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Mimetas B.V.
Mimetas B.V. is listed as a mid sized business research supplier in the Scientist.com network, with 2 sites in 2 countries.
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Sites
2
Countries
2
Services
What this research supplier says it provides, as listed in the Scientist.com network.
Type of company: Mid sized business
Biomarkers
- Cell Migration Assays Measure chemotaxis, haptotaxis, transmigration and wound-healing.
- Chemotaxis Assays Investigate the in vivo or in vitro movement of cells towards or away from a chemotactic agent.
- Cytokine Release Assay Use in vivo or in vitro assays to detect unregulated or excessive release of pro-inflammatory cytokines.
Cell Culture and Characterization
- 3D Cell Culture Use a scaffold-based or scaffold-free format to grow three dimensional cell and tissue structures.
- Explant Culture Culture cells obtained from a part or parts of an in vivo structure.
- In Vitro Hydrogel-Based Culture of PDXs Enable the extended laboratory culture of cancer PDXs and other primary cells in 3D.
- Microphysiological system (MPS)/organoid analytics microTMA produced from fixed microtissues (MPS)
- Organotypic Culture Co-culture different cells to enable in vitro growth of an in vivo tissue or organ equivalent.
Discovery Chemistry
- Lead Optimization Perform chemical structural changes to improve preclinical drug candidate.
Disease Models
- Inflammation Models Measure therapeutic endpoints in animal models for inflammation.
- Inflammatory Bowel Disease Models Measure IBD symptom severity, cytokine levels and body weight, and evaluate IHC and Ariol images.
- Liver Fibrosis Models Measure liver fibrosis using therapeutic endpoints such as collagen assessment, TUNEL staining and inflammatory markers.
- LPS Lung Inflammation Models Measure therapeutic endpoints in animal models of inflammation.
- Neuroscience Models Test therapeutic efficacy of drug candidate in neurological disease model.
- Parkinson's Disease Models Measure therapeutic endpoints in animal models of Parkinson's disease.
Show all 66 services
General in vivo Toxicology
- General Toxicology Use in vivo models to assess acute and sub-acute toxicity as well as chronic and sub-chronic toxicity.
Human Biological Samples
- FRBESaHBS Request human biosamples including tissues, blood, serum, bone marrow, and tissue microarrays.
- Human Organoids Test immuno-oncology drugs and therapies on fresh, unpropagated 3D tumor organoids to evaluate efficacy and understand drug mechanism of action. Understand the intact tumor immune microenvironment, cytotoxic efficacy...
- Human Organs-On-Chips Use Organs-On-Chips for target identification and validation, target-based screening, and phenotypic screening.
In Vitro ADME
- Blood Brain Barrier Measure movement of drugs from circulating blood to brain extracellular fluid.
- Caco-2 Cell Permeability Measure passive diffusion of drugs across Caco2 cell monolayers.
- Cell Permeability and Absorbance Models Cell Permeability and Absorbance Model assay.
- Drug Drug Interactions Determine whether a substance affects the activity of a drug when both are administered together.
- HT ADME (High-Throughput Absorption, Distribution, Metabolism and Excretion) Analyze the process and effects of a chemical that is ingested by an organism using an advanced technological screening process. Use for drug...
- Human Blood Brain Barrier on a Chip (BBBoC) Create a blood–brain barrier multicellular model to test drug delivery to the brain.
Show all 9 in In Vitro ADME
- In Vitro ADME in Vitro ADME services
- Intestinal Permeability Use Caco 2 and MCDK cells to assess mono-directional drug transport by passive diffusion in culture.
- Membrane Transporters Use Caco 2 cells to assess bi-directional drug transport in the presence or absence of P-glycoprotein (P-gp) inhibitors.
In Vitro Assays
- 3D Cell Microscopy Assay Investigate cellular and subcellular events in three dimensional 3D cultures by using fluorescence microscopy.
- Apoptosis Assays Detect apoptotic events that lead to programmed cell death.
- Assay Development Construct or create new assays or modify existing ones.
- Caspase Assay Detect early to mid stage apoptosis or differentiate apoptosis from necrosis.
- Cell Based Assays Apply compounds to cells and test for cellular phenotypes and effects on gene expression
- Cell Proliferation Measure cell number, cell viability and cell division.
Show all 17 in In Vitro Assays
- Cell-based Screening Assays Apply compounds to cells and test for cellular phenotypes and effects on gene expression
- High Content Screening Analyze whole cells or components of cells with simultaneous readout of several parameters.
- HTS Assay Development Develop assays to use in high throughput screening.
- In Vitro Assay Development Develop innovative assay and screening methods outside a living organism to enable a wide range of pre-clinical activities.
- In Vitro Efficacy Test Use in vitro models to test the efficacy of your products.
- In Vitro Human Cell Assays Request in vitro human cells for assays
- Inflammation Assays Identify and validate pro- and anti-inflammatory molecules, recruitment inhibitors and chemotaxis modulators.
- Invasion Assays Monitor and quantify the ability of cultured cells to permeate real or artificial biological barriers.
- Organoid Screening Assay Evaluate the effects of various substances, such as drugs or genetic modifications, on organoids.
- Phenotype Assays Measure effects of drug candidate on the morphology or function of cells and whole animals.
- Tube Formation Assay Monitor the in vitro formation of three dimensional 3D tube structures.
In Vitro Pharmacology
- Immuno-oncology Assays Use biochemical, cell based or in vivo assays to measure the activity of immuno-therapy targets.
- In Vitro Disease Models Screen pre-clinical candidates without the use of live animals.
- In Vitro Hepatotoxicity Assays Use in vitro assays to measure hepatoxicity-related activities.
- In Vitro Hypoxia Models Use in vitro models to measure therapeutic endpoints associated with hypoxia.
- In Vitro Neural Models Use cultured neurons, neuronal progenitor cells and stem cell differentiation to create cellular models of neurological disease.
- In Vitro Oncology Models Use cell-based and biochemical models of cancer.
Show all 7 in In Vitro Pharmacology
- Transporter Assays Use biochemical, cell-based or in vitro assays to measure transporter target activity.
In Vitro Toxicology
- Cytotoxicity Test for effects on cell viability and proliferation
- Cytotoxicity Testing Determine whether a cosmetic product or ingredient is toxic to in vitro cell cultures.
- Endothelial Cell Toxicity Assess the cytotoxic effects of pre-clinical compounds on the vascular system.
- Hepatocyte Toxicity Assess the cytotoxic effects of pre-clinical compounds on hepatocytes purified from patients and animal models.
- Toxicology- in vitro Toxicity testing and model development in vitro on developmental and adult neurotoxicity
- Tubule Epithelial Cell Toxicity Assess the cytotoxic effects of pre-clinical compounds on the kidney.
Model Development
- 3D Blood-Brain Barrier Model Use an in vitro 3D blood–brain barrier model for real-time visualization of cellular and barrier functions.
Oncology Models
- 3D Triculture Breast Cancer Model Use tricultures of breast cancer cell lines, hMSCs, and endothelial tubules for evaluating breast cancer progression.
- Angiogenesis Models Measure therapeutic endpoints in animal models of angiogenesis.
- Oncology Models Use model organisms to test the therapeutic efficacy of cancer drug candidates.
Protein Sciences
- Cytokines Find recombinant cytokines or cytokine assays.
Safety Pharmacology
- Safety Pharmacology Assess the impact of a therapeutic for human use on vital organ systems before first-in-man drug testing.
Testing Services
- In Vitro Toxicology Testing Non-animal testing employing US and international methodologies for determining irritation and other undesirable potentials.
Other services
- New Request
- Website
- www.mimetas.com
Where it operates
Sites by country, with the cities in each.
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Netherlands 1 site
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United States 1 site
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