Condition (MeSH)
Aortic Stenosis, Subvalvular
ClinicalTrials.gov lists 353 trials for Aortic Stenosis, Subvalvular or a narrower condition beneath it. Bristol-Myers Squibb has the most among industry and government lead sponsors, with 25.
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Trials per phase (log scale)
1 of the 353 trials are tagged with Aortic Stenosis, Subvalvular itself; the rest are tagged with a narrower condition beneath it.
When did Aortic Stenosis, Subvalvular trials start? (34)
Shown in this order: most recent first, 1990 onwards. 2026 is partial: trials registered with a 2026 start date so far, not a full year. 1 trial is registered to start in 2027 or later, and not listed here.
Trials over time, by phase
- Phase 1
- Phase 1/2
- Phase 2
- Phase 2/3
- Phase 3
- Phase 4
- Not applicable
- Observational
Top of scale: 33
Trials registered with a start date in each year, 1990 onward, stacked by phase (complete years only; the current partial year is in the table's notes). The table below lists the same counts, most recent years first.
| Year | Trials started |
|---|---|
| 2026 (partial year) | 30 |
| 2025 | 32 |
| 2024 | 33 |
| 2023 | 32 |
| 2022 | 19 |
| 2021 | 15 |
| 2020 | 23 |
| 2019 | 21 |
| 2018 | 18 |
| 2017 | 14 |
Showing 10 of 34 earlier years.
Forecast of the full-year count, planned starts included, not rows of this table: about 36 trials starting in 2026 and about 32 in 2027, the average of the 24 months through September, counted as registered and carried forward, with about 0.7 times the starts already registered for the rest of 2026 added. The rows of this table count trials registered so far with a start date in the year, planned starts included; the forecast looks ahead to the count for the whole year, so it is not the same measure. In backtests on conditions of this size, forecasts made part-way through the year were typically off by about 15 percent and ran about 1 percent high against the count later registered; forecasts made before the year began were off by about 26 percent and ran about 20 percent low against the count later registered. The part-way figures are from forecasts that used a multiple fitted only on earlier years. These figures rest on a few years of history (target years from 2018 to 2025, varying by figure), place each condition as it is mapped today rather than as it was then, and score against a count for the newest year that was still being revised. Only condition series were scored.
Prediction, not a registry value: median of 36 months from start to primary completion across 31 trials still running at the 2026-10-09 snapshot; registered median of 33 months across 144 trials with a primary completion typed Actual. Source: ClinicalTrials.gov / AACT (CTTI), public domain.
What phase are Aortic Stenosis, Subvalvular trials in? (8)
Shown in this order: phase order.
Show the trials by phase as a table
| Phase | Trials |
|---|---|
| Phase 1 | 18 |
| Phase 1/2 | 2 |
| Phase 2 | 34 |
| Phase 2/3 | 5 |
| Phase 3 | 21 |
| Phase 4 | 14 |
| Not applicable | 81 |
| Observational | 178 |
How many Aortic Stenosis, Subvalvular trials are recruiting? (8)
Shown in this order: the order a trial moves through, from not yet recruiting to unknown.
| Status | Trials |
|---|---|
| Not yet recruiting | 20 |
| Recruiting | 65 |
| Enrolling by invitation | 11 |
| Active, not recruiting | 29 |
| Completed | 137 |
Showing 5 of 8 statuses.
Status as registered on ClinicalTrials.gov. Each trial is counted once.
Which lead sponsors run the most Aortic Stenosis, Subvalvular trials? (7)
Shown in this order: most trials first. Lead sponsors the registry classes as industry, NIH, US federal, other government or network. A hospital or university the registry files as government can appear here. Sponsors it classes as academic or other are shown on the full page, because that class cannot separate an institution from a named investigator.
| Sponsor | Trials |
|---|---|
| Bristol-Myers Squibb | 25 |
| National Heart, Lung, and Blood Institute (NHLBI) | 24 |
| China National Center for Cardiovascular Diseases | 9 |
| Meshalkin Research Institute of Pathology of Circulation | 6 |
| Shandong Suncadia Medicine Co., Ltd. | 6 |
Showing 5 of 7 sponsors.
Which drugs are being tested for Aortic Stenosis, Subvalvular? (3)
Shown in this order: most trials first. One row per drug, matched to a single molecule under all its names, ranked by number of trials.
| Drug | Trials |
|---|---|
| Aficamten | 8 |
| Perhexiline | 3 |
| .spironolactone | 2 |
Interventions as named in the registry (12)
Shown in this order: most trials first.
| Drug | Trials |
|---|---|
| Mavacamten Capsule 2 | 37 |
| HRS-1893 | 4 |
| Metoprolol XL | 4 |
| Low dose losartan | 3 |
| SR verapamil | 2 |
Showing 5 of 12 interventions.
These are the names sponsors entered on ClinicalTrials.gov that we have not matched to a single molecule. Some are drugs under a brand or code name; others are procedures, doses or arm labels.
Which serious adverse events do Aortic Stenosis, Subvalvular trials report? (10)
Shown in this order: most subjects affected first. Subjects affected summed across trials, a cross-trial signal, not a rate.
| Adverse event | Subjects affected | Trials |
|---|---|---|
| Atrial fibrillation | 38 | 7 |
| Heart Failure / CHF / Low output Failure | 26 | 1 |
| Cardiac failure | 22 | 3 |
| Hemorrhage | 22 | 1 |
| Syncope | 20 | 7 |
Showing 5 of 10 adverse events.
Which publications cover Aortic Stenosis, Subvalvular? (2)
Shown in this order: major-topic papers first, then newest, then most linked to trials.
| Publication | Journal | Year | Major topic |
|---|---|---|---|
| Correlates and causes of death in patients with severe symptomatic aortic stenosis who are not eligible to participate in a clinical trial of transcatheter aortic valve implantation. | Circulation | 2010 | Yes |
| Verapamil therapy: a new approach to pharmacologic treatment of hypertrophic cardiomyopathy. | Chest | 1980 | Yes |
Sub-conditions in MeSH (1)
MeSH descendants one level down with at least one trial, most trials first.
Not on this page
Not measured: delivery record.
Checked, with nothing recorded for this condition: prevalence and rare-disease identity.