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Runtogen Inc.

Runtogen Inc. is listed as a small business research supplier in the Scientist.com network, with 1 site in 1 country.

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Type of company: Small business

Agricultural Sciences Research & Development

Gene Isolation and cloning Development of methods for isolation of gene(s) of interest.

Antibodies

Antibody Humanization Increase an antibody's similarity to a variant produced naturally in humans.
Antibody Isotype Switching Modify antibody isotypes from any species to any human IgG isotype.
Antibody Protein De Novo Sequencing Sequence antibody proteins using multiple enzyme digestion and high-resolution LC-MS/MS.
Antibody Sequencing Sequence cDNA encoding variable heavy (VH) and variable light (VL) domains of a hybridoma cell line.
Antibody-Dependent Cell-Mediated Cytotoxicity Request services related to cell-mediated immune defense.
Antibody-Drug Conjugation Improve therapeutic properties of an antibody or drug by joining them together.

Show all 18 in Antibodies 12 more

Custom Antibodies Design and produce polyclonal and monoclonal antibodies.
Hybridoma Sequencing/Antibody Sequencing Determine the sequences of monoclonal antibodies.
In Vitro Monoclonal Antibody Production Generate monoclonal antibodies in vitro using cultured antibody-secreting hybridoma cell lines.
Integrated Antibody Development Package-US Process an entire Antibody Development Pipeline Project including: Antigen Synthesis, Antibody Generation, Antibody Characterization, Antibody Modification, Antibody Purification, Antibody Products from our bundle...
Monoclonal/Polyclonal Antibody Development Develop a monoclonal and/or polyclonal antibody.
Phosphospecific Antibodies Create antibodies to detect phosphorylated protein targets.
Polyclonal Antibody Production Generate polyclonal antibodies in vivo using evolutionary distant animal species.
Polyclonal/Monoclonal Antibody Production Generate polyclonal or monoclonal antibodies in a range of animal species, over-express antibodies in cultured cells.
Rabbit Monoclonal Antibody Development Develop monoclonal antibodies using rabbit as the host animal.
Recombinant Antibody Production Request services related to antibody production services.
Single Chain Variable Fragment (scFv) Create an antigen-specific antibody derivative using a linker to join a heavy and a light variable chain.
Yeast Display Discover or optimize eukaryotic proteins and antibodies that contain post translational modifications

Bioimaging

Bioimaging Visualize biological process non-invasively in real time.

Biomarkers

Cell Migration Assays Measure chemotaxis, haptotaxis, transmigration and wound-healing.
Colony Forming Cell Assay Examine ability of hematopoietic stem cells to form colonies in vitro.
Customized Primary Cell Isolation Plan and execute the isolation of primary cells from a specific biosample.
Human Primary Cell Isolation Isolate primary cells from various human tissues.
Microbiome Services Examine the community of commensal, symbiotic, and pathogenic microorganisms that make up the microbiome.
Stem Cell Analysis Assess hematopoietic, neural and mesenchymal cell progenitor proliferation and differentiation.

Show all 158 services 144 more

Cell Culture and Characterization

Cell Culture Culture primary or immortalized cell lines.
Cell Line Authentication Verify the identity and purity of an experimental cell line or industrial culture.
Cell Line Characterization Track source history and characterize cell lines to establish identity, purity and stability.
Cell Line Construction Create new recombinant cell lines to exact specifications.
Cell Lines Purchase culture reagents, cell lines and cellular material of any species. Cell Lines typically refer to legacy immortalised cells, that can be cultured and passaged “indefinitely” Primary Cells are cells that have...
Cell Transfection Produce, package and optimize transfection of your siRNA or DNA construct.

Show all 19 in Cell Culture and Characterization 13 more

Custom 3D Microtissue Development Convert cell lines into highly functional 3D microtissues using scaffold-free self-assembly.
Custom htert immortalization Custom human telomerase immortalized primary cells
Gene-Edited iPSCs Disease Models Use gene-edited iPSCs to model human diseases.
In Vitro Hydrogel-Based Culture of PDXs Enable the extended laboratory culture of cancer PDXs and other primary cells in 3D.
Induced Pluripotent Stem (iPS) Cell Reprogramming Generate induced pluripotent stem cells from adult somatic cells.
Isogenic Knockout iPSC Lines Mimic loss of function of genes associated with various diseases and disorders.
Recombinant Technology Manipulate genotypes to introduce or modify the expression of specific cell products or physical traits.
RNA-Based Transfection Deliver RNA to cells by microinjection, electroporation or lipid-mediated transfection.
Signaling Pathways Find proteins, assays and custom reagents for the analysis of cell signaling pathways.
Stem Cell Differentiation Acquire specialized cells from differentiated stem cells.
Stem Cell Methodologies Study Stem Cell characteristics.
STR profiling of human and mouse cell lines STR profiling of human and mouse cell lines
Viral Mediated Gene Delivery Use viral carriers to introduce new genetic material into a cell.

Chemistry, Manufacturing and Controls (CMC)

Bi-specific Antibodies Create a protein made of fragments of two monoclonal antibodies that bind to different antigens.
Integrated Antibody Development Package-Europe Process an entire Antibody Development Pipeline Project including: Antigen Synthesis, Antibody Generation, Antibody Characterization, Antibody Modification, Antibody Purification, Antibody Products from our bundle...

Clinical Consulting

Cell Services Consulting Whether you are an experienced drug hunter working in the pharmaceutical industry or an academic researcher looking to submit g...

Disease Models

Hematopoiesis Models Measure therapeutic endpoints in animal models of hematopoiesis.
Xenografts Evaluate drug candidate in tissue graft or organ transplant model.

DNA & RNA

Cell Free DNA Assay Detect known mutations and discover new ones in cell-free plasma DNA.
Cloning/Subcloning Clone or Subclone nucleotide sequence or gene.
CRISPR Using advanced CRISPR technology, add or delete base pairs at a specifically targeted DNA loci.
DNA Synthesis Produce DNA fragments for microarrays, PCR, cloning and expression studies.
Gene/Oligo Synthesis Synthesize oligonucleotide or gene for microarrays, RT-PCR and PCR cloning.
Genome Editing Use CRISPR, ZFN, TALEN or AAV gene targeting for targeted gene mutations and creation of transgenics.

Show all 13 in DNA & RNA 7 more

Knockout/Knockin Cell Lines Develop Knockout/Knockin Cell Line.
Multiplex Cellular miRNA Assay Use Firefly™ technology for multiplex cellular microRNA profiling.
RNA Interference Use small sequences of RNA that correspond to the targeted gene product to inhibit mRNA translation.
RNAi Pathway Analysis Use high-throughput RNAi genetic screens to elucidate relevant signaling pathways.
Sanger Sequencing Sequence single strand DNA fragments using DNA Polymerase.
shRNA Synthesis Design shRNA constructs that produce stable knockdown of the corresponding mRNA.
siRNA Synthesis Produce high quality siRNAs for gene silencing studies.

Drug Development

Assay Development Consulting Request consultant services measuring the activity of a drug or biochemical in an organism or organic sample.
Cellular Immunology Consulting Immunological activities of cells in experimental or clinical situations

Human Biological Samples

Cell Line and Cellular Services Promotion for Cells and Cell lines
HBS Alzheimer's Acquire fresh, frozen, or fixed Alzheimer's tissues or other related Alzheimer's HBS.
HBS Genetic Diseases For requesting Genetic Diseases HBS
HBS Parkinson's For requesting HBS Parkinson's
HBS: Human Biological Samples Request human biosamples including tissues, blood, serum, bone marrow, tissue microarrays, etc.
htert immortalized primary cells human telomerase immortalized primary cells

Show all 33 in Human Biological Samples 27 more

Human 3D cultures Provision of 3D culture of Human Primary Cells
Human Adult Stem Cells Acquire human stem cells isolated from various adult tissues.
Human Biofluids Acquire fresh/frozen biofluids based on patient demographics, disease stage, history and treatment.
Human Biopsy Cell Models Request human biopsy cell models.
Human Blood Acquire fresh/frozen human blood based on patient demographics, disease stage, history and treatment.
Human Bone Marrow Aspirates Acquire fresh/frozen Bone Marrow mononuclear cells based on patient demographics, disease stage, treatment and history.
Human Bone Marrow Cells Acquire fresh, frozen, or fixed normal bone marrow based on patient demographics and history.
Human Cell Lysates For requesting human Cell lysates.
Human Cell Products For requesting human cell by products like proteins, lysates, lysosomes etc
Human Endothelial Cells Endothelial cells are specialized epithelial cells that form a single layer lining the inner surface of all blood vessels and lymphatic vessels
Human Epithelial Cells Human epithelial cells are the most abundant cell type in the body and form the outer layer of skin and line various internal organs, including the digestive and respiratory tracts.
Human Fibroblasts Human Fibroblasts play a vital role in forming connective tissue
Human Hepatocytes Acquire human hepatocytes isolated from the liver.
Human HSC's For requesting human sourced hematopoetic stem cells
Human Immortalized Cell Culture For requesting human cells Cell Lines typically refer to legacy immortalised cells, that can be cultured and passaged “indefinitely” Primary Cells are cells that have been isolated from fresh tissue (or cultures) that...
Human iPSC's For requesting human sourced induced pluripotent stem cells.
Human Melanocytes Human Melanocytes are pigment-producing cells primarily found in the skin, hair follicles, and eyes
Human Microsomes Acquire microsomes derived from the endoplasmic reticulum of hepatic cells
Human MSC's For requesting human sourced mesenchymal stem cells.
Human Myoblasts Human Myoblasts are a type of immature white blood cell that forms in the bone marrow
Human Neural Stem Cells Acquire human neural stem cells isolated from brain tissue.
Human Organoids Test immuno-oncology drugs and therapies on fresh, unpropagated 3D tumor organoids to evaluate efficacy and understand drug mechanism of action. Understand the intact tumor immune microenvironment, cytotoxic efficacy...
Human Organs-On-Chips Use Organs-On-Chips for target identification and validation, target-based screening, and phenotypic screening.
Human Peripheral Blood Mononuclear Cells (PBMCs) Acquire fresh/frozen normal PBMCs based on patient demographics and history.
Human Primary Cells Acquire fresh/frozen human primary cells based on patient demographics, disease stage, history and treatment. Cell Lines typically refer to legacy immortalised cells, that can be cultured and passaged “indefinitely”...
Human Red Blood Cells Acquire fresh/frozen normal red blood cells based on patient demographics and history.
Tumor Cells Acquire tumor cells (either human or animal)

In Vitro ADME

Cell Fractionation Isolate organelles and subcellular components.
Cell Permeability and Absorbance Models Cell Permeability and Absorbance Model assay.
Membrane Transporters Use Caco 2 cells to assess bi-directional drug transport in the presence or absence of P-glycoprotein (P-gp) inhibitors.

In Vitro Assays

3Screen™ 3D In Vitro Services 3Screen™ Platform enables complete 3D cell culture characterization.
Assay Development Construct or create new assays or modify existing ones.
Cell Based Assays Apply compounds to cells and test for cellular phenotypes and effects on gene expression
Cell Based Assays Consulting Expert advice to evaluate the functions of specific chemicals based on their constructions and systems.
Cell Proliferation Measure cell number, cell viability and cell division.
Cell-based Screening Assays Apply compounds to cells and test for cellular phenotypes and effects on gene expression

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Hydroxyproline Assays Use biochemical, cell based or in vivo assays to quantify hydroxyproline or collagen in a sample.
In Vitro Efficacy Test Use in vitro models to test the efficacy of your products.
In Vitro Human Cell Assays Request in vitro human cells for assays

In Vitro Pharmacology

B-Cell Lymphoma 2 (BCL-2) Assays Use biochemical, cell based or in vivo assays to measure BCL-2 protein activity.
Drug Target Assays Gain insight into the selectivity and mode-of-action of a compound's pharmacological targets.
Extracellular signal Regulated Kinase Assays Use biochemical, cell based or in vivo assays to measure ERK enzyme activity.
Immuno-oncology Targets Develop drugs that take advantage of the immune system to target cancer cells.
Kinase Assays Measure activity of over 500 kinases in biochemical or cell-based assays.
Mitogen/Extracellular signal-regulated Kinase (MEK) Assays Use biochemical, cell based or in vivo assays to measure MEK enzyme activity.

Show all 8 in In Vitro Pharmacology 2 more

Programmed Cell Death-1 (PD-1) Assays Use biochemical, cell based or in vivo assays to measure PD-1 receptor activity.
Protein/Enzyme Targets For requesting Protein/Enzyme Targets

In Vitro Toxicology

ADCC and CDC Assay Services Measure toxicity of antibodies.
Endothelial Cell Toxicity Assess the cytotoxic effects of pre-clinical compounds on the vascular system.
Epidermal Cell Toxicity Measure toxicity by quantifying the number of live/dead cells, cell membrane integrity and glutathione (GSH) levels.
HepaRG Cells Obtain terminally differentiated and cryopreserved hepatic cells that retain many characteristics of primary human hepatocytes.

Model Development

PBMC Humanized Mice Study and evaluate compounds for infectious diseases and graft rejection.

Non-Human Biospecimen

Dog / Canine Cells Acquire fresh or frozen cells including but not limited to RBCs, WBCs, PBMCs, endothelial cells, T cells, fibroblasts, hepatocytes, splenocytes, etc.
Goat Cells, Tissues, and Biofluids Acquire fresh or frozen cells, tissues, and biofluids including but not limited to whole blood, PBMCs, tissue slides, etc.
Guinea Pig Cells Acquire fresh or frozen cells including but not limited to RBCs, WBCs, PBMCs, endothelial cells, T cells, fibroblasts, hepatocytes, splenocytes, etc.
Llama Cells, Tissues, and Biofluids Acquire fresh or frozen cells, tissues, and biofluids including but not limited to whole blood, PBMCs, tissue slides, etc.
Monkey / Non-Human Primate / NHP Cells Acquire fresh or frozen cells including but not limited to RBCs, WBCs, PBMCs, endothelial cells, T cells, fibroblasts, hepatocytes, splenocytes, etc.
Mouse Cells Acquire fresh or frozen cells including but not limited to RBCs, WBCs, PBMCs, endothelial cells, T cells, fibroblasts, hepatocytes, splenocytes, etc.

Show all 11 in Non-Human Biospecimen 5 more

Pig / Minipig / Porcine Cells Acquire fresh or frozen cells including but not limited to RBCs, WBCs, PBMCs, endothelial cells, T cells, fibroblasts, hepatocytes, splenocytes, etc.
Rabbit Cells Acquire fresh or frozen cells including but not limited to RBCs, WBCs, PBMCs, endothelial cells, T cells, fibroblasts, hepatocytes, splenocytes, etc.
Rat Cells Acquire fresh or frozen cells including but not limited to RBCs, WBCs, PBMCs, endothelial cells, T cells, fibroblasts, hepatocytes, splenocytes, etc.
Xenopus Cells, Tissues, and Biofluids Acquire fresh or frozen cells, tissues, and biofluids including but not limited to whole blood, PBMCs, tissue slides, oocytes, etc.
Zebrafish Cells, Tissues, and Biofluids Acquire fresh or frozen cells, tissues, and biofluids including but not limited to whole blood, PBMCs, tissue slides, sperm, etc.

Oncology Models

3D Triculture Breast Cancer Model Use tricultures of breast cancer cell lines, hMSCs, and endothelial tubules for evaluating breast cancer progression.
Murine Adenocarcinoma 16 (MAC16) Murine Test for therapeutic efficacy of drug candidates in muscle wasting models.
NCG Model Study tumor biology and immuno-oncology in the CRISPR/Cas9-generated immunodeficient mouse model.
Oral Xenograft Measure therapeutic endpoints in oral cancer models as well as cancer models related to the Pharynx.
Ovarian Cancer Mouse Measure therapeutic endpoints in animal models of ovarian cancer.
T11 (Breast Cancer) Measure therapeutic endpoints in animal models of breast cancer.

Product Orders

Kits and Reagents Submit a request to multiple vendors for kits and reagents.

Protein Sciences

Cytokines Find recombinant cytokines or cytokine assays.
Fusion Proteins Use recombinant DNA technology to create and express proteins derived from more than one gene.
Insect Expression Use baculovirus infected cells or non-lytic cell systems to produce glycosylated proteins.
Large Scale Protein Production Produce large amounts of protein using fermentors, wave mixers, bioreactors, and large-scale purification workflows.
Lentivirus Production Develop lentiviruses and production protocols.
Mammalian Expression Express high yields of recombinant proteins, antibodies, virus, viral-subunit proteins and gene-therapy vectors.

Show all 13 in Protein Sciences 7 more

Peptide/Protein Products Purchase off-the-shelf protein or peptide products.
Phage Display Use in vitro screening method to identify protein binding partners.
Protein Production Produce recombinant protein molecules in prokaryotic or eukaryotic systems.
Protein Products Find native and recombinant proteins and peptides.
Recombinant Proteins Use recombinant DNA to produce proteins in vivo or in vitro.
Virus Production Produce high titer viruses, viral expression vectors and vaccines.
Yeast Expression Amplify eukaryotic proteins that contain post translational modifications.

REACH Services

In Vivo REACH Services Performing testing when in vitro studies cannot be used to predict biological responses
OECD 432: In Vitro 3T3 NRU Phototoxicity Test Test the cytotoxic effects of chemical substances and environmental samples on cell membranes.

Safety Pharmacology

Off Target Effects Assess toxicities by body weight, clinical chemistry, hematology, urinalysis and terminal necropsy and pathology.

Testing Services

OECD 442E: Human Cell Line Activation Test (h-CLAT) In vitro skin sensitization test to predict skin sensitization potency.

Website: www.runtogen.com

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