo models to assess acute and sub-acute toxicity as well as chronic and sub-chronic toxicity.
IV Toxicology Test the toxicological effect of IV delivery of drug candidate.
Mammalian Toxicology Use toxicity testing models to carry out required FDA or REACH safety testing.
Repeat Dose Toxicity Study - Other Species Conduct a repeat dose study in other species to determine the toxicity and toxicokinetic behavior of your compound.

Human Biological Samples

Human Organs-On-Chips Use Organs-On-Chips for target identification and validation, target-based screening, and phenotypic screening.

In Vitro ADME

Compound Distribution Determine the metabolic fate of a drug candidate in tissue and organs of diseased and normal animal models.
Drug Distribution Studies Determine the metabolic fate of compounds within tissues, organs and plasma.
Drug Drug Interactions Determine whether a substance affects the activity of a drug when both are administered together.
Metabolic Stability Measure metabolic vulnerability to drug metabolizing enzymes using cell-free, cell-based and in vivo assays.
Metabolic Stability in Hepatocytes Assess the susceptibility of drugs to metabolism by Phase I (CYP450) and Phase II enzymes in liver cells.
Metabolite Identification Identify drug metabolites that are formed after administration of drug to an animal model or patient.

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Metabolite Identification and Profiling Estimate drug candidate metabolites after administration of drug to an animal or human subject.
Metabolite Quantification Quantify drug metabolites formed after drug administration to an animal model or patient.
Skin Permeability Use human skin models to determine transdermal delivery and percutaneous absorption of pre-clinical drugs.

In Vitro Assays

Assay Development Construct or create new assays or modify existing ones.
In Vitro Efficacy Test Use in vitro models to test the efficacy of your products.

In Vitro Pharmacology

Immuno-oncology Assays Use biochemical, cell based or in vivo assays to measure the activity of immuno-therapy targets.
In Vitro Disease Models Screen pre-clinical candidates without the use of live animals.
In Vitro Eye Models Measure cytokine production, cell viability, apoptosis and wound healing.
In Vitro Hemolysis Assay Evaluate the toxicity of a drug, metabolite or excipient by hemolytic release of hemoglobin in the plasma.
In Vitro Hepatotoxicity Assays Use in vitro assays to measure hepatoxicity-related activities.
In Vitro Hypoxia Models Use in vitro models to measure therapeutic endpoints associated with hypoxia.

Show all 7 in In Vitro Pharmacology 1 more

Vascular Endothelial Growth Factor (VEGF) Assays Use biochemical, cell based or in vivo assays to monitor competitive or non-competitive binding of VEGF ligand.

In Vitro Toxicology

Cytotoxicity Test for effects on cell viability and proliferation
Epidermal Cell Toxicity Measure toxicity by quantifying the number of live/dead cells, cell membrane integrity and glutathione (GSH) levels.
Perfused Heart Examine cardiac contractile strength (inotropic effects), heart rate (chronotropic effects) and vascular effects.

In Vivo ADME

Absorption studies Study the factors determning how efficiently a compound may enter the bloodstream.
Chronic Bile Duct Cannulation (BDC) Study - Other Species Conduct a bile duct cannulation (BDC) study in other species to support the absorption, distribution, metabolism and excretion profiling of your compound.
Mass Balance Study - Other Species Conduct a study to investigate the plasma pharmacokinetics and excretion of your compound as well as total radioactivity in other species.
Ocular Distribution Study - Other Species Conduct a study to determine the distribution of your compound in ocular tissues of other species.
Tissue Distribution Study the tissues in which a compound or its metabolites, accumulate.

In Vivo Pharmacokinetics

In Vivo Pharmacokinetics Run pharmacokinetic studies in animals that measure a drug's absorption, distribution, metabolism and excretion (ADME).
In Vivo PK Consulting Expert advice on pharmacokinetics and how specific drugs affect the body to determine function, effectiveness, dosage size, etc…
Mass Balance Elucidate excretory pathways and organ distribution of a parent drug and metabolites
Ocular Pharmacokinetic (PK) Screening - Other Species Conduct a pharmacokinetic screening study in other species that measures the absorption, distribution, metabolism and excretion of your compound following ocular administration.
Pharmacokinetic (PK) Screening Measure the absorption, distribution, metabolism and excretion of a compound.
Pharmacokinetic (PK) Screening - Other Species Run pharmacokinetic studies in large animals that measure a drug's absorption, distribution, metabolism and excretion.

Medical Communications

Pharmacodynamic/ Pharmacokinetic Reports Create Pharmacodynamic/ Pharmacokinetic reports to report to the appropriate regulatory bodies.
Toxicology Reports Create pre-clinical toxicology reports.

Model Development

Animal Model Development Create new systems for profiling pre-clinical therapeutics, devices, and surgical techniques.
Custom Model Development Develop a custom disease model.
Surgical Models Create new animal models using techniques such as vascular catherization, soft tissue procedures or device implants.

Non-Human Biospecimen

Pig / Minipig / Porcine Biofluids Acquire fresh or frozen biofluids including but not limited to whole blood, plasma, serum, CSF, milk, urine, feces, bile, semen, aqueous humor, vitreous humor, saliva, tears, etc.
Pig / Minipig / Porcine Cells Acquire fresh or frozen cells including but not limited to RBCs, WBCs, PBMCs, endothelial cells, T cells, fibroblasts, hepatocytes, splenocytes, etc.
Pig / Minipig / Porcine Tissues Acquire fresh or frozen tissues including but not limited to those from the central nervous system, endocrine system, gastrointestinal system, integumentary system, reproductive system, lymphatic system, etc.

Oncology Models

Animal Hypoxia Models Measure therapeutic endpoints in hypoxic animal models.

Other Specialty Toxicology

Cutaneous Phototoxicity Study - Other Species Conduct a study in other species to determine if a toxic response is elicited after the initial exposure to your compound and subsequent exposure to light.
Ocular Phototoxicity Study - Other Species Conduct a study to determine the extent to which your compound is capable of producing phototoxic side effects in ocular tissues of other species.
Phototoxicity Determine whether drug treatment causes light-activated toxic effects.

Pharmacology

In Vivo Pharmacology Study the effects of drug candidates in animal models

REACH Services

Ex Vivo REACH Assays Perform testing on cells or tissues cultured directly from a test organism
In Vitro REACH Services Perform skin or eye irriation tests, sensitivily and geneotoxicity tests
In Vitro Skin Sensitization Determine whether a drug or cosmetic product may cause dermal sensitization.
In Vivo REACH Services Performing testing when in vitro studies cannot be used to predict biological responses
OECD 402: Acute Dermal Toxicity This method provides information on health hazard likely to arise from short-term exposure to a test chemical by dermal route.
OECD 404: Acute Dermal Irritation/Corrosion This method provides information on health hazard likely to arise from exposure to liquid or solid test substance by dermal application.

Show all 8 in REACH Services 2 more

OECD 405: Acute Eye Irritation/Corrosion This method provides information on health hazard likely to arise from exposure to test substance (liquids, solids and aerosols) by application on the eye.
OECD 406: Skin Sensitisation This method provides information on health hazard likely to arise from exposure to test substance via intradermical injection and/or epidermical application.

Safety Pharmacology

Immunotoxicity Measure effects of drugs on immune function, allergic hypersensitization and autoimmune toxicity.
Off Target Effects Assess toxicities by body weight, clinical chemistry, hematology, urinalysis and terminal necropsy and pathology.
Safety Pharmacology Assess the impact of a therapeutic for human use on vital organ systems before first-in-man drug testing.
Target Safety Assessment Understand the role of your drug target and assess risks in normal physiology.

Specialty Dosing Routes

Intra-Articular Toxicology Conduct a study to determine the toxicity and toxicokinetic behavior of your compound when delivered directly to the joint.
Intracameral Implant Toxicity and/or Toxicokinetic Study - Other Species Conduct an intracameral implant toxicity study in other species to determine the toxicity and toxicokinetic behavior of your compound.
Intravitreal Toxicity and/or Toxicokinetic Study - Other Species Conduct an intravitreal ocular toxicity study in other species to determine the toxicity and toxicokinetic behavior of your compound.
Ophthalmologic Toxicology Measure toxicity by microscopy, vitrectomy, tonometry, electroretionography and corneal colorimetry.
Repeat Dose Intravenous Infusion Study - Other Species Conduct a repeat dose intravenous infusion study in other species to determine the toxicity and toxicokinetic behavior of your compound.
Single Dose Acute Intravenous Infusion Study - Other Species Conduct a single dose intravenous infusion study in other species to determine the toxicokinetic behavior of your compound.

Show all 7 in Specialty Dosing Routes 1 more

Topical Dermal Toxicity and/or Toxicokinetic Study - Other Species Conduct a dermal study to determine the toxicity and/or toxicokinetic behavior of your compound when applied topically to other species.

Target Animal and Human Food Safety

Target Animal Safety (TAS) Studies Evaluate potential harmful effects associated with the use of a new animal drug in a controlled setting.
Tolerance Studies Conduct tolerance studies on target animals of veterinary products.
Toxicity Test for Veterinary Drugs Use the drug at 10X the recommended dose for 3X the recommended duration to evaluate its safety.
Toxicokinetic Analysis Determine the drug concentration at which off-target or toxic effects occur.

Testing Services

Ex Vivo Eye Irritation Test (EVEIT) Use optical coherence tomography (OCT) to monitor full-thickness recovery of corneal tissue.
In Vitro Skin Models Measure skin model penetration and invasion, photosensitivity and toxicity.
In Vitro Toxicology Testing Non-animal testing employing US and international methodologies for determining irritation and other undesirable potentials.
Phototoxicity and Photosensitization Screening Screen a consumer healthcare product for irritancy and/or allergy potential following exposure to UV light.
Phototoxicology Phototoxicity testing identifies and evaluates the potential of chemical agents to induce toxicity upon subsequent exposure to light.
Skin Elasticity Testing Measure the skin's ability to resist pressure (firmness) and its ability to return to its original position pre- and post-treatment.

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Skin Lightening Product Test Measure qualitative and quantitative changes in skin pigmentation under the influence of the test sample.
Tolerance Test Under Dermatologic Control Evaluate the acceptability and skin tolerance of a cosmetic product.

Other services

Nerve-On-A-Chip Neurotoxicity Assay Employ the micro-engineered nerve-on-a-chip technology to predict neurological safety and efficacy early in the drug development pipeline.

Website: www.pebble.bio

United Kingdom Manchester 2 sites

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