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Clinical trial

Pilot Study of Redirected Autologous T-cells Engineered to Contain Anti-CD19 Attached to TCR and 4-1BB Signaling Domains in Patient With Chemotherapy Resistant or Refractory CD19+ Leukemia and Lymphoma

NCT01029366 is registered in ClinicalTrials.gov with University of Pennsylvania as lead sponsor.

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Registry record

As filed in ClinicalTrials.gov.

Title
Pilot Study of Redirected Autologous T-cells Engineered to Contain Anti-CD19 Attached to TCR and 4-1BB Signaling Domains in Patient With Chemotherapy Resistant or Refractory CD19+ Leukemia and Lymphoma
Lead sponsor
University of Pennsylvania
Phase
Phase 1
Overall status
Completed
Start date
March 17, 2010
Completion date
May 31, 2016
Enrollment
26 (actual)
Sites
1

Conditions

As the registry lists them; a condition with its own page is linked.

adult acute lymphoblastic leukemia in remission, b-cell adult acute lymphoblastic leukemia, b-cell chronic lymphocytic leukemia, hematopoietic/lymphoid cancer, prolymphocytic leukemia, recurrent adult diffuse large cell lymphoma, recurrent grade 1 follicular lymphoma, recurrent grade 2 follicular lymphoma, recurrent grade 3 follicular lymphoma, recurrent mantle cell lymphoma, refractory chronic lymphocytic leukemia, stage iii adult diffuse large cell lymphoma, stage iii chronic lymphocytic leukemia, stage iii grade 1 follicular lymphoma, stage iii grade 2 follicular lymphoma, stage iii grade 3 follicular lymphoma, stage iii mantle cell lymphoma, stage iv adult diffuse large cell lymphoma, stage iv chronic lymphocytic leukemia, stage iv grade 1 follicular lymphoma, stage iv grade 2 follicular lymphoma, stage iv grade 3 follicular lymphoma, stage iv mantle cell lymphoma