Condition (MeSH)
Univentricular Heart
ClinicalTrials.gov lists 84 trials for Univentricular Heart or a narrower condition beneath it. Actelion has the most among industry and government lead sponsors, with 1.
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Trials per phase
84 of the 84 trials are tagged with Univentricular Heart itself; the rest are tagged with a narrower condition beneath it.
When did Univentricular Heart trials start? (21)
Shown in this order: most recent first, 1990 onwards. 2026 is partial: trials registered with a 2026 start date so far, not a full year.
Trials over time, by phase
- Phase 1
- Phase 1/2
- Phase 2
- Phase 2/3
- Phase 3
- Phase 4
- Not applicable
- Observational
Top of scale: 7
Trials registered with a start date in each year, 1990 onward, stacked by phase (complete years only; the current partial year is in the table's notes). The table below lists the same counts, most recent years first.
| Year | Trials started |
|---|---|
| 2026 (partial year) | 3 |
| 2025 | 4 |
| 2024 | 5 |
| 2023 | 6 |
| 2022 | 6 |
| 2021 | 7 |
| 2020 | 5 |
| 2019 | 7 |
| 2018 | 7 |
| 2017 | 3 |
Showing 10 of 21 earlier years.
No forecast is made for this condition: it averages 4.8 trial starts a year over the five years to September, under the 5 a year the method needs.
Prediction, not a registry value: median of 36 months from start to primary completion across 8 trials still running at the 2026-10-09 snapshot; registered median of 33 months across 56 trials with a primary completion typed Actual. Source: ClinicalTrials.gov / AACT (CTTI), public domain.
What phase are Univentricular Heart trials in? (8)
Shown in this order: phase order.
Show the trials by phase as a table
| Phase | Trials |
|---|---|
| Phase 1 | 4 |
| Phase 1/2 | 2 |
| Phase 2 | 6 |
| Phase 2/3 | 3 |
| Phase 3 | 4 |
| Phase 4 | 2 |
| Not applicable | 26 |
| Observational | 37 |
How many Univentricular Heart trials are recruiting? (7)
Shown in this order: the order a trial moves through, from not yet recruiting to unknown.
| Status | Trials |
|---|---|
| Not yet recruiting | 1 |
| Recruiting | 20 |
| Active, not recruiting | 2 |
| Completed | 47 |
| Terminated | 4 |
Showing 5 of 7 statuses.
Status as registered on ClinicalTrials.gov. Each trial is counted once.
Which lead sponsors run the most Univentricular Heart trials? (1)
Shown in this order: most trials first. Lead sponsors the registry classes as industry, NIH, US federal, other government or network. A hospital or university the registry files as government can appear here. Sponsors it classes as academic or other are shown on the full page, because that class cannot separate an institution from a named investigator.
| Sponsor | Trials |
|---|---|
| Actelion | 1 |
Which drugs are being tested for Univentricular Heart? (3)
Shown in this order: most trials first. One row per drug, matched to a single molecule under all its names, ranked by number of trials.
| Drug | Trials |
|---|---|
| .spironolactone | 1 |
| SILDENAFIL | 1 |
| Iron | 1 |
Interventions as named in the registry (12)
Shown in this order: most trials first.
| Drug | Trials |
|---|---|
| Autologous (self) mononuclear cells derived from umbilical cord blood | 1 |
| Carvedilol CR | 1 |
| PK/PD Model Based Dosing of Digoxin in Infants with Single Ventricle Heart Disease | 1 |
| Macitentan Dose 3 | 1 |
| Colchicines | 1 |
Showing 5 of 12 interventions.
These are the names sponsors entered on ClinicalTrials.gov that we have not matched to a single molecule. Some are drugs under a brand or code name; others are procedures, doses or arm labels.
Which serious adverse events do Univentricular Heart trials report? (10)
Shown in this order: most subjects affected first. Subjects affected summed across trials, a cross-trial signal, not a rate.
| Adverse event | Subjects affected | Trials |
|---|---|---|
| Cardiac disorders - Other specify | 26 | 1 |
| Respiratory, thoracic and mediastinal disorders - Other specify | 17 | 1 |
| Hypoxia | 15 | 2 |
| Gastrointestinal disorders - Other specify | 8 | 1 |
| Infections and infestations - Other specify | 7 | 1 |
Showing 5 of 10 adverse events.
Which publications cover Univentricular Heart? (14)
Shown in this order: major-topic papers first, then newest, then most linked to trials.
| Publication | Journal | Year | Major topic |
|---|---|---|---|
| Experience with SGLT2 Inhibitors in Patients with Single Ventricle Congenital Heart Disease and Fontan Circulatory Failure. | Pediatric cardiology | 2025 | Yes |
| Systolic performance of the single ventricle, exercise capacity, and endothelial function in pediatric Fontan patients. | American heart journal | 2025 | Yes |
| Long-Term Survival After Single-Ventricle Palliation: A Swedish Nationwide Cohort Study. | Journal of the American Heart Association | 2024 | Yes |
| Examining the Real-Life Journey of Individuals and Families Affected by Single-Ventricle Congenital Heart Disease. | Journal of the American Heart Association | 2023 | Yes |
| Correlation between three-dimensional echocardiography and cardiopulmonary fitness in patients with univentricular heart: A cross-sectional multicentre prospective study. | Archives of cardiovascular diseases | 2023 | Yes |
Showing 5 of 14 publications.
Prevalence (6)
Shown in this order: jurisdiction, then disease name. Orphanet observation for the mapped ORPHA concept; the mapping relation column says whether that concept is exactly this condition or broader or narrower.
| Orphanet disease | Type | Class | Geography | Jurisdiction | Mapping relation |
|---|---|---|---|---|---|
| Univentricular heart | Point prevalence | Unknown | Worldwide | Not stated | Exact |
| Univentricular heart | Prevalence at birth | 1-9 / 100 000 | Worldwide | Not stated | Unspecified |
| Univentricular heart | Point prevalence | Unknown | Worldwide | Not stated | Exact |
| Univentricular heart | Point prevalence | Unknown | Worldwide | Not stated | Unspecified |
| Univentricular heart | Prevalence at birth | 1-9 / 100 000 | Worldwide | Not stated | Exact |
Showing 5 of 6 prevalence observations.
Rare-disease identity (2)
Shown in this order: exact, broader, narrower, other.
| Orphanet disease | ORPHA code | Relation | Source |
|---|---|---|---|
| Univentricular heart | 1464 | Exact | Orphanet Rare Disease Ontology (ORDO) |
| Univentricular heart | 1464 | Exact | Orphadata Science knowledge files, Product 1 |
Not on this page
Not measured: delivery record.
Checked, with nothing recorded for this condition: sub-conditions in mesh.