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Condition (MeSH)

Brain Injuries, Traumatic

ClinicalTrials.gov lists 2,158 trials for Brain Injuries, Traumatic or a narrower condition beneath it. VA Office of Research and Development has the most among industry and government lead sponsors, with 76.

MeSH D000070642 Nervous System Diseases C10 C26
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Phase 1 Phase 1 87 Phase 1/2 Phase 1/2 31 Phase 2 Phase 2 144 Phase 2/3 Phase 2/3 23 Phase 3 Phase 3 74 Phase 4 Phase 4 65 Not applicable Not applicable 1,059 Observational Observational 675 Phase 1 Phase 1 87 Phase 1/2 Phase 1/2 31 Phase 2 Phase 2 144 Phase 2/3 Phase 2/3 23 Phase 3 Phase 3 74 Phase 4 Phase 4 65 Not applicable Not applicable 1,059 Observational Observational 675

Trials per phase (log scale)

1,668 of the 2,158 trials are tagged with Brain Injuries, Traumatic itself; the rest are tagged with a narrower condition beneath it.

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The PDF carries up to 50 rows of each section, where the page shows the first few, with the sources listed. Enter a work email and confirm it from the message we send, and the report follows by email.

When did Brain Injuries, Traumatic trials start? (31)

Shown in this order: most recent first, 1990 onwards. 2026 is partial: trials registered with a 2026 start date so far, not a full year. 12 trials are registered to start in 2027 or later, and not listed here.

Trials over time, by phase

  • Phase 1
  • Phase 1/2
  • Phase 2
  • Phase 2/3
  • Phase 3
  • Phase 4
  • Not applicable
  • Observational

Top of scale: 157

1996: 2 trials (Not applicable 1, Phase 2 1) 1997: 1 trials (Phase 2 1) 1998: 2 trials (Observational 1, Phase 3 1) 1999: 1 trials (Not applicable 1) 2000: 2 trials (Observational 1, Not applicable 1) 2001: 3 trials (Observational 1, Phase 3 1, Phase 1 1) 2002: 14 trials (Observational 2, Not applicable 1, Phase 4 3, Phase 3 3, Phase 2 1, Phase 1/2 1, Phase 1 3) 2003: 20 trials (Observational 5, Not applicable 5, Phase 4 4, Phase 3 1, Phase 2/3 3, Phase 2 2) 2004: 16 trials (Observational 5, Not applicable 6, Phase 4 2, Phase 3 1, Phase 2/3 1, Phase 1 1) 2005: 18 trials (Observational 4, Not applicable 8, Phase 4 2, Phase 3 1, Phase 2 3) 2006: 19 trials (Observational 4, Not applicable 5, Phase 3 3, Phase 2/3 2, Phase 2 1, Phase 1 4) 2007: 26 trials (Observational 10, Not applicable 5, Phase 4 4, Phase 3 3, Phase 2/3 1, Phase 2 1, Phase 1 2) 2008: 45 trials (Observational 16, Not applicable 17, Phase 4 2, Phase 3 2, Phase 2/3 2, Phase 2 3, Phase 1/2 1, Phase 1 2) 2009: 48 trials (Observational 15, Not applicable 16, Phase 3 3, Phase 2 10, Phase 1/2 1, Phase 1 3) 2010: 59 trials (Observational 23, Not applicable 15, Phase 4 2, Phase 3 5, Phase 2 8, Phase 1/2 2, Phase 1 4) 2011: 77 trials (Observational 32, Not applicable 20, Phase 4 3, Phase 3 3, Phase 2/3 2, Phase 2 9, Phase 1/2 4, Phase 1 4) 2012: 70 trials (Observational 33, Not applicable 22, Phase 4 3, Phase 3 3, Phase 2 2, Phase 1/2 3, Phase 1 4) 2013: 97 trials (Observational 28, Not applicable 47, Phase 4 7, Phase 3 1, Phase 2/3 1, Phase 2 8, Phase 1/2 1, Phase 1 4) 2014: 96 trials (Observational 21, Not applicable 52, Phase 4 2, Phase 3 3, Phase 2 15, Phase 1 3) 2015: 106 trials (Observational 40, Not applicable 52, Phase 4 1, Phase 3 1, Phase 2/3 1, Phase 2 6, Phase 1 5) 2016: 122 trials (Observational 34, Not applicable 68, Phase 4 4, Phase 3 4, Phase 2 7, Phase 1/2 2, Phase 1 3) 2017: 118 trials (Observational 34, Not applicable 72, Phase 4 3, Phase 3 1, Phase 2 5, Phase 1/2 3) 2018: 126 trials (Observational 39, Not applicable 72, Phase 4 1, Phase 3 5, Phase 2 4, Phase 1/2 2, Phase 1 3) 2019: 124 trials (Observational 37, Not applicable 70, Phase 4 1, Phase 3 2, Phase 2/3 2, Phase 2 9, Phase 1/2 1, Phase 1 2) 2020: 111 trials (Observational 35, Not applicable 57, Phase 4 4, Phase 3 3, Phase 2 5, Phase 1/2 1, Phase 1 6) 2021: 157 trials (Observational 52, Not applicable 84, Phase 4 3, Phase 3 5, Phase 2/3 1, Phase 2 3, Phase 1/2 3, Phase 1 6) 2022: 118 trials (Observational 38, Not applicable 68, Phase 3 4, Phase 2 3, Phase 1/2 2, Phase 1 3) 2023: 129 trials (Observational 41, Not applicable 66, Phase 4 3, Phase 3 4, Phase 2 8, Phase 1 7) 2024: 141 trials (Observational 43, Not applicable 74, Phase 4 2, Phase 3 4, Phase 2/3 1, Phase 2 10, Phase 1/2 2, Phase 1 5) 2025: 136 trials (Observational 35, Not applicable 76, Phase 4 4, Phase 3 4, Phase 2/3 3, Phase 2 9, Phase 1/2 1, Phase 1 4)

Trials registered with a start date in each year, 1990 onward, stacked by phase (complete years only; the current partial year is in the table's notes). The table below lists the same counts, most recent years first.

Trials started per year
Year Trials started
2026 (partial year) 137
2025 136
2024 141
2023 129
2022 118
2021 157
2020 111
2019 124
2018 126
2017 118

Showing 10 of 31 earlier years.

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Forecast of the full-year count, planned starts included, not rows of this table: about 140 trials starting in 2026 and about 140 in 2027, the average of the 24 months through September, counted as registered and carried forward. The rows of this table count trials registered so far with a start date in the year, planned starts included; the forecast looks ahead to the count for the whole year, so it is not the same measure. In backtests on conditions of this size, forecasts made part-way through the year were typically off by about 13 percent and ran about 12 percent low against the count later registered; forecasts made before the year began were off by about 19 percent and ran about 17 percent low against the count later registered, and had about the same error as repeating last year's count. These figures rest on a few years of history (target years from 2018 to 2025, varying by figure), place each condition as it is mapped today rather than as it was then, and score against a count for the newest year that was still being revised. Only condition series were scored.

Prediction, not a registry value: median of 36 months from start to primary completion across 237 trials still running at the 2026-10-09 snapshot; registered median of 29 months across 1,218 trials with a primary completion typed Actual. Source: ClinicalTrials.gov / AACT (CTTI), public domain.

What phase are Brain Injuries, Traumatic trials in? (8)

Shown in this order: phase order.

Show the trials by phase as a table
Trials by phase
Phase Trials
Phase 1 87
Phase 1/2 31
Phase 2 144
Phase 2/3 23
Phase 3 74
Phase 4 65
Not applicable 1,059
Observational 675

How many Brain Injuries, Traumatic trials are recruiting? (9)

Shown in this order: the order a trial moves through, from not yet recruiting to unknown.

Trials by recruitment status
Status Trials
Not yet recruiting 127
Recruiting 307
Enrolling by invitation 37
Active, not recruiting 62
Completed 1,021

Showing 5 of 9 statuses.

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Status as registered on ClinicalTrials.gov. Each trial is counted once.

Which lead sponsors run the most Brain Injuries, Traumatic trials? (1)

Shown in this order: most trials first. Lead sponsors the registry classes as industry, NIH, US federal, other government or network. A hospital or university the registry files as government can appear here. Sponsors it classes as academic or other are shown on the full page, because that class cannot separate an institution from a named investigator.

Lead sponsors
Sponsor Trials
VA Office of Research and Development 76

Which drugs are being tested for Brain Injuries, Traumatic? (3)

Shown in this order: most trials first. One row per drug, matched to a single molecule under all its names, ranked by number of trials.

Drugs tested
Drug Trials
DEXMEDETOMIDINE 10
METHYLPHENIDATE 7
PMI-150 (intranasal ketamine) 7

Interventions as named in the registry (12)

Shown in this order: most trials first.

Interventions as named in the registry
Drug Trials
Hyperbaric Oxygen 17
Aerobic exercise 15
amantadine HCl ER 10
Treatment As Usual 10
Acupuncture 9

Showing 5 of 12 interventions.

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These are the names sponsors entered on ClinicalTrials.gov that we have not matched to a single molecule. Some are drugs under a brand or code name; others are procedures, doses or arm labels.

Which serious adverse events do Brain Injuries, Traumatic trials report? (10)

Shown in this order: most subjects affected first. Subjects affected summed across trials, a cross-trial signal, not a rate.

Serious adverse events in this condition's trials
Adverse event Subjects affected Trials
Pneumonia 342 12
Increased intracranial hemorrhage on serial head CT 239 1
CNS 125 1
Shock 121 3
intracranial hypertension 98 1

Showing 5 of 10 adverse events.

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Which publications cover Brain Injuries, Traumatic? (844)

Shown in this order: major-topic papers first, then newest, then most linked to trials.

Publications
Publication Journal Year Major topic
Assessing Task-Dependent Neurophysiology During Virtual Reality Treadmill Training in Adults With Traumatic Brain Injury: A Functional Near-Infrared Spectroscopy Feasibility Study. The Journal of head trauma rehabilitation 2026 Yes
Neurobehavioral Therapy Is Associated With Improvements in Social Functioning in Patients With Functional Seizures and Traumatic Brain Injury. Journal of clinical psychology 2026 Yes
Does Targeting CPP at CPPopt Actually Improve Cerebrovascular Reactivity? A Secondary Analysis of the COGiTATE Randomized Controlled Trial. Neurocritical care 2025 Yes
Feasibility and acceptability for LION, a fully remote, randomized clinical trial within the VA for light therapy to improve sleep in Veterans with and without TBI: An MTBI2 sponsored protocol. PloS one 2025 Yes
Supplement and nutraceutical therapy in traumatic brain injury. Nutritional neuroscience 2025 Yes

Showing 5 of 844 publications.

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Sub-conditions in MeSH (3)

MeSH descendants one level down with at least one trial, most trials first.

Not on this page

Not measured: delivery record.

Checked, with nothing recorded for this condition: prevalence and rare-disease identity.

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