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EnquBio

EnquBio is listed as a small business research supplier in the Scientist.com network, with 2 sites in 1 country.

Search companies, drugs, suppliers and investigators, and follow each one to the others. Individual plan, $249/seat/mo. Card required.

Sites 2

Countries 1

Type of company: Small business

Antibodies

Antibody based Assay Development Create specific and sensitive assays for the immunodetection of disease-specific target antigens.
Antibody Humanization Increase an antibody's similarity to a variant produced naturally in humans.

Biomarkers

Antioxidant Assays Use biochemical, cell-based or in vivo assays to measure total antioxidant capacity.
Biomarker Analytical Validation Assess and optimize the characteristics of a candidate biomarker to ensure reproducibility and consistency.
Biomarker Clinical Utility Evaluate the potential clinical applications of a candidate biomarker.
Biomarker Discovery Identify a biomarker associated with disease progression of disease, effectiveness of therapy or diagnosis of disease or condition.
Biomarker Services Evaluating normal/abnormal biological conditions and characteristics within the body
Cell Migration Assays Measure chemotaxis, haptotaxis, transmigration and wound-healing.

Show all 27 in Biomarkers 21 more

Cell Viability Measure changes in cell number, cell division, DNA content or a cell metabolism marker such as ATP levels.
Chemotaxis Assays Investigate the in vivo or in vitro movement of cells towards or away from a chemotactic agent.
Colony Forming Cell Assay Examine ability of hematopoietic stem cells to form colonies in vitro.
Complete Blood Count Set of medical laboratory tests that provide information about the cells in blood.
Customized Primary Cell Isolation Plan and execute the isolation of primary cells from a specific biosample.
Flow Cytometry Identify fluorescently-labeled cells or physically separate cells from a larger population using biomarkers.
HCS Assay Development Requesting services related to HCS assay development.
Human Primary Cell Isolation Isolate primary cells from various human tissues.
Immunoassays Create antibody-based assays for the identification and quantification of specific antigens.
Immunophenotyping Separate cell types based on their expression of biomarkers or based on their individual and unique expression patterns.
Immunostaining Use labeled antibodies to detect proteins or other antigens in cells or tissues.
Lipid Kinase Assays Use biochemical, cell-based or in vivo assays to measure lipid kinase activity.
Lipid Peroxidation Assay Use in vitro or in vivo assays to evaluate the effects of oxidative stress on lipid structure and function.
Multiplex Circulating miRNA Assay Profile miRNAs directly from just 10 μl of crude biofluid or 0.1 ng of purified RNA.
Pharmacodynamic Biomarkers Discovery Identify candidate biomarkers indicative of the therapeutic outcome of a drug-target interaction.
Platelet Function Testing Evaluate complete platelet function in vivo or in vitro.
Predictive Biomarkers Discovery Identify candidate biomarkers suggestive of a response to a treatment.
Single Cell Isolation Isolate single cells for subsequent single-cell analysis.
Small Molecule Bioanalysis Detect and analyze the pharmacokinetic profile of small molecules.
TUNEL Assay Detect in situ DNA fragmentation.
Wound Healing Assay Use cell-based assays to investigate cell proliferation, cell migration and wound closure.

Cell Culture and Characterization

3D Cell Culture Use a scaffold-based or scaffold-free format to grow three dimensional cell and tissue structures.
Gene-Edited iPSCs Disease Models Use gene-edited iPSCs to model human diseases.
In Vitro Hydrogel-Based Culture of PDXs Enable the extended laboratory culture of cancer PDXs and other primary cells in 3D.
Induced Pluripotent Stem (iPS) Cell Reprogramming Generate induced pluripotent stem cells from adult somatic cells.
Isogenic Knockout iPSC Lines Mimic loss of function of genes associated with various diseases and disorders.
Signaling Pathways Find proteins, assays and custom reagents for the analysis of cell signaling pathways.

Show all 7 in Cell Culture and Characterization 1 more

STR profiling of human and mouse cell lines STR profiling of human and mouse cell lines

Show all 113 services 99 more

Data Science/Bioinformatics

Discovery Compound Screening Analytics Screening of an entire compound library directly against the drug target or in a more complex assay.

Discovery Chemistry

Compound Management Buy, maintain and process compound libraries, natural product libraries and building blocks.
Compound Purchase Buy compounds, building blocks or compound libraries.
Lead Optimization Perform chemical structural changes to improve preclinical drug candidate.
Target-Focused Compound Libraries Find activity-based libraries directed towards a protein or cell signaling target.
Transporters Selectively screen for compounds with good permeability in the intestine, skin, or blood-brain barrier using drug transporter a...

Disease Models

Inflammation Models Measure therapeutic endpoints in animal models for inflammation.
Xenografts Evaluate drug candidate in tissue graft or organ transplant model.

DNA & RNA

Cloning/Subcloning Clone or Subclone nucleotide sequence or gene.
CRISPR Using advanced CRISPR technology, add or delete base pairs at a specifically targeted DNA loci.
ddPCR-Based Plasma Genotyping Perform noninvasive tumor genotyping.
DNA Extraction Extract DNA from an original source.
Genome Editing Use CRISPR, ZFN, TALEN or AAV gene targeting for targeted gene mutations and creation of transgenics.
Genotyping Examine a DNA sequence to identify specific genetic varients .

Show all 12 in DNA & RNA 6 more

Knockout/Knockin Cell Lines Develop Knockout/Knockin Cell Line.
Nucleic Acid Hybridization Use a nucleic acid probe to identify complementary sequences.
qPCR Analysis Measure the accumulation of PCR products in real time.
Quantitative RT PCR Use quantitative reverse transcription polymerase chain reaction to measure absolute and relative mRNA abundance.
RNA Sequencing Use Next Generation Sequencing techniques to Identify RNA transcripts, examine differential expression patterns and analyze splice variants.
RNA Services Whether you’re isolating total RNA for whole genome expression analysis by microarray or setting up high content screening by s...

Drug Development

Small Molecule Drug Development Consulting Request consulting services related to small molecule development.

General in vivo Toxicology

Dose Range Finding Study - Mouse Conduct a study to determine the dose range of your compound in mice.
Repeat Dose Toxicity Study - Mouse Conduct a repeat dose study in mice to determine the toxicity and toxicokinetic behavior of your compound.
Single Dose Acute Toxicity Study - Mouse Conduct a single dose study in Mice and Murines to determine the toxicokinetic behavior of your compound.
Single Maximum Tolerated Dose (MTD) Mouse Study Use mouse models to determine the MTD of a drug candidate by a single administration in a 7 day period.

Human Biological Samples

Human iPSC's For requesting human sourced induced pluripotent stem cells.

In Vitro ADME

Plasma Stability Assay Determine degradation rate of drug candidates in plasma.

In Vitro Assays

Assay Development Construct or create new assays or modify existing ones.
Cell Based Assays Apply compounds to cells and test for cellular phenotypes and effects on gene expression
Cell Proliferation Measure cell number, cell viability and cell division.
High Content Screening Analyze whole cells or components of cells with simultaneous readout of several parameters.
HTS Assay Development Develop assays to use in high throughput screening.
In Vitro Assay Development Develop innovative assay and screening methods outside a living organism to enable a wide range of pre-clinical activities.

Show all 8 in In Vitro Assays 2 more

In Vitro Efficacy Test Use in vitro models to test the efficacy of your products.
Phenotype Assays Measure effects of drug candidate on the morphology or function of cells and whole animals.

In Vitro Pharmacology

Cellular Thermal Shift Assay Use a novel biophysical assay for in situ drug target engagement and mechanistic biomarker studies.
Drug Target Assays Gain insight into the selectivity and mode-of-action of a compound's pharmacological targets.
G-Protein Coupled Receptor (GPCR) Assays Detect ligand binding, receptor dimerization and downstream signal transduction events.
Glucose Transporter Assays Use biochemical, cell-based or in vitro assays to measure glucose transporter activity.
High Throughput Screening Conduct millions of chemical, genetic or pharmacological tests in a short period of time.
Immuno-oncology Assays Use biochemical, cell based or in vivo assays to measure the activity of immuno-therapy targets.

Show all 13 in In Vitro Pharmacology 7 more

Nucleoside Transporter Assays Use biochemical, cell-based or in vivo assays to measure nucleoside transporter activity.
Polymerase Assays Measure polymerase activity in biochemical and cell-based assays.
Protease Assay Measure protease activity in biochemical and cell-based assays.
Selectivity Profiling Determine the specificity of a ligand for its target by testing it against a large panel of related target proteins.
Target Characterization Characterize potential drug targets during the drug discovery process.
Target Identification Identify the target(s) of a biologically active substance.
Target Validation Demonstrate that modification of target activity has potential therapeutic benefits.

In Vitro Toxicology

Cytotoxicity Test for effects on cell viability and proliferation
Hematopoietic Cell Toxicity Examine cytotoxic effects of pre-clinical compounds or biologics on adult stem cells.

In Vivo Pharmacokinetics

In Vivo Pharmacokinetics Run pharmacokinetic studies in animals that measure a drug's absorption, distribution, metabolism and excretion (ADME).
Integrated In Vivo Services Package Process an entire In Vivo Project including: Dose Formulation, PK Screening, ADME-Profiling, Toxicology, Safety Pharmacology, DART, IND Filing from our bundle of suppliers.
Maximum Tolerated Dose (MTD) Studies Determine Maximum Tolerated Dose (MTD) of a drug candidate in either a single or repetitive dosing study in a rodent (typically mouse or rat).
Mouse Efficacy Monotherapy Use mouse models to determine the anti-cancer efficacy of a drug candidate compared to a positive control.
Ocular Pharmacokinetic (PK) Screening - Rat Conduct a pharmacokinetic screening study in rats that measures the absorption, distribution, metabolism and excretion of your compound following ocular administration.
Pharmacokinetic (PK) Screening Measure the absorption, distribution, metabolism and excretion of a compound.

Show all 12 in In Vivo Pharmacokinetics 6 more

Pharmacokinetic (PK) Screening - Mouse Run pharmacokinetic studies in mice that measure a drug's absorption, distribution, metabolism and excretion.
Pharmacokinetic (PK) Screening - Rat Run pharmacokinetic studies in rats that measure a drug's absorption, distribution, metabolism and excretion.
Rat Efficacy Combination Use rat models to determine the anti-cancer efficacy and potential synergy of a drug candidate with a standard drug treatment.
Rat Efficacy Monotherapy Use rat models to determine the anti-cancer efficacy of a drug candidate compared to a positive control.
Repetitive Maximum Tolerated Dose (MTD) Mouse Study Use mouse models to determine the MTD of a drug candidate by repetitive administrations for 7 days.
Repetitive Maximum Tolerated Dose (MTD) Rat Study Use rat models to determine the MTD of a drug candidate by repetitive administrations for 7 days.

Model Development

PBMC Humanized Mice Study and evaluate compounds for infectious diseases and graft rejection.

Nanotechnology

Liposomes Create artificial spherical vesicles that can be used as a vehicle for administration of drugs.

Non-Human Biospecimen

Mouse Cells Acquire fresh or frozen cells including but not limited to RBCs, WBCs, PBMCs, endothelial cells, T cells, fibroblasts, hepatocytes, splenocytes, etc.
Mouse Tissues Acquire fresh or frozen tissues including but not limited to those from the central nervous system, endocrine system, gastrointestinal system, integumentary system, reproductive system, lymphatic system, etc.

Oncology Models

Renal Xenograft Measure therapeutic endpoints in renal models of cancer.
Xenograft Models Measure therapeutic endpoints in cancer models using tumor cells transplanted from a donor of a different species.

Protein Sciences

ELISA Detect the presence of antigens recognized by antibodies or find antibodies that recognize an antigen.
Enzymology Enzymology studies the biochemical activity, structure, and function of enzymes. Two key area of Enzymology are Cytochrome P450...
FRET/BRET Detect the location of proteins in living cells and their ability to interact with other proteins.
Western Blots Detect specific proteins in a sample of tissue homogenate or extract.

Safety Pharmacology

Off Target Effects Assess toxicities by body weight, clinical chemistry, hematology, urinalysis and terminal necropsy and pathology.

Specialty Dosing Routes

Repeat Dose Intranasal Study - Mouse Conduct a repeat dose intranasal study in mice to determine the toxicity and toxicokinetic behavior of your compound.
Single Dose Acute Intranasal Study - Mouse Conduct a single dose intranasal study in mice to determine the toxicokinetic behavior of your compound.

Testing Services

In Vitro Toxicology Testing Non-animal testing employing US and international methodologies for determining irritation and other undesirable potentials.
Membrane Permeability (PAMPA) Parallel Artificial Membrane Permeability Assay (PAMPA) - Measure passive diffusion of drugs by the parallel artificial membrane permeation assay.

Website: www.enqubio.com

United States San Diego 2 sites

Minority-owned

US small-business federal-contractor designation, self-certified in the U.S. federal System for Award Management (SAM.gov). Coverage is limited to matched U.S. small-business suppliers, so an absent designation is not evidence of its absence.

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