Condition (MeSH)
Ataxia Telangiectasia
ClinicalTrials.gov lists 42 trials for Ataxia Telangiectasia or a narrower condition beneath it. Quince Therapeutics S.p.A. has the most among industry and government lead sponsors, with 4.
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Trials per phase
42 of the 42 trials are tagged with Ataxia Telangiectasia itself; the rest are tagged with a narrower condition beneath it.
When did Ataxia Telangiectasia trials start? (19)
Shown in this order: most recent first, 1990 onwards. 2026 is partial: trials registered with a 2026 start date so far, not a full year.
Trials over time, by phase
- Phase 1
- Phase 1/2
- Phase 2
- Phase 3
- Phase 4
- Not applicable
- Observational
Top of scale: 4
Trials registered with a start date in each year, 1990 onward, stacked by phase (complete years only; the current partial year is in the table's notes). The table below lists the same counts, most recent years first.
| Year | Trials started |
|---|---|
| 2026 (partial year) | 2 |
| 2025 | 2 |
| 2024 | 4 |
| 2023 | 1 |
| 2022 | 4 |
| 2021 | 2 |
| 2020 | 2 |
| 2019 | 4 |
| 2018 | 2 |
| 2016 | 2 |
Showing 10 of 19 earlier years.
No forecast is made for this condition: it averages 2.6 trial starts a year over the five years to September, under the 5 a year the method needs.
Recruitment duration, a model prediction: 3 trials still running at the 2026-10-09 snapshot, fewer than the 5 needed for a median. Source: ClinicalTrials.gov / AACT (CTTI), public domain.
What phase are Ataxia Telangiectasia trials in? (8)
Shown in this order: phase order.
Show the trials by phase as a table
| Phase | Trials |
|---|---|
| Phase 1 | 3 |
| Phase 1/2 | 2 |
| Phase 2 | 8 |
| Phase 3 | 5 |
| Phase 4 | 2 |
| Not applicable | 9 |
| Observational | 12 |
| Expanded access | 1 |
How many Ataxia Telangiectasia trials are recruiting? (8)
Shown in this order: the order a trial moves through, from not yet recruiting to unknown.
| Status | Trials |
|---|---|
| Not yet recruiting | 1 |
| Recruiting | 4 |
| Active, not recruiting | 3 |
| Completed | 17 |
| Approved for marketing | 1 |
Showing 5 of 8 statuses.
Status as registered on ClinicalTrials.gov. Each trial is counted once.
Which lead sponsors run the most Ataxia Telangiectasia trials? (8)
Shown in this order: most trials first. Lead sponsors the registry classes as industry, NIH, US federal, other government or network. A hospital or university the registry files as government can appear here. Sponsors it classes as academic or other are shown on the full page, because that class cannot separate an institution from a named investigator.
| Sponsor | Trials |
|---|---|
| Quince Therapeutics S.p.A. | 4 |
| IntraBio Inc | 3 |
| Sheba Medical Center | 2 |
| Bayer | 1 |
| Beijing Tide Pharmaceutical Co., Ltd | 1 |
Showing 5 of 8 sponsors.
Which drugs are being tested for Ataxia Telangiectasia? (2)
Shown in this order: most trials first. One row per drug, matched to a single molecule under all its names, ranked by number of trials.
| Drug | Trials |
|---|---|
| N-Acetyl-L-Leucine | 3 |
| Nicotinamide Riboside | 2 |
Interventions as named in the registry (13)
Shown in this order: most trials first.
| Drug | Trials |
|---|---|
| Dexamethasone/Dexamethasone acetate | 2 |
| MK0991, caspofungin acetate | 1 |
| Lumbar puncture | 1 |
| Antisense oligonucleotide targeting the ATM gene | 1 |
| TCC1727 tablet 90mg | 1 |
Showing 5 of 13 interventions.
These are the names sponsors entered on ClinicalTrials.gov that we have not matched to a single molecule. Some are drugs under a brand or code name; others are procedures, doses or arm labels.
Which serious adverse events do Ataxia Telangiectasia trials report? (10)
Shown in this order: most subjects affected first. Subjects affected summed across trials, a cross-trial signal, not a rate.
| Adverse event | Subjects affected | Trials |
|---|---|---|
| Forearm fracture | 2 | 1 |
| Lower respiratory tract infection | 2 | 2 |
| B-Cell limphoma | 1 | 1 |
| Bronchiectasis | 1 | 1 |
| Bronchospasm | 1 | 1 |
Showing 5 of 10 adverse events.
Which publications cover Ataxia Telangiectasia? (73)
Shown in this order: major-topic papers first, then newest, then most linked to trials.
| Publication | Journal | Year | Major topic |
|---|---|---|---|
| Long-Term Nicotinamide Riboside Use Improves Coordination and Eye Movements in Ataxia Telangiectasia. | Movement disorders : official journal of the Movement Disorder Society | 2024 | Yes |
| Safety and efficacy of intra-erythrocyte dexamethasone sodium phosphate in children with ataxia telangiectasia (ATTeST): a multicentre, randomised, double-blind, placebo-controlled phase 3 trial. | The Lancet. Neurology | 2024 | Yes |
| Camonsertib in DNA damage response-deficient advanced solid tumors: phase 1 trial results. | Nature medicine | 2023 | Yes |
| A framework for individualized splice-switching oligonucleotide therapy. | Nature | 2023 | Yes |
| Effects of Acetyl-DL-Leucine on Ataxia and Downbeat-Nystagmus in Six Patients With Ataxia Telangiectasia. | Journal of child neurology | 2022 | Yes |
Showing 5 of 73 publications.
Prevalence (24)
Shown in this order: jurisdiction, then disease name. Orphanet observation for the mapped ORPHA concept; the mapping relation column says whether that concept is exactly this condition or broader or narrower.
| Orphanet disease | Type | Class | Geography | Jurisdiction | Mapping relation |
|---|---|---|---|---|---|
| Ataxia-telangiectasia | Point prevalence | 1-9 / 1 000 000 | United Kingdom | GB | Exact |
| Ataxia-telangiectasia | Point prevalence | 1-9 / 1 000 000 | United Kingdom | GB | Exact |
| Ataxia-telangiectasia | Point prevalence | 1-9 / 1 000 000 | United Kingdom | GB | Unspecified |
| Ataxia-telangiectasia | Prevalence at birth | 1-9 / 100 000 | United States | US | Exact |
| Ataxia-telangiectasia | Prevalence at birth | 1-9 / 100 000 | United States | US | Exact |
Showing 5 of 24 prevalence observations.
Rare-disease identity (2)
Shown in this order: exact, broader, narrower, other.
| Orphanet disease | ORPHA code | Relation | Source |
|---|---|---|---|
| Ataxia-telangiectasia | 100 | Exact | Orphadata Science knowledge files, Product 1 |
| Ataxia-telangiectasia | 100 | Exact | Orphanet Rare Disease Ontology (ORDO) |
Not on this page
Not measured: delivery record.
Checked, with nothing recorded for this condition: sub-conditions in mesh.