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Condition (MeSH)

Alcoholism

ClinicalTrials.gov lists 1,663 trials for Alcoholism or a narrower condition beneath it. National Institute on Alcohol Abuse and Alcoholism (NIAAA) has the most among industry and government lead sponsors, with 70.

MeSH D000437 Chemically-Induced Disorders C25 F03
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Phase 1 Phase 1 123 Phase 1/2 Phase 1/2 42 Phase 2 Phase 2 304 Phase 2/3 Phase 2/3 37 Phase 3 Phase 3 86 Phase 4 Phase 4 125 Not applicable Not applicable 757 Observational Observational 189 Phase 1 Phase 1 123 Phase 1/2 Phase 1/2 42 Phase 2 Phase 2 304 Phase 2/3 Phase 2/3 37 Phase 3 Phase 3 86 Phase 4 Phase 4 125 Not applicable Not applicable 757 Observational Observational 189

Trials per phase (log scale)

1,663 of the 1,663 trials are tagged with Alcoholism itself; the rest are tagged with a narrower condition beneath it.

Get the Alcoholism report as a PDF

The PDF carries up to 50 rows of each section, where the page shows the first few, with the sources listed. Enter a work email and confirm it from the message we send, and the report follows by email.

When did Alcoholism trials start? (33)

Shown in this order: most recent first, 1990 onwards. 2026 is partial: trials registered with a 2026 start date so far, not a full year. 15 trials are registered to start in 2027 or later, and not listed here.

Trials over time, by phase

  • Phase 1
  • Phase 1/2
  • Phase 2
  • Phase 2/3
  • Phase 3
  • Phase 4
  • Not applicable
  • Observational

Top of scale: 105

1992: 2 trials (Observational 1, Phase 4 1) 1995: 1 trials (Phase 4 1) 1996: 1 trials (Observational 1) 1997: 6 trials (Observational 1, Not applicable 1, Phase 4 3, Phase 3 1) 1998: 6 trials (Observational 2, Phase 4 1, Phase 3 2, Phase 2 1) 1999: 8 trials (Not applicable 2, Phase 4 3, Phase 2/3 1, Phase 2 1, Phase 1 1) 2000: 7 trials (Phase 4 5, Phase 2 2) 2001: 16 trials (Observational 2, Not applicable 4, Phase 4 2, Phase 3 3, Phase 2 5) 2002: 18 trials (Observational 3, Not applicable 3, Phase 4 6, Phase 3 3, Phase 2 2, Phase 1 1) 2003: 32 trials (Observational 2, Not applicable 3, Phase 4 8, Phase 3 6, Phase 2/3 2, Phase 2 8, Phase 1/2 1, Phase 1 2) 2004: 38 trials (Observational 6, Not applicable 7, Phase 4 4, Phase 3 6, Phase 2/3 1, Phase 2 13, Phase 1/2 1) 2005: 31 trials (Observational 5, Not applicable 6, Phase 4 6, Phase 3 2, Phase 2/3 2, Phase 2 9, Phase 1/2 1) 2006: 42 trials (Observational 2, Not applicable 11, Phase 4 10, Phase 3 6, Phase 2 9, Phase 1/2 2, Phase 1 2) 2007: 47 trials (Observational 5, Not applicable 12, Phase 4 10, Phase 3 8, Phase 2/3 2, Phase 2 6, Phase 1/2 1, Phase 1 3) 2008: 47 trials (Observational 5, Not applicable 14, Phase 4 4, Phase 3 5, Phase 2/3 2, Phase 2 7, Phase 1/2 1, Phase 1 9) 2009: 46 trials (Observational 3, Not applicable 13, Phase 4 5, Phase 3 3, Phase 2/3 1, Phase 2 17, Phase 1/2 1, Phase 1 3) 2010: 56 trials (Observational 5, Not applicable 19, Phase 4 8, Phase 3 1, Phase 2/3 2, Phase 2 17, Phase 1/2 1, Phase 1 3) 2011: 48 trials (Observational 4, Not applicable 18, Phase 4 4, Phase 3 3, Phase 2/3 4, Phase 2 6, Phase 1/2 2, Phase 1 7) 2012: 48 trials (Observational 8, Not applicable 20, Phase 4 1, Phase 3 3, Phase 2/3 3, Phase 2 9, Phase 1/2 1, Phase 1 3) 2013: 50 trials (Observational 8, Not applicable 22, Phase 4 3, Phase 3 2, Phase 2 11, Phase 1/2 1, Phase 1 3) 2014: 69 trials (Observational 14, Not applicable 26, Phase 4 6, Phase 3 4, Phase 2 9, Phase 1/2 4, Phase 1 6) 2015: 70 trials (Observational 8, Not applicable 41, Phase 4 2, Phase 3 3, Phase 2/3 1, Phase 2 8, Phase 1/2 1, Phase 1 6) 2016: 64 trials (Observational 4, Not applicable 29, Phase 4 5, Phase 3 6, Phase 2/3 1, Phase 2 12, Phase 1/2 1, Phase 1 6) 2017: 69 trials (Observational 9, Not applicable 31, Phase 4 6, Phase 3 5, Phase 2/3 1, Phase 2 10, Phase 1/2 4, Phase 1 3) 2018: 71 trials (Observational 6, Not applicable 40, Phase 4 1, Phase 3 2, Phase 2/3 1, Phase 2 10, Phase 1/2 2, Phase 1 9) 2019: 100 trials (Observational 13, Not applicable 57, Phase 4 1, Phase 2/3 1, Phase 2 19, Phase 1/2 5, Phase 1 4) 2020: 76 trials (Observational 14, Not applicable 45, Phase 4 1, Phase 3 2, Phase 2/3 1, Phase 2 5, Phase 1/2 1, Phase 1 7) 2021: 90 trials (Observational 8, Not applicable 53, Phase 2/3 3, Phase 2 17, Phase 1/2 2, Phase 1 7) 2022: 86 trials (Observational 7, Not applicable 53, Phase 4 4, Phase 2/3 1, Phase 2 15, Phase 1/2 2, Phase 1 4) 2023: 98 trials (Observational 8, Not applicable 61, Phase 4 3, Phase 3 1, Phase 2/3 2, Phase 2 17, Phase 1 6) 2024: 105 trials (Observational 13, Not applicable 60, Phase 4 1, Phase 3 2, Phase 2/3 1, Phase 2 15, Phase 1/2 2, Phase 1 11) 2025: 90 trials (Observational 11, Not applicable 47, Phase 4 1, Phase 3 3, Phase 2/3 1, Phase 2 15, Phase 1/2 4, Phase 1 8)

Trials registered with a start date in each year, 1990 onward, stacked by phase (complete years only; the current partial year is in the table's notes). The table below lists the same counts, most recent years first.

Trials started per year
Year Trials started
2026 (partial year) 94
2025 90
2024 105
2023 98
2022 86
2021 90
2020 76
2019 100
2018 71
2017 69

Forecast of the full-year count, planned starts included, not rows of this table: about 110 trials starting in 2026 and about 95 in 2027, the average of the 24 months through September, counted as registered and carried forward, with about 0.7 times the starts already registered for the rest of 2026 added. The rows of this table count trials registered so far with a start date in the year, planned starts included; the forecast looks ahead to the count for the whole year, so it is not the same measure. In backtests on conditions of this size, forecasts made part-way through the year were typically off by about 15 percent and ran about 1 percent high against the count later registered; forecasts made before the year began were off by about 26 percent and ran about 20 percent low against the count later registered. The part-way figures are from forecasts that used a multiple fitted only on earlier years. These figures rest on a few years of history (target years from 2018 to 2025, varying by figure), place each condition as it is mapped today rather than as it was then, and score against a count for the newest year that was still being revised. Only condition series were scored.

Prediction, not a registry value: median of 36 months from start to primary completion across 196 trials still running at the 2026-10-09 snapshot; registered median of 30 months across 1,080 trials with a primary completion typed Actual. Source: ClinicalTrials.gov / AACT (CTTI), public domain.

What phase are Alcoholism trials in? (8)

Shown in this order: phase order.

Show the trials by phase as a table
Trials by phase
Phase Trials
Phase 1 123
Phase 1/2 42
Phase 2 304
Phase 2/3 37
Phase 3 86
Phase 4 125
Not applicable 757
Observational 189

How many Alcoholism trials are recruiting? (9)

Shown in this order: the order a trial moves through, from not yet recruiting to unknown.

Trials by recruitment status
Status Trials
Not yet recruiting 74
Recruiting 214
Enrolling by invitation 13
Active, not recruiting 55
Completed 1,016

Status as registered on ClinicalTrials.gov. Each trial is counted once.

Which lead sponsors run the most Alcoholism trials? (2)

Shown in this order: most trials first. Lead sponsors the registry classes as industry, NIH, US federal, other government or network. A hospital or university the registry files as government can appear here. Sponsors it classes as academic or other are shown on the full page, because that class cannot separate an institution from a named investigator.

Lead sponsors
Sponsor Trials
National Institute on Alcohol Abuse and Alcoholism (NIAAA) 70
VA Office of Research and Development 47

Which drugs are being tested for Alcoholism? (3)

Shown in this order: most trials first. One row per drug, matched to a single molecule under all its names, ranked by number of trials.

Drugs tested
Drug Trials
Cannabidiol 11
Nalmefene 11
PMI-150 (intranasal ketamine) 10

Interventions as named in the registry (12)

Shown in this order: most trials first.

Interventions as named in the registry
Drug Trials
IM naltrexone 85
98% dehydrated alcohol 31
Acomprosate 25
Topiramate IR 21
Treatment As Usual 21

These are the names sponsors entered on ClinicalTrials.gov that we have not matched to a single molecule. Some are drugs under a brand or code name; others are procedures, doses or arm labels.

Which serious adverse events do Alcoholism trials report? (10)

Shown in this order: most subjects affected first. Subjects affected summed across trials, a cross-trial signal, not a rate.

Serious adverse events in this condition's trials
Adverse event Subjects affected Trials
Hospitalization 173 11
hosapitalizations 152 1
Alcoholism 84 11
Increased drinking from baseline 65 1
Suicidal ideation 29 12

Which publications cover Alcoholism? (2,285)

Shown in this order: major-topic papers first, then newest, then most linked to trials.

Not on this page

Not measured: delivery record.

Checked, with nothing recorded for this condition: prevalence, rare-disease identity, and sub-conditions in mesh.

Browse all condition evidence pages