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BellBrook labs
BellBrook labs is listed as a small business research supplier in the Scientist.com network, with 2 sites in 1 country and 1 service area.
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Services
What this research supplier says it provides, as listed in the Scientist.com network.
Type of company: Small business
Biomarkers
- Lipid Kinase Assays Use biochemical, cell-based or in vivo assays to measure lipid kinase activity.
- Wound Healing Assay Use cell-based assays to investigate cell proliferation, cell migration and wound closure.
Chemistry, Manufacturing and Controls (CMC)
- Integrated Small Molecule Package Process an entire Small Molecule/Compounds Pipeline Project including: Compound Synthesis or Purchase, Compound Analysis/Testing, In Vitro Assays, and Formulation/Reformulation from our bundle of suppliers
Discovery Chemistry
- HTS Libraries Find targeted and broad collections of chemical compounds for high throughput screening and ADMET applications.
Drug Development
- Assay Development Consulting Request consultant services measuring the activity of a drug or biochemical in an organism or organic sample.
- Small Molecule Drug Development Consulting Request consulting services related to small molecule development.
In Vitro Assays
- Antivirals Measure anti-viral activity in biochemical and cell assays.
- Assay Development Construct or create new assays or modify existing ones.
- HTS Assay Development Develop assays to use in high throughput screening.
- In Vitro Assay Development Develop innovative assay and screening methods outside a living organism to enable a wide range of pre-clinical activities.
- Inflammation Assays Identify and validate pro- and anti-inflammatory molecules, recruitment inhibitors and chemotaxis modulators.
- Invasion Assays Monitor and quantify the ability of cultured cells to permeate real or artificial biological barriers.
Show all 39 services
In Vitro Pharmacology
- ATP Competitive Study Determine whether or not a compound is competitive with ATP.
- Drug Target Assays Gain insight into the selectivity and mode-of-action of a compound's pharmacological targets.
- Extracellular signal Regulated Kinase Assays Use biochemical, cell based or in vivo assays to measure ERK enzyme activity.
- G-Protein Coupled Receptor (GPCR) Assays Detect ligand binding, receptor dimerization and downstream signal transduction events.
- High Throughput Screening Conduct millions of chemical, genetic or pharmacological tests in a short period of time.
- Histone Deacetylase (HDAC) Assays Use biochemical, cell-based or in vivo assays to measure histone deacetylase activity.
Show all 23 in In Vitro Pharmacology
- Immuno-oncology Targets Develop drugs that take advantage of the immune system to target cancer cells.
- In Vitro Enzyme Activity Assay Development Develop new in vitro enzyme activity assays or modify existing ones.
- Kinase Assays Measure activity of over 500 kinases in biochemical or cell-based assays.
- Methyltransferase Assays Use biochemical, cell-based or in vitro assays to measure methyltransferase activity.
- Mutant B-Raf Assays Use biochemical, cell based or in vivo assays to measure mutant B-Raf enzyme activity.
- PARP Assays Use biochemical, cell-based or in vivo assays to measure PARP activity.
- Phosphatidylinositol 3-Kinase (PI3K) Assays Use biochemical, cell based or in vivo assays to measure PI3K enzyme activity.
- Phosphodiesterase Assays Measure phosphodiesterase activity in biochemical and cell-based assays.
- Protein Kinase B (Akt) Assays Use biochemical, cell based or in vivo assays to measure Akt enzyme activity.
- Protein Targets Protein Targets are of pharmaceutical interest for drug discovery purposes.
- Protein/Enzyme Targets For requesting Protein/Enzyme Targets
- Raf Assays Use biochemical, cell based or in vivo assays to measure Raf enzyme activity.
- RAS Assays Use biochemical, cell based or in vivo assays to measure RAS enzyme activity.
- Selectivity Profiling Determine the specificity of a ligand for its target by testing it against a large panel of related target proteins.
- Target Identification Identify the target(s) of a biologically active substance.
- Ubiquitin Ligase Assays Measure ligase enzyme activity in the presence of cofactors or chemical modifiers.
- UDP-glucuronosyltransferases (UGT) Inhibition Assays Use biochemical, cell-based or in vivo assays to measure UDP-glucuronosyltransferase activity.
Product Orders
- Kits and Reagents Submit a request to multiple vendors for kits and reagents.
Protein Sciences
- Enzymology Enzymology studies the biochemical activity, structure, and function of enzymes. Two key area of Enzymology are Cytochrome P450...
- Fluorescence Polarization Investigate receptor-ligand interactions, protein-DNA interactions, proteolysis and membrane fluidity.
Other services
- New Request
Service areas:
Where it operates
Sites by country, with the cities in each.
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United States 2 sites
About this supplier
In the supplier's own words, as listed in the Scientist.com network.
BellBrook Labs, LLC develops detection reagents and microfluidic devices that accelerate the discovery of more effective therapies for cancer and other debilitating diseases. The company’s primary technology platform, Transcreener® is a biochemical HTS assay method based on the immunodetection of nucleotide enzyme products. These assays make it easy to screen the thousands of enzymes that generate AMP2/GMP2, GDP, UDP as part of their activity as well as a new platform for detecting methyltransferases. The Transcreener ADP2 Assay, which is the only method for direct detection of ADP, has...
Show the full description
BellBrook Labs, LLC develops detection reagents and microfluidic devices that accelerate the discovery of more effective therapies for cancer and other debilitating diseases.
The company’s primary technology platform, Transcreener® is a biochemical HTS assay method based on the immunodetection of nucleotide enzyme products. These assays make it easy to screen the thousands of enzymes that generate AMP2/GMP2, GDP, UDP as part of their activity as well as a new platform for detecting methyltransferases. The Transcreener ADP2 Assay, which is the only method for direct detection of ADP, has become one of the most widely used assays for kinases, ATPases and other ATP-utilizing enzymes. It is currently used by other assay service providers, including Invitrogen and Evotec, for kinase profiling and screening.
The company’s cell-based assays are based on a proprietary iuvo™ Microconduit Array platform, which enables the use of highly miniaturized, advanced cell models and functional assays with automated liquid handling and HCA platforms. The goal of the iuvo cell-based assays is to provide a more-accurate replication of in vivo processes in drug discovery. In addition to various assay formats for viability, cell cycle, apoptosis, and migration/invasion, BellBrook Labs also offers a 3D Cell-Based Assay Service to provide Screening and Profiling in 3D Biological Matrices. Quantitative potency data includes IC50 values and magnitude of effect, while in situ molecular staining allows pathway and mechanism analysis.
We provide services in:
- Transcreener High Throughput Screening (HTS) Assays: ADP, AMP/GMP, GDP, UDP, EPIGEN methyltransferase, RGScreen, Assay Development
- Enzymes and Assay Kits: methyltransferase assay, RGS protein GAP assay
- IUVO Microconduit Array Platform - cell migration, microchannel 5250, 3D ECM invasion assay, 3D cell-based assay services, 3D ICC Slide for immunostaining
- Website
- www.bellbrooklabs.com
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