Condition (MeSH)
Prolonged Grief Disorder
ClinicalTrials.gov lists 39 trials for Prolonged Grief Disorder or a narrower condition beneath it.
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Trials per phase (log scale)
39 of the 39 trials are tagged with Prolonged Grief Disorder itself; the rest are tagged with a narrower condition beneath it.
When did Prolonged Grief Disorder trials start? (16)
Shown in this order: most recent first, 1990 onwards. 2026 is partial: trials registered with a 2026 start date so far, not a full year. 1 trial is registered to start in 2027 or later, and not listed here.
Trials over time, by phase
- Phase 1
- Phase 4
- Not applicable
- Observational
Top of scale: 9
Trials registered with a start date in each year, 1990 onward, stacked by phase (complete years only; the current partial year is in the table's notes). The table below lists the same counts, most recent years first.
| Year | Trials started |
|---|---|
| 2026 (partial year) | 5 |
| 2025 | 9 |
| 2024 | 2 |
| 2023 | 2 |
| 2022 | 2 |
| 2021 | 8 |
| 2020 | 1 |
| 2019 | 1 |
| 2018 | 1 |
| 2015 | 1 |
Showing 10 of 16 earlier years.
No forecast is made for this condition: it averages 4.2 trial starts a year over the five years to September, under the 5 a year the method needs.
Prediction, not a registry value: median of 23 months from start to primary completion across 11 trials still running at the 2026-10-09 snapshot; registered median of 16 months across 17 trials with a primary completion typed Actual. Source: ClinicalTrials.gov / AACT (CTTI), public domain.
What phase are Prolonged Grief Disorder trials in? (5)
Shown in this order: phase order.
Show the trials by phase as a table
| Phase | Trials |
|---|---|
| Phase 1 | 3 |
| Phase 2/3 | 1 |
| Phase 4 | 1 |
| Not applicable | 31 |
| Observational | 3 |
How many Prolonged Grief Disorder trials are recruiting? (8)
Shown in this order: the order a trial moves through, from not yet recruiting to unknown.
| Status | Trials |
|---|---|
| Not yet recruiting | 4 |
| Recruiting | 8 |
| Enrolling by invitation | 1 |
| Active, not recruiting | 2 |
| Completed | 15 |
Showing 5 of 8 statuses.
Status as registered on ClinicalTrials.gov. Each trial is counted once.
Which drugs are being tested for Prolonged Grief Disorder? (1)
Shown in this order: most trials first. One row per drug, matched to a single molecule under all its names, ranked by number of trials.
| Drug | Trials |
|---|---|
| DEXMEDETOMIDINE | 1 |
Interventions as named in the registry (6)
Shown in this order: most trials first.
| Drug | Trials |
|---|---|
| IM Oxytocin | 1 |
| Standard Treatment | 1 |
| IM naltrexone | 1 |
| Psilocybin 25 mg | 1 |
| Treatment As Usual | 1 |
Showing 5 of 6 interventions.
These are the names sponsors entered on ClinicalTrials.gov that we have not matched to a single molecule. Some are drugs under a brand or code name; others are procedures, doses or arm labels.
Which serious adverse events do Prolonged Grief Disorder trials report? (1)
Shown in this order: most subjects affected first. Subjects affected summed across trials, a cross-trial signal, not a rate.
| Adverse event | Subjects affected | Trials |
|---|---|---|
| Serious Adverse Event | 1 | 1 |
Which publications cover Prolonged Grief Disorder? (8)
Shown in this order: major-topic papers first, then newest, then most linked to trials.
| Publication | Journal | Year | Major topic |
|---|---|---|---|
| Prolonged grief disorder. | Lancet (London, England) | 2025 | Yes |
| Change in avoidance and negative grief-related cognitions mediates treatment outcome in older adults with prolonged grief disorder. | Psychotherapy research : journal of the Society for Psychotherapy Research | 2022 | Yes |
| Peritraumatic distress predicts prolonged grief disorder symptom severity after the death of a parent in children and adolescents. | European journal of psychotraumatology | 2021 | Yes |
| DSM-5-TR prolonged grief disorder and DSM-5 posttraumatic stress disorder are related, yet distinct: confirmatory factor analyses in traumatically bereaved people. | European journal of psychotraumatology | 2021 | Yes |
| Do early symptoms of prolonged grief disorder lead to symptoms of posttraumatic stress disorder and depression? A longitudinal register-based study of the two first years of bereavement. | Journal of psychopathology and clinical science | 2023 | No |
Showing 5 of 8 publications.
Not on this page
Not measured: delivery record.
Checked, with nothing recorded for this condition: lead sponsors, prevalence, rare-disease identity, and sub-conditions in mesh.