Sanford Burnham Medical Research Institute - Protein Analysis Core

The Protein Analysis Core provides a variety of analytical services focused on biophysical characterization of structural and functional properties of proteins in solution, under native, non-denaturing conditions. We perform quality control of protein samples (folding, stability, aggregation); measure molecular weight of proteins, protein complexes, oligomers and assemblies; characterize protein conformation and shape in solution; determine oligomeric state of protein (including stoichiometry and Kd for self-association) and measure protein binding to proteins, peptides, small molecules, compounds, metals, nucleotides and other ligands (including determination of equilibrium (Kd) and kinetic rate (kon, koff) constants, stoichiometry, binding enthalpy and entropy).