Condition (MeSH)
Brain Death
ClinicalTrials.gov lists 71 trials for Brain Death or a narrower condition beneath it. Kiskunhalas Semmelweis Hospital the Teaching Hospital of the University of Szeged has the most among industry and government lead sponsors, with 2.
Search trials, drugs, companies and investigators, and follow each one to the others. Individual plan, $249/seat/mo. Card required.
Trials per phase (log scale)
71 of the 71 trials are tagged with Brain Death itself; the rest are tagged with a narrower condition beneath it.
When did Brain Death trials start? (23)
Shown in this order: most recent first, 1990 onwards. 2026 is partial: trials registered with a 2026 start date so far, not a full year.
Trials over time, by phase
- Phase 1
- Phase 1/2
- Phase 2
- Phase 2/3
- Phase 3
- Phase 4
- Not applicable
- Observational
Top of scale: 7
Trials registered with a start date in each year, 1990 onward, stacked by phase (complete years only; the current partial year is in the table's notes). The table below lists the same counts, most recent years first.
| Year | Trials started |
|---|---|
| 2026 (partial year) | 4 |
| 2025 | 1 |
| 2024 | 5 |
| 2023 | 5 |
| 2022 | 3 |
| 2021 | 2 |
| 2020 | 2 |
| 2019 | 7 |
| 2018 | 5 |
| 2017 | 7 |
Showing 10 of 23 earlier years.
No forecast is made for this condition: it averages 3.4 trial starts a year over the five years to September, under the 5 a year the method needs.
Recruitment duration, a model prediction: 1 trial still running at the 2026-10-09 snapshot, fewer than the 5 needed for a median. Source: ClinicalTrials.gov / AACT (CTTI), public domain.
What phase are Brain Death trials in? (8)
Shown in this order: phase order.
Show the trials by phase as a table
| Phase | Trials |
|---|---|
| Phase 1 | 3 |
| Phase 1/2 | 1 |
| Phase 2 | 3 |
| Phase 2/3 | 1 |
| Phase 3 | 4 |
| Phase 4 | 3 |
| Not applicable | 22 |
| Observational | 34 |
How many Brain Death trials are recruiting? (7)
Shown in this order: the order a trial moves through, from not yet recruiting to unknown.
| Status | Trials |
|---|---|
| Not yet recruiting | 4 |
| Recruiting | 4 |
| Active, not recruiting | 1 |
| Completed | 43 |
| Terminated | 7 |
Showing 5 of 7 statuses.
Status as registered on ClinicalTrials.gov. Each trial is counted once.
Which lead sponsors run the most Brain Death trials? (4)
Shown in this order: most trials first. Lead sponsors the registry classes as industry, NIH, US federal, other government or network. A hospital or university the registry files as government can appear here. Sponsors it classes as academic or other are shown on the full page, because that class cannot separate an institution from a named investigator.
| Sponsor | Trials |
|---|---|
| Kiskunhalas Semmelweis Hospital the Teaching Hospital of the University of Szeged | 2 |
| Antalya Training and Research Hospital | 1 |
| Bioquark Inc. | 1 |
| Bursa Yuksek Ihtisas Training and Research Hospital | 1 |
Which drugs are being tested for Brain Death? (2)
Shown in this order: most trials first. One row per drug, matched to a single molecule under all its names, ranked by number of trials.
| Drug | Trials |
|---|---|
| (11C) flumazenil | 1 |
| LIRAGLUTIDE | 1 |
Interventions as named in the registry (13)
Shown in this order: most trials first.
| Drug | Trials |
|---|---|
| Test Euthyrox® | 3 |
| naloxone IM | 2 |
| BQ-A Peptide Extract | 1 |
| Combination Product (sumatriptan succinate / naproxen sodium) | 1 |
| N Acetylcysteine | 1 |
Showing 5 of 13 interventions.
These are the names sponsors entered on ClinicalTrials.gov that we have not matched to a single molecule. Some are drugs under a brand or code name; others are procedures, doses or arm labels.
Which serious adverse events do Brain Death trials report? (1)
Shown in this order: most subjects affected first. Subjects affected summed across trials, a cross-trial signal, not a rate.
| Adverse event | Subjects affected | Trials |
|---|---|---|
| Cardiac arrest / donor loss | 5 | 1 |
Which publications cover Brain Death? (216)
Shown in this order: major-topic papers first, then newest, then most linked to trials.
| Publication | Journal | Year | Major topic |
|---|---|---|---|
| Identifying Variation in Intraoperative Management of Brain-Dead Organ Donors and Opportunities for Improvement: A Multicenter Perioperative Outcomes Group Analysis. | Anesthesia and analgesia | 2025 | Yes |
| Extracellular vesicles in lung donor plasma: Potential indicators of donor organ quality. | The Journal of thoracic and cardiovascular surgery | 2025 | Yes |
| Feasibility of High-Flow Oxygen Therapy in Apnea Testing for Brain Death Diagnosis. | Critical care medicine | 2025 | Yes |
| Predictors of brain death and barriers to organ donation in north African intensive care units: a multicenter prospective study on severe coma patients. | The Libyan journal of medicine | 2025 | Yes |
| Automated screening for clinically ascertained loss of cerebral functions in patients with severe brain injury-study protocol for a cluster-randomized interventional trial. | Trials | 2025 | Yes |
Showing 5 of 216 publications.
Not on this page
Not measured: delivery record.
Checked, with nothing recorded for this condition: prevalence, rare-disease identity, and sub-conditions in mesh.