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Research supplier
Dermal Technology Laboratory
Dermal Technology Laboratory is listed as a small business research supplier in the Scientist.com network, with 1 site in 1 country.
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Services
What this research supplier says it provides, as listed in the Scientist.com network.
Type of company: Small business
Clinical Consulting
- Product Testing Consulting Expert advice to evaluate the effectiveness, quality, and legitimacy of a given item or good.
In Vitro ADME
- Ocular Permeability Measure passive diffusion and active transport of drugs across confluent ocular epithelial cells.
- Skin Permeability Use human skin models to determine transdermal delivery and percutaneous absorption of pre-clinical drugs.
In Vitro Assays
- In Vitro Efficacy Test Use in vitro models to test the efficacy of your products.
In Vitro Pharmacology
- In Vitro Disease Models Screen pre-clinical candidates without the use of live animals.
Product Development
- Personal/Consumer Care Product or Service Request relating to the creation, testing or manufacturing of a personal care/consumer health/cosmetic product, ingredient or raw material.
REACH Services
- In Vitro REACH Services Perform skin or eye irriation tests, sensitivily and geneotoxicity tests
Specialty Dosing Routes
- Dermal Toxicology Assess toxicity in rodent dermal testing models.
Testing Services
- ASTM E1207: Antiperspirant Clinical Testing Determine antiperspirant efficacy for products (e.g. deodorant) that are intended to be applied to the underarm.
- Characteristic Testing Characterization of physical and chemical properties of raw materials
- Consumer Care Testing and Substantiation Test personal care products using analytical, in vitro, and microbial test services
- Human Repeat Insult Patch Test (HRIPT) Examples of which include Topical Irritation, Allergenicity, Phototoxicity and Photoallergy testing.
- In Vitro Claim Substantiation Evaluation using FDA Broad Spectrum and/ or ISO 24443
- In Vitro Skin Models Measure skin model penetration and invasion, photosensitivity and toxicity.
Show all 18 in Testing Services
- In Vitro Toxicology Testing Non-animal testing employing US and international methodologies for determining irritation and other undesirable potentials.
- ISO 16217: Water Resistant Testing Evaluation of sunscreen's water resistance (40 and 80 minute)
- Ocular Corrosion Testing Use in vitro models to determine whether a product (or ingredient) can cause ocular corrosion.
- Ocular Irritation Test Use human subjects to determine whether a cosmetic product or ingredient can cause ocular irritation.
- OECD 435: Skin Corrosion Test - Membrane Barrier Method Use in vitro models to determine whether a cosmetic product or ingredient can cause skin corrosion.
- OECD 442C: Direct Peptide Reactivity Assay (DPRA) Determine whether a test article satisfies the protein-binding criterion for skin sensitizers.
- OECD 442D: ARE-Nrf2 Luciferase Test An in vitro test method (KeratinoSensTM and/or LuSens) that models the second key event in the Adverse Outcome Pathway for Dermal Sensitization.
- OECD 442E: Human Cell Line Activation Test (h-CLAT) In vitro skin sensitization test to predict skin sensitization potency.
- Safety In-Use Studies Safety-in-use studies assess the potential for a product to elicit adverse reactions under normal use conditions.
- Sebum Production Testing to evaluate the oil production in the skin
- Trans-Epidermal Water Loss (TEWL) Use a sensing electrode encased in a chimney to measure the relative humidity percentage at the skin surface.
- Viscoelasticity Evaluation when applying a sinusoidal force, calculating the resulting strain response and determining the elastic-spring-like storage modulus and the flow-like loss modulus.
Where it operates
Sites by country, with the cities in each.
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United Kingdom 1 site
About this supplier
In the supplier's own words, as listed in the Scientist.com network.
Dermal Technology Laboratory specialises in in vitro dermal absorption studies that are required as part of the safety testing of new and existing chemicals, agrochemicals, personal care, and pharmaceutical products. DTL is uniquely placed as the world’s only facility solely dedicated to the conduct of GLP compliant in vitro percutaneous absorption. Our speciality scientists have established international reputations as leaders in the field; this includes integral development of in vitro guidelines (including OECD 428). They can provide advice on all aspects of percutaneous absorption...
Show the full description
Dermal Technology Laboratory specialises in in vitro dermal absorption studies that are required as part of the safety testing of new and existing chemicals, agrochemicals, personal care, and pharmaceutical products.
DTL is uniquely placed as the world’s only facility solely dedicated to the conduct of GLP compliant in vitro percutaneous absorption. Our speciality scientists have established international reputations as leaders in the field; this includes integral development of in vitro guidelines (including OECD 428). They can provide advice on all aspects of percutaneous absorption comprising study review and guideline interpretation.
Our in vitro dermal absorption studies routinely utilize human, rat and pig skin. We provide radiochemical formulation preparation and analysis or cold analytical techniques including HPLC and GC as appropriate. We also offer ICP-Optical Emission Spectroscopy (ICP-OES).
In addition to safety assessment studies, the company is involved with the research and development of new products aimed at improving the delivery of drugs into and through the skin using novel formulation technology. Utilizing high throughput, cost-effective, fast delivery screen for product selection and formulation optimization
DTL offer a consultancy service in the area of dermal absorption, including preparation of bridging cases, design and interpretation of percutaneous absorption studies for submission to various Regulatory authorities, including EFSA and SCCS in the European Union and EPA/FDA in the USA.
- Website
- www.dermaltechnology.com
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