Condition (MeSH)
Acidosis, Lactic
ClinicalTrials.gov lists 47 trials for Acidosis, Lactic or a narrower condition beneath it. Sangart has the most among industry and government lead sponsors, with 3.
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Trials per phase
47 of the 47 trials are tagged with Acidosis, Lactic itself; the rest are tagged with a narrower condition beneath it.
When did Acidosis, Lactic trials start? (22)
Shown in this order: most recent first, 1990 onwards. 2026 is partial: trials registered with a 2026 start date so far, not a full year. 1 trial is registered to start in 2027 or later, and not listed here.
Trials over time, by phase
- Phase 1
- Phase 2
- Phase 2/3
- Phase 3
- Phase 4
- Not applicable
- Observational
Top of scale: 4
Trials registered with a start date in each year, 1990 onward, stacked by phase (complete years only; the current partial year is in the table's notes). The table below lists the same counts, most recent years first.
| Year | Trials started |
|---|---|
| 2025 | 2 |
| 2024 | 3 |
| 2023 | 2 |
| 2021 | 1 |
| 2020 | 1 |
| 2018 | 1 |
| 2017 | 2 |
| 2016 | 4 |
| 2015 | 3 |
| 2014 | 1 |
Showing 10 of 22 earlier years.
No forecast is made for this condition: it averages 1.4 trial starts a year over the five years to September, under the 5 a year the method needs.
Recruitment duration, a model prediction: 1 trial still running at the 2026-10-09 snapshot, fewer than the 5 needed for a median. Source: ClinicalTrials.gov / AACT (CTTI), public domain.
What phase are Acidosis, Lactic trials in? (8)
Shown in this order: phase order.
Show the trials by phase as a table
| Phase | Trials |
|---|---|
| Phase 1 | 1 |
| Phase 1/2 | 1 |
| Phase 2 | 11 |
| Phase 2/3 | 2 |
| Phase 3 | 1 |
| Phase 4 | 5 |
| Not applicable | 9 |
| Observational | 17 |
How many Acidosis, Lactic trials are recruiting? (8)
Shown in this order: the order a trial moves through, from not yet recruiting to unknown.
| Status | Trials |
|---|---|
| Not yet recruiting | 1 |
| Recruiting | 3 |
| Enrolling by invitation | 1 |
| Active, not recruiting | 1 |
| Completed | 26 |
Showing 5 of 8 statuses.
Status as registered on ClinicalTrials.gov. Each trial is counted once.
Which lead sponsors run the most Acidosis, Lactic trials? (4)
Shown in this order: most trials first. Lead sponsors the registry classes as industry, NIH, US federal, other government or network. A hospital or university the registry files as government can appear here. Sponsors it classes as academic or other are shown on the full page, because that class cannot separate an institution from a named investigator.
| Sponsor | Trials |
|---|---|
| Sangart | 3 |
| Tisento Therapeutics | 2 |
| Amgen | 1 |
| Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) | 1 |
Which drugs are being tested for Acidosis, Lactic? (4)
Shown in this order: most trials first. One row per drug, matched to a single molecule under all its names, ranked by number of trials.
| Drug | Trials |
|---|---|
| Dichloroacetate | 5 |
| IW-6463 | 2 |
| Thiamine | 2 |
| (Cystagon) Cysteamine Bitartrate | 1 |
Interventions as named in the registry (11)
Shown in this order: most trials first.
| Drug | Trials |
|---|---|
| 1% Metformin | 4 |
| MP4OX | 3 |
| Blood Transfusion | 1 |
| Riboflavin and Thiamine (Supplementation) | 1 |
| cofactor supplementation (thiamine, riboflavin, L-carnitine) | 1 |
Showing 5 of 11 interventions.
These are the names sponsors entered on ClinicalTrials.gov that we have not matched to a single molecule. Some are drugs under a brand or code name; others are procedures, doses or arm labels.
Which serious adverse events do Acidosis, Lactic trials report? (10)
Shown in this order: most subjects affected first. Subjects affected summed across trials, a cross-trial signal, not a rate.
| Adverse event | Subjects affected | Trials |
|---|---|---|
| Convulsion | 2 | 1 |
| Vomiting | 2 | 1 |
| Acute respiratory failure | 1 | 1 |
| Ataxia | 1 | 1 |
| Blepharospasm | 1 | 1 |
Showing 5 of 10 adverse events.
Which publications cover Acidosis, Lactic? (107)
Shown in this order: major-topic papers first, then newest, then most linked to trials.
| Publication | Journal | Year | Major topic |
|---|---|---|---|
| Association between lactic acidosis and multiple organ dysfunction syndrome after cardiopulmonary bypass. | PeerJ | 2024 | Yes |
| High-dose oral glutamine supplementation reduces elevated glutamate levels in cerebrospinal fluid in patients with mitochondrial encephalomyopathy, lactic acidosis and stroke-like episodes syndrome. | European journal of neurology | 2023 | Yes |
| Safety of metformin continuation in diabetic patients undergoing invasive coronary angiography: the NO-STOP single arm trial. | Cardiovascular diabetology | 2023 | Yes |
| Metformin misuse in chronic kidney disease. | Diabetes & metabolism | 2020 | Yes |
| A case of malignant hyperlactaemic acidosis appearing upon treatment with the mono-carboxylase transporter 1 inhibitor AZD3965. | British journal of cancer | 2020 | Yes |
Showing 5 of 107 publications.
Not on this page
Not measured: delivery record.
Checked, with nothing recorded for this condition: prevalence, rare-disease identity, and sub-conditions in mesh.