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TheWell Bioscience

TheWell Bioscience is listed as a small business research supplier in the Scientist.com network, with 2 sites in 1 country.

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Search companies, drugs, suppliers and investigators, and follow each one to the others. Individual plan, $249/seat/mo. Card required.

Sites 2

Countries 1

Type of company: Small business

Antibodies

Antibody-Dependent Cell-Mediated Cytotoxicity Request services related to cell-mediated immune defense.
In Vitro Monoclonal Antibody Production Generate monoclonal antibodies in vitro using cultured antibody-secreting hybridoma cell lines.

Bioimaging

Bioimaging Visualize biological process non-invasively in real time.
Microscopy Use microscopy to analyze surfaces of biological materials and to develop 3D images of biological structures.

Biomarkers

Bone Resorption Assay Functionally analyze osteoclast activity in vitro.
Cell Membrane Lipidomics Study the pathways and networks of membrane lipids.
Cell Migration Assays Measure chemotaxis, haptotaxis, transmigration and wound-healing.
Cell Viability Measure changes in cell number, cell division, DNA content or a cell metabolism marker such as ATP levels.
Colony Forming Cell Assay Examine ability of hematopoietic stem cells to form colonies in vitro.
Customized Primary Cell Isolation Plan and execute the isolation of primary cells from a specific biosample.

Show all 13 in Biomarkers 7 more

Cytokine Release Assay Use in vivo or in vitro assays to detect unregulated or excessive release of pro-inflammatory cytokines.
Human Primary Cell Isolation Isolate primary cells from various human tissues.
Islet Cell Autoantibodies (ICA) Testing Detect Type 1 diabetes-related autoantibodies.
Paraffin-based Histology Perform sectioning and histological analysis of wax-embedded samples.
Single Cell Isolation Isolate single cells for subsequent single-cell analysis.
Stem Cell Analysis Assess hematopoietic, neural and mesenchymal cell progenitor proliferation and differentiation.
T Cell Epitope Characterization Evaluate the potency and immunodominance of T-cell epitopes within a molecule.

Cell Culture and Characterization

3D Cell Culture Use a scaffold-based or scaffold-free format to grow three dimensional cell and tissue structures.
Adherent Cell Culture Grow monolayers of anchorage-dependent cells.
Bacterial Cell Culture Culture and Grow bacterial cells.
Cell and Tissue Histology Prepare and stain frozen, fixed and embedded (FFPE) tissue samples.
Cell Culture Culture primary or immortalized cell lines.
Cell Line Characterization Track source history and characterize cell lines to establish identity, purity and stability.

Show all 24 in Cell Culture and Characterization 18 more

Cell Line Construction Create new recombinant cell lines to exact specifications.
Cell Lines Purchase culture reagents, cell lines and cellular material of any species. Cell Lines typically refer to legacy immortalised cells, that can be cultured and passaged “indefinitely” Primary Cells are cells that have...
Cell Sorting The purpose of cell separation is to isolate a cell population from other cells in a biological sample.
Cell Transfection Produce, package and optimize transfection of your siRNA or DNA construct.
Custom 3D Microtissue Development Convert cell lines into highly functional 3D microtissues using scaffold-free self-assembly.
Explant Culture Culture cells obtained from a part or parts of an in vivo structure.
H & E Services For requesting services related to H&E Services
Histology Examine by microscopy the anatomy of cells and tissues of clinical patients and animal models.
In Vitro Hydrogel-Based Culture of PDXs Enable the extended laboratory culture of cancer PDXs and other primary cells in 3D.
Induced Pluripotent Stem (iPS) Cell Reprogramming Generate induced pluripotent stem cells from adult somatic cells.
Insect Tissue Culture Grow insect cells.
Microphysiological system (MPS)/organoid analytics microTMA produced from fixed microtissues (MPS)
Microphysiological Systems/organoid transcriptomics Microphysiological Systems/organoid transcriptomics
Organotypic Culture Co-culture different cells to enable in vitro growth of an in vivo tissue or organ equivalent.
Recombinant Technology Manipulate genotypes to introduce or modify the expression of specific cell products or physical traits.
Single Cell Services Request services to perform genomics, transcriptomics, proteomics, metabolomics and cell–cell interactions at the single cell level
Stem Cell Differentiation Acquire specialized cells from differentiated stem cells.
Stem Cell Methodologies Study Stem Cell characteristics.

Show all 171 services 155 more

Chemical and Compound Analysis

Light Sheet Fluorescence Microscopy Use a planar sheet of light to section transparent tissues and generate a 3D image.
Scanning and Transmission Electron Microscopy Examine the fine structures of molecules, cells and tissues with sub-nanometer resolution.

Chemistry, Manufacturing and Controls (CMC)

Subcellular Fraction Test System Obtain human, minipig, mouse, or rat dermal microsomes as in-stock standard test systems for the development of safer topical and transdermal products.

Clinical Consulting

Cell Services Consulting Whether you are an experienced drug hunter working in the pharmaceutical industry or an academic researcher looking to submit g...

Discovery Chemistry

Pharmacophore Modeling Use computer models to identify hits based on structural similarity to known active compounds.

Disease Models

Cardiovascular Models Test the therapeutic efficacy of drug candidates in cardiovacular disease models.
Cartilage Repair Models Measure therapeutic endpoints in animal models of cartilage repair.
Inflammation Models Measure therapeutic endpoints in animal models for inflammation.
Object Recognition Measure spatial navigation, working memory and cognitive function in animal models.
Skin Graft Models Measure therapeutic endpoints in animal models of skin grafts.
Tissue Rejection Models Measure therapeutic endpoints in animal models of tissue rejection.

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Xenografts Evaluate drug candidate in tissue graft or organ transplant model.

DNA & RNA

Knockout/Knockin Cell Lines Develop Knockout/Knockin Cell Line.
Multiplex Cellular miRNA Assay Use Firefly™ technology for multiplex cellular microRNA profiling.
Tissue Microarray Screen large numbers of tissues for the presence or absence of specific molecular markers.

Drug Development

Assay Development Consulting Request consultant services measuring the activity of a drug or biochemical in an organism or organic sample.
Cellular Immunology Consulting Immunological activities of cells in experimental or clinical situations

General in vivo Toxicology

Mammalian Toxicology Use toxicity testing models to carry out required FDA or REACH safety testing.

Human Biological Samples

3D InSight™ Liver Microtissues Perform in vitro assessment of islet function for efficacy and toxicity testing.
Cell Line and Cellular Services Promotion for Cells and Cell lines
Custom PDX models For requesting Custom PDX models
Existing PDX models For requesting Existing PDX models
HBS Diabetes For requesting HBS Diabetes.
HBS: Human Biological Samples Request human biosamples including tissues, blood, serum, bone marrow, tissue microarrays, etc.

Show all 30 in Human Biological Samples 24 more

Human 3D cultures Provision of 3D culture of Human Primary Cells
Human Adult Stem Cells Acquire human stem cells isolated from various adult tissues.
Human Biopsy Cell Models Request human biopsy cell models.
Human Bone Marrow Aspirates Acquire fresh/frozen Bone Marrow mononuclear cells based on patient demographics, disease stage, treatment and history.
Human Bone Marrow Cells Acquire fresh, frozen, or fixed normal bone marrow based on patient demographics and history.
Human Cell Lysates For requesting human Cell lysates.
Human Cell Products For requesting human cell by products like proteins, lysates, lysosomes etc
Human Endothelial Cells Endothelial cells are specialized epithelial cells that form a single layer lining the inner surface of all blood vessels and lymphatic vessels
Human Epithelial Cells Human epithelial cells are the most abundant cell type in the body and form the outer layer of skin and line various internal organs, including the digestive and respiratory tracts.
Human Exosomes Request services related to the creation and development of human exosomes
Human Fibroblasts Human Fibroblasts play a vital role in forming connective tissue
Human HSC's For requesting human sourced hematopoetic stem cells
Human Immortalized Cell Culture For requesting human cells Cell Lines typically refer to legacy immortalised cells, that can be cultured and passaged “indefinitely” Primary Cells are cells that have been isolated from fresh tissue (or cultures) that...
Human iPSC's For requesting human sourced induced pluripotent stem cells.
Human Microsomes Acquire microsomes derived from the endoplasmic reticulum of hepatic cells
Human MSC's For requesting human sourced mesenchymal stem cells.
Human Myoblasts Human Myoblasts are a type of immature white blood cell that forms in the bone marrow
Human Neural Stem Cells Acquire human neural stem cells isolated from brain tissue.
Human Organoids Test immuno-oncology drugs and therapies on fresh, unpropagated 3D tumor organoids to evaluate efficacy and understand drug mechanism of action. Understand the intact tumor immune microenvironment, cytotoxic efficacy...
Human Organs-On-Chips Use Organs-On-Chips for target identification and validation, target-based screening, and phenotypic screening.
Human Peripheral Blood Mononuclear Cells (PBMCs) Acquire fresh/frozen normal PBMCs based on patient demographics and history.
Human Primary Cells Acquire fresh/frozen human primary cells based on patient demographics, disease stage, history and treatment. Cell Lines typically refer to legacy immortalised cells, that can be cultured and passaged “indefinitely”...
Human Red Blood Cells Acquire fresh/frozen normal red blood cells based on patient demographics and history.
Tumor Cells Acquire tumor cells (either human or animal)

In Vitro ADME

Blood Brain Barrier Measure movement of drugs from circulating blood to brain extracellular fluid.
Cell Fractionation Isolate organelles and subcellular components.
Cell Permeability and Absorbance Models Cell Permeability and Absorbance Model assay.
Human Blood Brain Barrier on a Chip (BBBoC) Create a blood–brain barrier multicellular model to test drug delivery to the brain.
Intestinal Permeability Use Caco 2 and MCDK cells to assess mono-directional drug transport by passive diffusion in culture.
Metabolic Stability in Hepatocytes Assess the susceptibility of drugs to metabolism by Phase I (CYP450) and Phase II enzymes in liver cells.

Show all 10 in In Vitro ADME 4 more

Metabolite Identification and Profiling Estimate drug candidate metabolites after administration of drug to an animal or human subject.
Nasal Permeability Test for passive diffusion and active transport in nasal permeability models.
Red Blood Cell (RBC) Partitioning (Blood/Plasma Ratio) Measure the distribution of a compound between red blood cells and plasma.
Skin Permeability Use human skin models to determine transdermal delivery and percutaneous absorption of pre-clinical drugs.

In Vitro Assays

3D Cell Microscopy Assay Investigate cellular and subcellular events in three dimensional 3D cultures by using fluorescence microscopy.
3Screen™ 3D In Vitro Services 3Screen™ Platform enables complete 3D cell culture characterization.
Apoptosis Assays Detect apoptotic events that lead to programmed cell death.
Apoptotic Cell Staining Detect apoptotic cells in culture.
Assay Development Construct or create new assays or modify existing ones.
Caspase Assay Detect early to mid stage apoptosis or differentiate apoptosis from necrosis.

Show all 22 in In Vitro Assays 16 more

Cell Based Assays Apply compounds to cells and test for cellular phenotypes and effects on gene expression
Cell Based Assays Consulting Expert advice to evaluate the functions of specific chemicals based on their constructions and systems.
Cell Cycle Assays Measure cell cycle markers and the molecular events that control cell cycle progression.
Cell Proliferation Measure cell number, cell viability and cell division.
Cell-based Screening Assays Apply compounds to cells and test for cellular phenotypes and effects on gene expression
Epigenetic Profiling In Vitro Assays Test for epigenetic modifications and indicator levels via in vitro assays.
Glucose Release Assay Determine free glucose levels in biological samples.
Glucose Uptake Measure glucose uptake in cultured cells using GLUT4 signaling assays.
High Content Screening Analyze whole cells or components of cells with simultaneous readout of several parameters.
Hydroxyproline Assays Use biochemical, cell based or in vivo assays to quantify hydroxyproline or collagen in a sample.
In Vitro Efficacy Test Use in vitro models to test the efficacy of your products.
In Vitro Human Cell Assays Request in vitro human cells for assays
Invasion Assays Monitor and quantify the ability of cultured cells to permeate real or artificial biological barriers.
Organoid Screening Assay Evaluate the effects of various substances, such as drugs or genetic modifications, on organoids.
Serine Protease Assay Detect apoptosis by measuring protease activity.
Stem Cell Differentiation Microscopy Assay› Elucidate mechanisms of stem cell renewal and differentiation in vitro using fluorescence microscopy.

In Vitro Pharmacology

B-Cell Lymphoma 2 (BCL-2) Assays Use biochemical, cell based or in vivo assays to measure BCL-2 protein activity.
Drug Target Assays Gain insight into the selectivity and mode-of-action of a compound's pharmacological targets.
High Throughput Screening Conduct millions of chemical, genetic or pharmacological tests in a short period of time.
In Vitro Bone Models Measure osteoclast activity and bone formation in human or rat osteoclasts.
In Vitro Cardiovascular Models Measure stimulation and inhibition of lipolysis, adipogenesis and endothelial cell migration.
In Vitro Disease Models Screen pre-clinical candidates without the use of live animals.

Show all 9 in In Vitro Pharmacology 3 more

In Vitro Hypoxia Models Use in vitro models to measure therapeutic endpoints associated with hypoxia.
In Vitro Neural Models Use cultured neurons, neuronal progenitor cells and stem cell differentiation to create cellular models of neurological disease.
Programmed Cell Death-1 (PD-1) Assays Use biochemical, cell based or in vivo assays to measure PD-1 receptor activity.

In Vitro Toxicology

Cardiomyocyte Toxicity Assess cytotoxic effects of pre-clinical compounds on cardiomyocytes.
Cytotoxicity Test for effects on cell viability and proliferation
Cytotoxicity Testing Determine whether a cosmetic product or ingredient is toxic to in vitro cell cultures.
Endothelial Cell Toxicity Assess the cytotoxic effects of pre-clinical compounds on the vascular system.
Epidermal Cell Toxicity Measure toxicity by quantifying the number of live/dead cells, cell membrane integrity and glutathione (GSH) levels.
Hematopoietic Cell Toxicity Examine cytotoxic effects of pre-clinical compounds or biologics on adult stem cells.

Show all 7 in In Vitro Toxicology 1 more

HepaRG Cells Obtain terminally differentiated and cryopreserved hepatic cells that retain many characteristics of primary human hepatocytes.

In Vivo ADME

In Vivo Radiolabeled Metabolism Determine the qualitative and quantitative metabolism and/or degradation of an active ingredient in animals.

Market Access

Communication & Advertisement Distribution of a range of materials, through various communication channels, to highlight a message containing scientific-related topics
Life Science Reports Life Science reports
Marketing and Commercialization Identify, promote and prove the value of a particular drug to key stakeholders.

Model Development

3D Blood-Brain Barrier Model Use an in vitro 3D blood–brain barrier model for real-time visualization of cellular and barrier functions.

Non-Human Biospecimen

Dog / Canine Cells Acquire fresh or frozen cells including but not limited to RBCs, WBCs, PBMCs, endothelial cells, T cells, fibroblasts, hepatocytes, splenocytes, etc.
Goat Cells, Tissues, and Biofluids Acquire fresh or frozen cells, tissues, and biofluids including but not limited to whole blood, PBMCs, tissue slides, etc.
Monkey / Non-Human Primate / NHP Cells Acquire fresh or frozen cells including but not limited to RBCs, WBCs, PBMCs, endothelial cells, T cells, fibroblasts, hepatocytes, splenocytes, etc.
Mouse Cells Acquire fresh or frozen cells including but not limited to RBCs, WBCs, PBMCs, endothelial cells, T cells, fibroblasts, hepatocytes, splenocytes, etc.
Mouse Tissues Acquire fresh or frozen tissues including but not limited to those from the central nervous system, endocrine system, gastrointestinal system, integumentary system, reproductive system, lymphatic system, etc.
Pig / Minipig / Porcine Cells Acquire fresh or frozen cells including but not limited to RBCs, WBCs, PBMCs, endothelial cells, T cells, fibroblasts, hepatocytes, splenocytes, etc.

Show all 10 in Non-Human Biospecimen 4 more

Pig / Minipig / Porcine Tissues Acquire fresh or frozen tissues including but not limited to those from the central nervous system, endocrine system, gastrointestinal system, integumentary system, reproductive system, lymphatic system, etc.
Rabbit Cells Acquire fresh or frozen cells including but not limited to RBCs, WBCs, PBMCs, endothelial cells, T cells, fibroblasts, hepatocytes, splenocytes, etc.
Rabbit Tissues Acquire fresh or frozen tissues including but not limited to those from the central nervous system, endocrine system, gastrointestinal system, integumentary system, reproductive system, lymphatic system, etc.
Rat Cells Acquire fresh or frozen cells including but not limited to RBCs, WBCs, PBMCs, endothelial cells, T cells, fibroblasts, hepatocytes, splenocytes, etc.

Oncology Models

3D Triculture Breast Cancer Model Use tricultures of breast cancer cell lines, hMSCs, and endothelial tubules for evaluating breast cancer progression.
CAR-T Efficacy In Vivo assessment of CAR-T and CAR-NK efficacy in a humanized mouse
Immuno-PDX Utilize the patient-derived xenograft for drug response profiling and biomarker discovery of immuno-oncology drug candidates.
Oncology Derived PDX Patient derived xenografts derived from various oncological samples. This includes, but is not limited to, samples from Lymphoma, Melanoma, and Leukemia.
Ovarian Cancer Mouse Measure therapeutic endpoints in animal models of ovarian cancer.
T11 (Breast Cancer) Measure therapeutic endpoints in animal models of breast cancer.

Show all 7 in Oncology Models 1 more

Xenograft Models Measure therapeutic endpoints in cancer models using tumor cells transplanted from a donor of a different species.

Other Specialty Toxicology

Biosafety Testing In Vitro Test biologics, raw materials, lot release and viral safety
Tumorigenicity Testing Test tumor-forming properties of cell products.

Protein Sciences

Cytokines Find recombinant cytokines or cytokine assays.
Host Cell Protein Analysis Measure contamination of biologics with host proteins by using sequencing, chromatography and the LAL test.
Intracellular Trafficking Intracellular Trafficking is when cells transport molecules and proteins from one location to another within the cell.
Recombinant Proteins Use recombinant DNA to produce proteins in vivo or in vitro.

REACH Services

Ex Vivo REACH Assays Perform testing on cells or tissues cultured directly from a test organism
In Vivo REACH Services Performing testing when in vitro studies cannot be used to predict biological responses

Scientific Data Services

T Cell Epitope Mapping Use peptide libraries make it possible to rapidly identify the epitopes of T-Cells, T-Cell clones, T-Helper Cell Clones, T-cell lines, and unpurified T-cells.

Testing Services

In Vitro Skin Models Measure skin model penetration and invasion, photosensitivity and toxicity.

Other services

3D Force Microscopy of Cells Measure cell-generated forces in 3D biopolymer networks that mimic the physiological situation of living cells.
Qube - High Throughput Screening Screen large compound libraries for ion channel blockers and modulators.

United States Monmouth Junction 2 sites

Professional associations: BioNJ
Website: www.thewellbio.com

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