Condition (MeSH)
Limbal Stem Cell Deficiency
ClinicalTrials.gov lists 35 trials for Limbal Stem Cell Deficiency or a narrower condition beneath it.
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Trials per phase
35 of the 35 trials are tagged with Limbal Stem Cell Deficiency itself; the rest are tagged with a narrower condition beneath it.
When did Limbal Stem Cell Deficiency trials start? (19)
Shown in this order: most recent first, 1990 onwards. 2026 is partial: trials registered with a 2026 start date so far, not a full year.
Trials over time, by phase
- Phase 1
- Phase 1/2
- Phase 2
- Not applicable
- Observational
- Expanded access
Top of scale: 4
Trials registered with a start date in each year, 1990 onward, stacked by phase (complete years only; the current partial year is in the table's notes). The table below lists the same counts, most recent years first.
| Year | Trials started |
|---|---|
| 2026 (partial year) | 2 |
| 2025 | 3 |
| 2024 | 3 |
| 2023 | 1 |
| 2022 | 1 |
| 2021 | 1 |
| 2020 | 2 |
| 2019 | 3 |
| 2018 | 1 |
| 2017 | 3 |
Showing 10 of 19 earlier years.
No forecast is made for this condition: it averages 2.0 trial starts a year over the five years to September, under the 5 a year the method needs.
Prediction, not a registry value: median of 30 months from start to primary completion across 6 trials still running at the 2026-10-09 snapshot; registered median of 24 months across 13 trials with a primary completion typed Actual. Source: ClinicalTrials.gov / AACT (CTTI), public domain.
What phase are Limbal Stem Cell Deficiency trials in? (7)
Shown in this order: phase order.
Show the trials by phase as a table
| Phase | Trials |
|---|---|
| Phase 1 | 5 |
| Phase 1/2 | 6 |
| Phase 2 | 2 |
| Phase 3 | 1 |
| Not applicable | 8 |
| Observational | 11 |
| Expanded access | 2 |
How many Limbal Stem Cell Deficiency trials are recruiting? (8)
Shown in this order: the order a trial moves through, from not yet recruiting to unknown.
| Status | Trials |
|---|---|
| Not yet recruiting | 2 |
| Recruiting | 7 |
| Active, not recruiting | 1 |
| Available | 2 |
| Completed | 13 |
Showing 5 of 8 statuses.
Status as registered on ClinicalTrials.gov. Each trial is counted once.
Which lead sponsors run the most Limbal Stem Cell Deficiency trials? (4)
Shown in this order: most trials first. Lead sponsors the registry classes as industry, NIH, US federal, other government or network. A hospital or university the registry files as government can appear here. Sponsors it classes as academic or other are shown on the full page, because that class cannot separate an institution from a named investigator.
| Sponsor | Trials |
|---|---|
| Claris Biotherapeutics, Inc. | 2 |
| Royan Institute | 2 |
| BRIM Biotechnology Inc. | 1 |
| CellSeed France S.A.R.L. | 1 |
Interventions as named in the registry (13)
Shown in this order: most trials first.
| Drug | Trials |
|---|---|
| cultivated oral mucosal epithelial sheet transplantation | 1 |
| Allogeneic Bone-Marrow Derived Mesenchymal Stromal Cells Secretome | 1 |
| Vehicle Control | 1 |
| Mucosal cell sheet transplantation | 1 |
| Amniotic Membrane Extract Eye Drop | 1 |
Showing 5 of 13 interventions.
These are the names sponsors entered on ClinicalTrials.gov that we have not matched to a single molecule. Some are drugs under a brand or code name; others are procedures, doses or arm labels.
Which serious adverse events do Limbal Stem Cell Deficiency trials report? (1)
Shown in this order: most subjects affected first. Subjects affected summed across trials, a cross-trial signal, not a rate.
| Adverse event | Subjects affected | Trials |
|---|---|---|
| Vomiting | 1 | 1 |
Which publications cover Limbal Stem Cell Deficiency? (1)
Shown in this order: major-topic papers first, then newest, then most linked to trials.
| Publication | Journal | Year | Major topic |
|---|---|---|---|
| Long-Term Effects of Adipose-Derived Stem Cells for the Treatment of Bilateral Limbal Stem Cell Deficiency. | Current eye research | 2024 | Yes |
Prevalence (2)
Shown in this order: jurisdiction, then disease name. Orphanet observation for the mapped ORPHA concept; the mapping relation column says whether that concept is exactly this condition or broader or narrower.
| Orphanet disease | Type | Class | Geography | Jurisdiction | Mapping relation |
|---|---|---|---|---|---|
| Limbal stem cell deficiency | Point prevalence | 1-5 / 10 000 | Europe | Not stated | Exact |
| Limbal stem cell deficiency | Point prevalence | 1-5 / 10 000 | Europe | Not stated | Exact |
Rare-disease identity (2)
Shown in this order: exact, broader, narrower, other.
| Orphanet disease | ORPHA code | Relation | Source |
|---|---|---|---|
| Limbal stem cell deficiency | 171673 | Exact | Orphanet Rare Disease Ontology (ORDO) |
| Limbal stem cell deficiency | 171673 | Exact | Orphadata Science knowledge files, Product 1 |
Not on this page
Not measured: delivery record.
Checked, with nothing recorded for this condition: sub-conditions in mesh.