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Crown Bioscience Germany GmbH
Crown Bioscience Germany GmbH is listed as a mid sized business research supplier in the Scientist.com network, with 1 site in 1 country.
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Services
What this research supplier says it provides, as listed in the Scientist.com network.
Type of company: Mid sized business
Antibodies
- Antibody based Assay Development Create specific and sensitive assays for the immunodetection of disease-specific target antigens.
- Immunodetection Use antibodies to identify a protein or antigen.
Biomarkers
- Anatomic Pathology Do macroscopic, microscopic, biochemical, immunologic and molecular examination of organs and tissues.
- Biomarker Clinical Validation Evaluate the predictive ability of a candidate biomarker for a disorder.
- Biomarker Discovery Identify a biomarker associated with disease progression of disease, effectiveness of therapy or diagnosis of disease or condition.
- Biomarker Screening Biomarker testing analyzes tissue, blood, or fluid samples to identify specific genes, proteins, or molecules that indicate disease, particularly cancer.
- Biomarker Services Evaluating normal/abnormal biological conditions and characteristics within the body
- Cytokine Release Assay Use in vivo or in vitro assays to detect unregulated or excessive release of pro-inflammatory cytokines.
Show all 21 in Biomarkers
- Digital Pathology Acquire, manage and interpret pathology information generated from a digital image of a slide preparation of cells or tissue.
- Flow Cytometry Identify fluorescently-labeled cells or physically separate cells from a larger population using biomarkers.
- Fluorescent In Situ Hybridization Use FISH to identify abnormal chromosome structures and to quantify specific DNA sequences.
- Genomics Genomic services including applications to DNA (*sanger sequencing, whole genome amplification, library screening, cloning, sub-cloning, and DNA isolation*) and RNA (*microRNA analysis, RNA isolation, qRT-PCR, mRNA...
- Hematoxylin & Eosin (H&E) Staining Visualize microscopic structures in cells or tissues.
- Histopathology Evaluate slide preparation of cells or tissues for abnormal features.
- Immunoassays Create antibody-based assays for the identification and quantification of specific antigens.
- Immunohistochemistry Examine the toxic effects of pre-clinical compounds in small animal and patient histological samples.
- Immunophenotyping Separate cell types based on their expression of biomarkers or based on their individual and unique expression patterns.
- Immunostaining Use labeled antibodies to detect proteins or other antigens in cells or tissues.
- Molecular Profiling Modify genome activity without changing the DNA sequence.
- Paraffin-based Histology Perform sectioning and histological analysis of wax-embedded samples.
- Predictive Biomarkers Discovery Identify candidate biomarkers suggestive of a response to a treatment.
- Prognostic Biomarkers Discovery Identify candidate biomarkers representative of disease progression without treatment.
- Special Stainings Use a variety of techniques for the selective visualization of specific tissue or cell types.
Cell Culture and Characterization
- Adherent Cell Culture Grow monolayers of anchorage-dependent cells.
- Cell and Tissue Histology Prepare and stain frozen, fixed and embedded (FFPE) tissue samples.
- Cell Culture Culture primary or immortalized cell lines.
- Cell Sorting The purpose of cell separation is to isolate a cell population from other cells in a biological sample.
- Cryo-based Histology Perform sectioning and histological analysis of frozen non-fixed samples.
- Explant Culture Culture cells obtained from a part or parts of an in vivo structure.
Show all 12 in Cell Culture and Characterization
- H & E Services For requesting services related to H&E Services
- Histology Examine by microscopy the anatomy of cells and tissues of clinical patients and animal models.
- Multiplex Immunofluorescence Multiplex immunofluorescence (mIF) is an advanced tissue-imaging technique that allows researchers to simultaneously detect and visualize multiple protein markers within a single tissue section
- Signaling Pathways Find proteins, assays and custom reagents for the analysis of cell signaling pathways.
- Single Cell DNA Sequencing Examine genetic variations in a single cell.
- Single Cell Services Request services to perform genomics, transcriptomics, proteomics, metabolomics and cell–cell interactions at the single cell level
Show all 115 services
Chemical and Compound Analysis
- Protein Separation and Detection Separate proteins based on properties such as solubility, adsorption or size differences.
Chemical and Compound Testing
- Clinical Pathology Diagnose disease based on the laboratory analysis of bodily fluids, such as blood, urine and tissues.
Clinical Trials
- BioAnalytical Laboratory Services Bioanalytical laboratory services provide essential testing to quantify drugs, metabolites, and biomarkers in biological samples (blood, urine, tissue) to support preclinical and clinical drug development
- Clinical Lab Services Comprehensive testing, analysis, and research support for a medical study.
- Clinical Specialty Laboratory Services Clinical specialty laboratory services provide advanced diagnostic testing and analytical support for healthcare, clinical trials, and research
Data Science/Bioinformatics
- Clinical In Silico Genomics/Transcriptomics Data Analysis A process that helps make sense of your omics data
- Translational Biomarker Discovery An approach to finding markers that change in response to a drug or that identify a group that responds favorably to a specific therapy. These can be omics, molecular, histologic, radiologic, etc.
- Translational Omics Analytics A process to analyze various omics data (genomics, transcriptomics, proteomics, metabolomics, etc.) This can include the integration of different omics data. Helps to better understand the molecular environment...
Discovery Chemistry
- Bioanalytical Lab Services Bioanalytical Lab Services
Disease Models
- Precision Cut Lung Slices (PCLS) Use a phenotypically accurate model of lung behavior for screening and target validation.
DNA & RNA
- Amplicon - HLA Typing Use an amplicon sequencing method to identify allelic variation within the HLA genes.
- Cell Free DNA Assay Detect known mutations and discover new ones in cell-free plasma DNA.
- Digital Polymerase Chain Reaction Obtain improved absolute target quantification and rare allele detection compared to conventional qPCR.
- DNA Extraction Extract DNA from an original source.
- DNA Sequencing Determine the nucleotide sequence of DNA samples.
- DNA/RNA Extraction & Purification DNA/RNA Extraction & Purification.
Show all 25 in DNA & RNA
- Droplet Digital PCR (ddPCR) ddPCR is a molecular technique for absolute, highly precise quantification of DNA or RNA
- Exome Sequencing Determine protein-coding nucleotide sequences in a DNA sample.
- Genomic DNA Purification Isolate genomic DNA from cells or tissue samples.
- Integrated Genomics Package Process an entire Genomics Pipeline Project including: Sample Preparation, Target Enrichment, NGS Instrumentation, and Data Analysis from our Bundle of Suppliers
- Long Read Sequencing Long read sequencing is used in genomics to sequence long fragments of DNA, enabling the ability to span complex regions of the genome.
- Metagenomic Sequencing Sequence genetic material recovered directly from environmental samples
- miRNA sequencing Identify miRNAs by Next Generation Sequencing and bioinformatic analysis.
- NGS: Next Generation Sequencing Sequence millions of template DNA molecules in parallel.
- qPCR Analysis Measure the accumulation of PCR products in real time.
- Quantitative RT PCR Use quantitative reverse transcription polymerase chain reaction to measure absolute and relative mRNA abundance.
- RNA Extraction Isolate total RNA or mRNA from cells or tissues
- RNA Sequencing Use Next Generation Sequencing techniques to Identify RNA transcripts, examine differential expression patterns and analyze splice variants.
- RNA Services Whether you’re isolating total RNA for whole genome expression analysis by microarray or setting up high content screening by s...
- RNAscope In Situ Assays Profile single-cell gene expression in situ.
- RNAseq and DNAseq library preparation and sequencing DNA/RNA sequencing and preparations
- Sequence Based Methylation Analysis Detect DNA methylation sites within cytosine-phosphate-guanine (CpG) dinucleotides at single base-pair resolution.
- Single Cell RNA Sequencing Quantify mRNA variants in a single cell.
- Spatial Transcriptomics Determine the sub-cellular localization of mRNA molecules. Use this to identify cellular heterogeneity in tissues, tumors, immune cells and the subcellular distribution of transcripts.
- Whole Transcriptome Sequencing Whole Transcriptome Sequencing (WTS), or total RNA-Seq, is a comprehensive Next-Generation Sequencing (NGS) technique that analyzes all RNA types, including coding (mRNA) and non-coding RNA (lncRNA, miRNA), within...
Drug Development
- Assay Development Consulting Request consultant services measuring the activity of a drug or biochemical in an organism or organic sample.
Human Biological Samples
- Biospecimen Finder Explore listings of Human Biological Samples from the suppliers on the scientist.com HBS database
- Custom FFPE cell line blocks Custom IHC compatible FFPE cell line blocks and sections
- HBS Autoimmune Diseases For requesting Autoimmune Diseases HBS.
- HBS Healthy/Controls For requesting HBS Healthy/Controls
- HBS Leukemia For requesting HBS Leukemia
- HBS NSCLC For requesting HBS NSCLC
Show all 23 in Human Biological Samples
- HBS Oncology For requesting Human biospecimens from Oncology indications
- HBS: Human Biological Samples Request human biosamples including tissues, blood, serum, bone marrow, tissue microarrays, etc.
- Human Blood Acquire fresh/frozen human blood based on patient demographics, disease stage, history and treatment.
- Human Buffy Coats Acquire fresh/frozen Buffy Coats based on patient demographics, disease stage, treatment and history.
- Human Cell Lysates For requesting human Cell lysates.
- Human Fixed Tissue Acquire Human fixed tissue based on patient demographics, disease stage, history and treatment.
- Human Fresh Tissue For requesting fresh human tissue
- Human Frozen Tissue For requesting frozen human tissue.
- Human Peripheral Blood Mononuclear Cells (PBMCs) Acquire fresh/frozen normal PBMCs based on patient demographics and history.
- Human Plasma Acquire fresh/frozen human plasma
- Human Red Blood Cells Acquire fresh/frozen normal red blood cells based on patient demographics and history.
- Human Serum Acquire fresh/frozen normal serum based on patient demographics and history.
- Human TMA For requesting Human Tissue MicroArrays
- Human Urine Acquire fresh/frozen normal urine based on patient demographics and history.
- Human Whole Blood Acquire fresh/frozen normal whole blood based on patient demographics and history.
- Liquid Biopsy Test and detect either circulating tumor cell-associated biomarkers or circulating tumor DNA.
- Tumor Cells Acquire tumor cells (either human or animal)
In Vitro ADME
- Metabolite Identification and Profiling Estimate drug candidate metabolites after administration of drug to an animal or human subject.
In Vitro Assays
- Assay Development Construct or create new assays or modify existing ones.
- Fully Automated Assays Develop and perform assays that require no manual steps
- Human Custom TMA For requesting Human Custom Microarray Services
- Inflammation Assays Identify and validate pro- and anti-inflammatory molecules, recruitment inhibitors and chemotaxis modulators.
In Vitro Pharmacology
- Immuno-oncology Assays Use biochemical, cell based or in vivo assays to measure the activity of immuno-therapy targets.
- In Vitro Enzyme Activity Assay Development Develop new in vitro enzyme activity assays or modify existing ones.
- Target Validation Demonstrate that modification of target activity has potential therapeutic benefits.
Lab Supplies, Facilities, and Equipment
- Biobanking Store and track biological samples.
Model Development
- Human Precision-Cut Intestinal Slice Model Acquire a fresh phenotypically-accurate model to study human intestinal behavior.
- Human Precision-Cut Lung Slice Model Acquire a fresh phenotypically-accurate model to study human lung behavior.
Oncology Models
- Oncology Models Use model organisms to test the therapeutic efficacy of cancer drug candidates.
Protein Sciences
- ELISA Detect the presence of antigens recognized by antibodies or find antibodies that recognize an antigen.
- Protein Post-translational Modification Analysis Measure glycosylation, phosphorylation, sulfation, ubiquitination, methylation and acetylation.
- Proteomics Do large-scale experimental analysis of proteins focused on understanding structure and function.
- Western Blots Detect specific proteins in a sample of tissue homogenate or extract.
Scientific Data Services
- Epigenomics Data Analysis Quantify and analyze DNA methylation and/or DNA binding protein data sets.
- Metagenomics Data Analysis Deconvolute the genetic content of genomes contained in environmental samples by utilizing whole genome sequencing techniques to provide insight into microbial communities and host phenotypes.
- Microbiome Data Analysis Determine the population composition of a microbial community and analyze its contribution to human or animal health.
- Mutation Data Profiling Guide treatment decisions in cancer based on the identification of genomic mutations .
- NGS: Next Generation Sequencing Data Analysis Use software to interpret data created by RNA-Seq, DNA-Seq, ChIP-Seq and DNA methylation experiments.
- Website
- www.biospecimenservices.com
Where it operates
Sites by country, with the cities in each.
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Germany 1 site
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