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Condition (MeSH)

Gender Dysphoria

ClinicalTrials.gov lists 82 trials for Gender Dysphoria or a narrower condition beneath it.

MeSH D000068116 Mental Disorders F03
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Phase 1 Phase 1 1 Phase 1/2 Phase 1/2 1 Phase 2/3 Phase 2/3 1 Phase 3 Phase 3 3 Phase 4 Phase 4 6 Not applicable Not applicable 19 Observational Observational 51 Phase 1 Phase 1 1 Phase 1/2 Phase 1/2 1 Phase 2/3 Phase 2/3 1 Phase 3 Phase 3 3 Phase 4 Phase 4 6 Not applicable Not applicable 19 Observational Observational 51

Trials per phase (log scale)

82 of the 82 trials are tagged with Gender Dysphoria itself; the rest are tagged with a narrower condition beneath it.

Get the Gender Dysphoria report as a PDF

The PDF carries up to 50 rows of each section, where the page shows the first few, with the sources listed. Enter a work email and confirm it from the message we send, and the report follows by email.

When did Gender Dysphoria trials start? (13)

Shown in this order: most recent first, 1990 onwards. 2026 is partial: trials registered with a 2026 start date so far, not a full year. 1 trial is registered to start in 2027 or later, and not listed here.

Trials over time, by phase

  • Phase 1
  • Phase 1/2
  • Phase 2/3
  • Phase 3
  • Phase 4
  • Not applicable
  • Observational

Top of scale: 15

2010: 1 trials (Phase 4 1) 2011: 1 trials (Observational 1) 2015: 1 trials (Phase 1/2 1) 2017: 6 trials (Observational 3, Not applicable 2, Phase 4 1) 2018: 4 trials (Observational 3, Not applicable 1) 2019: 9 trials (Observational 8, Not applicable 1) 2020: 10 trials (Observational 8, Not applicable 1, Phase 4 1) 2021: 9 trials (Observational 6, Not applicable 2, Phase 3 1) 2022: 15 trials (Observational 8, Not applicable 3, Phase 4 3, Phase 1 1) 2023: 5 trials (Observational 1, Not applicable 3, Phase 2/3 1) 2024: 10 trials (Observational 5, Not applicable 4, Phase 3 1) 2025: 7 trials (Observational 5, Not applicable 1, Phase 3 1)

Trials registered with a start date in each year, 1990 onward, stacked by phase (complete years only; the current partial year is in the table's notes). The table below lists the same counts, most recent years first.

Trials started per year
Year Trials started
2026 (partial year) 3
2025 7
2024 10
2023 5
2022 15
2021 9
2020 10
2019 9
2018 4
2017 6

Forecast of the full-year count, planned starts included, not rows of this table: about 5 trials starting in 2026 and about 7 in 2027, the average of the 24 months through September, counted as registered and carried forward. The rows of this table count trials registered so far with a start date in the year, planned starts included; the forecast looks ahead to the count for the whole year, so it is not the same measure. In backtests on conditions of this size, forecasts made part-way through the year were typically off by about 28 percent and ran about 20 percent low against the count later registered; forecasts made before the year began were off by about 39 percent and ran about 37 percent low against the count later registered. These figures rest on a few years of history (target years from 2018 to 2025, varying by figure), place each condition as it is mapped today rather than as it was then, and score against a count for the newest year that was still being revised. Only condition series were scored.

Prediction, not a registry value: median of 36 months from start to primary completion across 7 trials still running at the 2026-10-09 snapshot; registered median of 19 months across 30 trials with a primary completion typed Actual. Source: ClinicalTrials.gov / AACT (CTTI), public domain.

What phase are Gender Dysphoria trials in? (7)

Shown in this order: phase order.

Show the trials by phase as a table
Trials by phase
Phase Trials
Phase 1 1
Phase 1/2 1
Phase 2/3 1
Phase 3 3
Phase 4 6
Not applicable 19
Observational 51

How many Gender Dysphoria trials are recruiting? (8)

Shown in this order: the order a trial moves through, from not yet recruiting to unknown.

Trials by recruitment status
Status Trials
Not yet recruiting 4
Recruiting 26
Enrolling by invitation 3
Active, not recruiting 2
Completed 25

Status as registered on ClinicalTrials.gov. Each trial is counted once.

Which drugs are being tested for Gender Dysphoria? (2)

Shown in this order: most trials first. One row per drug, matched to a single molecule under all its names, ranked by number of trials.

Drugs tested
Drug Trials
Estradiol 7
Lynestrenol 2

Interventions as named in the registry (13)

Shown in this order: most trials first.

Interventions as named in the registry
Drug Trials
Testosteron 4
gender affirming hormone therapy 3
Cyproterone Acetate 3
Use of topical estradiol 1
Local Anesthetic 1

These are the names sponsors entered on ClinicalTrials.gov that we have not matched to a single molecule. Some are drugs under a brand or code name; others are procedures, doses or arm labels.

Which publications cover Gender Dysphoria? (23)

Shown in this order: major-topic papers first, then newest, then most linked to trials.

Not on this page

Not measured: delivery record.

Checked, with nothing recorded for this condition: lead sponsors, serious adverse events in this condition's trials, prevalence, rare-disease identity, and sub-conditions in mesh.

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