Condition (MeSH)
Cardiac Output, Low
ClinicalTrials.gov lists 96 trials for Cardiac Output, Low or a narrower condition beneath it. Innogene Kalbiotech Pte. Ltd has the most among industry and government lead sponsors, with 2.
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Trials per phase (log scale)
96 of the 96 trials are tagged with Cardiac Output, Low itself; the rest are tagged with a narrower condition beneath it.
When did Cardiac Output, Low trials start? (23)
Shown in this order: most recent first, 1990 onwards. 2026 is partial: trials registered with a 2026 start date so far, not a full year.
Trials over time, by phase
- Phase 1
- Phase 1/2
- Phase 2
- Phase 2/3
- Phase 3
- Phase 4
- Not applicable
- Observational
Top of scale: 9
Trials registered with a start date in each year, 1990 onward, stacked by phase (complete years only; the current partial year is in the table's notes). The table below lists the same counts, most recent years first.
| Year | Trials started |
|---|---|
| 2026 (partial year) | 4 |
| 2025 | 3 |
| 2024 | 4 |
| 2023 | 5 |
| 2022 | 2 |
| 2021 | 9 |
| 2020 | 6 |
| 2019 | 7 |
| 2018 | 7 |
| 2017 | 4 |
Showing 10 of 23 earlier years.
No forecast is made for this condition: it averages 4.0 trial starts a year over the five years to September, under the 5 a year the method needs.
Prediction, not a registry value: median of 36 months from start to primary completion across 7 trials still running at the 2026-10-09 snapshot; registered median of 14 months across 60 trials with a primary completion typed Actual. Source: ClinicalTrials.gov / AACT (CTTI), public domain.
What phase are Cardiac Output, Low trials in? (8)
Shown in this order: phase order.
Show the trials by phase as a table
| Phase | Trials |
|---|---|
| Phase 1 | 1 |
| Phase 1/2 | 2 |
| Phase 2 | 3 |
| Phase 2/3 | 3 |
| Phase 3 | 10 |
| Phase 4 | 7 |
| Not applicable | 23 |
| Observational | 47 |
How many Cardiac Output, Low trials are recruiting? (7)
Shown in this order: the order a trial moves through, from not yet recruiting to unknown.
| Status | Trials |
|---|---|
| Not yet recruiting | 2 |
| Recruiting | 7 |
| Enrolling by invitation | 1 |
| Completed | 59 |
| Terminated | 2 |
Showing 5 of 7 statuses.
Status as registered on ClinicalTrials.gov. Each trial is counted once.
Which lead sponsors run the most Cardiac Output, Low trials? (1)
Shown in this order: most trials first. Lead sponsors the registry classes as industry, NIH, US federal, other government or network. A hospital or university the registry files as government can appear here. Sponsors it classes as academic or other are shown on the full page, because that class cannot separate an institution from a named investigator.
| Sponsor | Trials |
|---|---|
| Innogene Kalbiotech Pte. Ltd | 2 |
Which drugs are being tested for Cardiac Output, Low? (4)
Shown in this order: most trials first. One row per drug, matched to a single molecule under all its names, ranked by number of trials.
| Drug | Trials |
|---|---|
| Levosimendan | 8 |
| PHENYLEPHRINE | 2 |
| Perhexiline | 2 |
| Norepinephrine | 2 |
Interventions as named in the registry (11)
Shown in this order: most trials first.
| Drug | Trials |
|---|---|
| Inhaled Milrinone | 6 |
| Ringer Lactate | 2 |
| Dobutamin | 2 |
| Hypertonic lactate | 2 |
| Delayed Cord Clamping (DCC) | 1 |
Showing 5 of 11 interventions.
These are the names sponsors entered on ClinicalTrials.gov that we have not matched to a single molecule. Some are drugs under a brand or code name; others are procedures, doses or arm labels.
Which serious adverse events do Cardiac Output, Low trials report? (10)
Shown in this order: most subjects affected first. Subjects affected summed across trials, a cross-trial signal, not a rate.
| Adverse event | Subjects affected | Trials |
|---|---|---|
| Multiple heart failure symptoms | 91 | 1 |
| Dyspnea - Heart failure | 31 | 1 |
| Heart failure symptoms - Unspecified | 27 | 1 |
| Chest pain - Heart failure | 25 | 1 |
| Gastrointestinal | 25 | 1 |
Showing 5 of 10 adverse events.
Which publications cover Cardiac Output, Low? (260)
Shown in this order: major-topic papers first, then newest, then most linked to trials.
| Publication | Journal | Year | Major topic |
|---|---|---|---|
| Prophylactic use of inotropic agents for the prevention of low cardiac output syndrome and mortality in adults undergoing cardiac surgery. | The Cochrane database of systematic reviews | 2024 | Yes |
| Circulatory trajectories after out-of-hospital cardiac arrest: a prospective cohort study. | BMC anesthesiology | 2021 | Yes |
| Effects of milrinone on renal perfusion, filtration and oxygenation in patients with acute heart failure and low cardiac output early after cardiac surgery. | Journal of critical care | 2020 | Yes |
| ECG AI-Guided Screening for Low Ejection Fraction (EAGLE): Rationale and design of a pragmatic cluster randomized trial. | American heart journal | 2020 | Yes |
| Long-term outcome of perioperative low cardiac output syndrome in cardiac surgery: 1-year results of a multicenter randomized trial. | Journal of critical care | 2020 | Yes |
Showing 5 of 260 publications.
Not on this page
Not measured: delivery record.
Checked, with nothing recorded for this condition: prevalence, rare-disease identity, and sub-conditions in mesh.