Condition (MeSH)
Gender Dysphoria
ClinicalTrials.gov lists 82 trials for Gender Dysphoria or a narrower condition beneath it.
Search trials, drugs, companies and investigators, and follow each one to the others. Individual plan, $249/seat/mo. Card required.
Trials per phase (log scale)
82 of the 82 trials are tagged with Gender Dysphoria itself; the rest are tagged with a narrower condition beneath it.
When did Gender Dysphoria trials start? (13)
Shown in this order: most recent first, 1990 onwards. 2026 is partial: trials registered with a 2026 start date so far, not a full year. 1 trial is registered to start in 2027 or later, and not listed here.
Trials over time, by phase
- Phase 1
- Phase 1/2
- Phase 2/3
- Phase 3
- Phase 4
- Not applicable
- Observational
Top of scale: 15
Trials registered with a start date in each year, 1990 onward, stacked by phase (complete years only; the current partial year is in the table's notes). The table below lists the same counts, most recent years first.
| Year | Trials started |
|---|---|
| 2026 (partial year) | 3 |
| 2025 | 7 |
| 2024 | 10 |
| 2023 | 5 |
| 2022 | 15 |
| 2021 | 9 |
| 2020 | 10 |
| 2019 | 9 |
| 2018 | 4 |
| 2017 | 6 |
Showing 10 of 13 earlier years.
Forecast of the full-year count, planned starts included, not rows of this table: about 5 trials starting in 2026 and about 7 in 2027, the average of the 24 months through September, counted as registered and carried forward. The rows of this table count trials registered so far with a start date in the year, planned starts included; the forecast looks ahead to the count for the whole year, so it is not the same measure. In backtests on conditions of this size, forecasts made part-way through the year were typically off by about 28 percent and ran about 20 percent low against the count later registered; forecasts made before the year began were off by about 39 percent and ran about 37 percent low against the count later registered. These figures rest on a few years of history (target years from 2018 to 2025, varying by figure), place each condition as it is mapped today rather than as it was then, and score against a count for the newest year that was still being revised. Only condition series were scored.
Prediction, not a registry value: median of 36 months from start to primary completion across 7 trials still running at the 2026-10-09 snapshot; registered median of 19 months across 30 trials with a primary completion typed Actual. Source: ClinicalTrials.gov / AACT (CTTI), public domain.
What phase are Gender Dysphoria trials in? (7)
Shown in this order: phase order.
Show the trials by phase as a table
| Phase | Trials |
|---|---|
| Phase 1 | 1 |
| Phase 1/2 | 1 |
| Phase 2/3 | 1 |
| Phase 3 | 3 |
| Phase 4 | 6 |
| Not applicable | 19 |
| Observational | 51 |
How many Gender Dysphoria trials are recruiting? (8)
Shown in this order: the order a trial moves through, from not yet recruiting to unknown.
| Status | Trials |
|---|---|
| Not yet recruiting | 4 |
| Recruiting | 26 |
| Enrolling by invitation | 3 |
| Active, not recruiting | 2 |
| Completed | 25 |
Showing 5 of 8 statuses.
Status as registered on ClinicalTrials.gov. Each trial is counted once.
Which drugs are being tested for Gender Dysphoria? (2)
Shown in this order: most trials first. One row per drug, matched to a single molecule under all its names, ranked by number of trials.
| Drug | Trials |
|---|---|
| Estradiol | 7 |
| Lynestrenol | 2 |
Interventions as named in the registry (13)
Shown in this order: most trials first.
| Drug | Trials |
|---|---|
| Testosteron | 4 |
| gender affirming hormone therapy | 3 |
| Cyproterone Acetate | 3 |
| Use of topical estradiol | 1 |
| Local Anesthetic | 1 |
Showing 5 of 13 interventions.
These are the names sponsors entered on ClinicalTrials.gov that we have not matched to a single molecule. Some are drugs under a brand or code name; others are procedures, doses or arm labels.
Which publications cover Gender Dysphoria? (23)
Shown in this order: major-topic papers first, then newest, then most linked to trials.
| Publication | Journal | Year | Major topic |
|---|---|---|---|
| Gender affirming hormone therapy for individuals with gender dysphoria aged <26 years: a systematic review and meta-analysis. | Archives of disease in childhood | 2025 | Yes |
| Excess costs of transgender and gender-diverse people with gender incongruence and gender dysphoria compared with people from the general population in Germany: a secondary analysis using data from a randomised controlled trial and a representative telephone survey. | BMJ open | 2025 | Yes |
| Use of gonadotropin-releasing hormone agonists in transgender and gender diverse youth: a systematic review. | Frontiers in endocrinology | 2025 | Yes |
| Gender Dysphoria and Sexual Euphoria: A Bayesian Perspective on the Influence of Gender-Affirming Hormone Therapy on Sexual Arousal. | Archives of sexual behavior | 2024 | Yes |
| Evolution and trends in referrals to a specialist gender identity unit in Spain over 10 years (2012-2021). | The journal of sexual medicine | 2023 | Yes |
Showing 5 of 23 publications.
Not on this page
Not measured: delivery record.
Checked, with nothing recorded for this condition: lead sponsors, serious adverse events in this condition's trials, prevalence, rare-disease identity, and sub-conditions in mesh.