Cincinnati Children's Hospital Medical Center Humanized Mouse Resource Core

Cincinnati Children's Hospital Medical Center Humanized Mouse Resource (HMR) Core is a comprehensive resource facility that provides a full range of xenograft mouse strains and services.

The HMR is committed to facilitating and promoting translational research involving viable primary human tissues. Our resource offers umbilical cord blood, mobilized peripheral blood and adult whole bone marrow stem cells from healthy donors in coordination with the Translational Core Labs. Other cell types can be provided by arrangement. We offer access to an immunomagnetic cell sorter (Miltenyi AutoMacs). Expertise in primary human hematopoietic stem/progenitor and leukemic cell culture and manipulation is available.

The HMR offers a unique combination of animal services and mouse strains to assist in the generation of humanized mouse models to fit various needs. The HMR is available to assist in the molecular analysis of xenografted cells in vivo and will support the development of new strains of mice as well as new therapeutic approaches (pharmacologic and/or cell-based) that could lead to translational Phase I and II studies. The HMR will facilitate the sharing of expertise and promote interaction among investigators utilizing the HMR.