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Condition (MeSH)

Squamous Intraepithelial Lesions

ClinicalTrials.gov lists 97 trials for Squamous Intraepithelial Lesions or a narrower condition beneath it. AIDS Malignancy Consortium has the most among industry and government lead sponsors, with 8.

MeSH D000081483 Pathological Conditions, Signs and Symptoms C23
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Phase 1 Phase 1 10 Phase 2 Phase 2 25 Phase 2/3 Phase 2/3 1 Phase 3 Phase 3 6 Phase 4 Phase 4 4 Not applicable Not applicable 22 Observational Observational 29 Phase 1 Phase 1 10 Phase 2 Phase 2 25 Phase 2/3 Phase 2/3 1 Phase 3 Phase 3 6 Phase 4 Phase 4 4 Not applicable Not applicable 22 Observational Observational 29

Trials per phase (log scale)

92 of the 97 trials are tagged with Squamous Intraepithelial Lesions itself; the rest are tagged with a narrower condition beneath it.

Get the Squamous Intraepithelial Lesions report as a PDF

The PDF carries up to 50 rows of each section, where the page shows the first few, with the sources listed. Enter a work email and confirm it from the message we send, and the report follows by email.

When did Squamous Intraepithelial Lesions trials start? (23)

Shown in this order: most recent first, 1990 onwards. 2026 is partial: trials registered with a 2026 start date so far, not a full year. 1 trial is registered to start in 2027 or later, and not listed here.

Trials over time, by phase

  • Phase 1
  • Phase 2
  • Phase 2/3
  • Phase 3
  • Phase 4
  • Not applicable
  • Observational

Top of scale: 10

1999: 1 trials (Observational 1) 2003: 1 trials (Phase 1 1) 2004: 1 trials (Phase 2 1) 2006: 2 trials (Not applicable 1, Phase 2 1) 2007: 7 trials (Observational 1, Not applicable 1, Phase 2 5) 2008: 1 trials (Observational 1) 2009: 1 trials (Phase 4 1) 2010: 2 trials (Not applicable 2) 2011: 1 trials (Phase 3 1) 2013: 1 trials (Phase 2 1) 2014: 3 trials (Not applicable 2, Phase 3 1) 2015: 5 trials (Observational 1, Not applicable 1, Phase 3 1, Phase 2 2) 2016: 4 trials (Observational 3, Phase 2 1) 2017: 3 trials (Phase 3 1, Phase 2 1, Phase 1 1) 2018: 7 trials (Observational 1, Phase 2 2, Phase 1 4) 2019: 6 trials (Observational 4, Not applicable 1, Phase 3 1) 2020: 6 trials (Observational 3, Not applicable 3) 2021: 7 trials (Observational 6, Phase 2 1) 2022: 5 trials (Observational 3, Phase 4 1, Phase 2/3 1) 2023: 5 trials (Observational 2, Not applicable 1, Phase 4 1, Phase 2 1) 2024: 10 trials (Observational 3, Not applicable 3, Phase 4 1, Phase 2 2, Phase 1 1) 2025: 4 trials (Not applicable 1, Phase 2 1, Phase 1 2)

Trials registered with a start date in each year, 1990 onward, stacked by phase (complete years only; the current partial year is in the table's notes). The table below lists the same counts, most recent years first.

Trials started per year
Year Trials started
2026 (partial year) 12
2025 4
2024 10
2023 5
2022 5
2021 7
2020 6
2019 6
2018 7
2017 3

Forecast of the full-year count, planned starts included, not rows of this table: about 13 trials starting in 2026 and about 8 in 2027, the average of the 24 months through September, counted as registered and carried forward. The rows of this table count trials registered so far with a start date in the year, planned starts included; the forecast looks ahead to the count for the whole year, so it is not the same measure. In backtests on conditions of this size, forecasts made part-way through the year were typically off by about 28 percent and ran about 20 percent low against the count later registered; forecasts made before the year began were off by about 39 percent and ran about 37 percent low against the count later registered. These figures rest on a few years of history (target years from 2018 to 2025, varying by figure), place each condition as it is mapped today rather than as it was then, and score against a count for the newest year that was still being revised. Only condition series were scored.

Prediction, not a registry value: median of 36 months from start to primary completion across 12 trials still running at the 2026-10-09 snapshot; registered median of 25 months across 48 trials with a primary completion typed Actual. Source: ClinicalTrials.gov / AACT (CTTI), public domain.

What phase are Squamous Intraepithelial Lesions trials in? (7)

Shown in this order: phase order.

Show the trials by phase as a table
Trials by phase
Phase Trials
Phase 1 10
Phase 2 25
Phase 2/3 1
Phase 3 6
Phase 4 4
Not applicable 22
Observational 29

How many Squamous Intraepithelial Lesions trials are recruiting? (8)

Shown in this order: the order a trial moves through, from not yet recruiting to unknown.

Trials by recruitment status
Status Trials
Not yet recruiting 11
Recruiting 14
Enrolling by invitation 1
Active, not recruiting 3
Completed 40

Status as registered on ClinicalTrials.gov. Each trial is counted once.

Which lead sponsors run the most Squamous Intraepithelial Lesions trials? (7)

Shown in this order: most trials first. Lead sponsors the registry classes as industry, NIH, US federal, other government or network. A hospital or university the registry files as government can appear here. Sponsors it classes as academic or other are shown on the full page, because that class cannot separate an institution from a named investigator.

Lead sponsors
Sponsor Trials
AIDS Malignancy Consortium 8
Antiva Biosciences 4
Inovio Pharmaceuticals 3
National Cancer Institute (NCI) 3
Newish Biotech (Wuxi) Co., Ltd. 3

Which drugs are being tested for Squamous Intraepithelial Lesions? (2)

Shown in this order: most trials first. One row per drug, matched to a single molecule under all its names, ranked by number of trials.

Drugs tested
Drug Trials
VGX 3100 3
Cidofovir 2

Interventions as named in the registry (13)

Shown in this order: most trials first.

Interventions as named in the registry
Drug Trials
Imiquimod 5% 3
NWRD08 administered by electroporation 2
Biopsy 2
Fluorouracile 2
Nonavalent HPV vaccine 2

These are the names sponsors entered on ClinicalTrials.gov that we have not matched to a single molecule. Some are drugs under a brand or code name; others are procedures, doses or arm labels.

Which serious adverse events do Squamous Intraepithelial Lesions trials report? (10)

Shown in this order: most subjects affected first. Subjects affected summed across trials, a cross-trial signal, not a rate.

Serious adverse events in this condition's trials
Adverse event Subjects affected Trials
Neoplasms 112 1
Infections and Infestations, other 58 1
Lung Infection 58 1
Skin Infection 37 1
Sepsis 28 1

Which publications cover Squamous Intraepithelial Lesions? (29)

Shown in this order: major-topic papers first, then newest, then most linked to trials.

Sub-conditions in MeSH (1)

MeSH descendants one level down with at least one trial, most trials first.

Not on this page

Not measured: delivery record.

Checked, with nothing recorded for this condition: prevalence and rare-disease identity.

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