Condition (MeSH)
Undiagnosed Diseases
ClinicalTrials.gov lists 20 trials for Undiagnosed Diseases or a narrower condition beneath it. National Human Genome Research Institute (NHGRI) has the most among industry and government lead sponsors, with 6.
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Trials per phase
20 of the 20 trials are tagged with Undiagnosed Diseases itself; the rest are tagged with a narrower condition beneath it.
When did Undiagnosed Diseases trials start? (12)
Shown in this order: most recent first, 1990 onwards. 2026 is partial: trials registered with a 2026 start date so far, not a full year.
Trials over time, by phase
- Not applicable
- Observational
Top of scale: 3
Trials registered with a start date in each year, 1990 onward, stacked by phase (complete years only; the current partial year is in the table's notes). The table below lists the same counts, most recent years first.
| Year | Trials started |
|---|---|
| 2026 (partial year) | 4 |
| 2024 | 1 |
| 2023 | 1 |
| 2022 | 2 |
| 2021 | 3 |
| 2020 | 1 |
| 2019 | 1 |
| 2018 | 2 |
| 2016 | 1 |
| 2015 | 2 |
Showing 10 of 12 earlier years.
No forecast is made for this condition: it averages 1.4 trial starts a year over the five years to September, under the 5 a year the method needs.
Recruitment duration, a model prediction: 1 trial still running at the 2026-10-09 snapshot, fewer than the 5 needed for a median. Source: ClinicalTrials.gov / AACT (CTTI), public domain.
What phase are Undiagnosed Diseases trials in? (2)
Shown in this order: phase order.
Show the trials by phase as a table
| Phase | Trials |
|---|---|
| Not applicable | 3 |
| Observational | 17 |
How many Undiagnosed Diseases trials are recruiting? (6)
Shown in this order: the order a trial moves through, from not yet recruiting to unknown.
| Status | Trials |
|---|---|
| Not yet recruiting | 1 |
| Recruiting | 8 |
| Enrolling by invitation | 4 |
| Active, not recruiting | 1 |
| Completed | 5 |
Showing 5 of 6 statuses.
Status as registered on ClinicalTrials.gov. Each trial is counted once.
Which lead sponsors run the most Undiagnosed Diseases trials? (3)
Shown in this order: most trials first. Lead sponsors the registry classes as industry, NIH, US federal, other government or network. A hospital or university the registry files as government can appear here. Sponsors it classes as academic or other are shown on the full page, because that class cannot separate an institution from a named investigator.
| Sponsor | Trials |
|---|---|
| National Human Genome Research Institute (NHGRI) | 6 |
| National Heart, Lung, and Blood Institute (NHLBI) | 2 |
| Glyconics Ltd | 1 |
Which publications cover Undiagnosed Diseases? (34)
Shown in this order: major-topic papers first, then newest, then most linked to trials.
| Publication | Journal | Year | Major topic |
|---|---|---|---|
| A concurrent dual analysis of genomic data augments diagnoses: Experiences of 2 clinical sites in the Undiagnosed Diseases Network. | Genetics in medicine : official journal of the American College of Medical Genetics | 2023 | Yes |
| Continuing a search for a diagnosis: the impact of adolescence and family dynamics. | Orphanet journal of rare diseases | 2023 | Yes |
| Undiagnosed diseases: Needs and opportunities in 20 countries participating in the Undiagnosed Diseases Network International. | Frontiers in public health | 2023 | Yes |
| Unmet needs in countries participating in the undiagnosed diseases network international: an international survey considering national health care and economic indicators. | Frontiers in public health | 2023 | Yes |
| Risks and benefits of anesthesia for combined pediatric procedures in the NIH undiagnosed diseases program. | Molecular genetics and metabolism | 2023 | Yes |
Showing 5 of 34 publications.
Not on this page
Not measured: delivery record.
Checked, with nothing recorded for this condition: drugs tested, serious adverse events in this condition's trials, prevalence, rare-disease identity, and sub-conditions in mesh.