Condition (MeSH)
Cataract
ClinicalTrials.gov lists 1,412 trials for Cataract or a narrower condition beneath it. Alcon Research has the most among industry and government lead sponsors, with 114.
Search trials, drugs, companies and investigators, and follow each one to the others. Individual plan, $249/seat/mo. Card required.
Trials per phase (log scale)
1 more section with rows
1,405 of the 1,412 trials are tagged with Cataract itself; the rest are tagged with a narrower condition beneath it.
When did Cataract trials start? (36)
Shown in this order: most recent first, 1990 onwards. 2026 is partial: trials registered with a 2026 start date so far, not a full year. 1 trial is registered to start in 2027 or later, and not listed here.
Trials over time, by phase
- Phase 1
- Phase 1/2
- Phase 2
- Phase 2/3
- Phase 3
- Phase 4
- Not applicable
- Observational
- Other (Unknown)
Top of scale: 101
Trials registered with a start date in each year, 1990 onward, stacked by phase (complete years only; the current partial year is in the table's notes). The table below lists the same counts, most recent years first.
| Year | Trials started |
|---|---|
| 2026 (partial year) | 65 |
| 2025 | 86 |
| 2024 | 80 |
| 2023 | 89 |
| 2022 | 101 |
| 2021 | 93 |
| 2020 | 80 |
| 2019 | 73 |
| 2018 | 85 |
| 2017 | 61 |
Showing 10 of 36 earlier years.
Forecast of the full-year count, planned starts included, not rows of this table: about 84 trials starting in 2026 and about 82 in 2027, the average of the 24 months through September, counted as registered and carried forward, with about 0.7 times the starts already registered for the rest of 2026 added. The rows of this table count trials registered so far with a start date in the year, planned starts included; the forecast looks ahead to the count for the whole year, so it is not the same measure. In backtests on conditions of this size, forecasts made part-way through the year were typically off by about 15 percent and ran about 1 percent high against the count later registered; forecasts made before the year began were off by about 26 percent and ran about 20 percent low against the count later registered. The part-way figures are from forecasts that used a multiple fitted only on earlier years. These figures rest on a few years of history (target years from 2018 to 2025, varying by figure), place each condition as it is mapped today rather than as it was then, and score against a count for the newest year that was still being revised. Only condition series were scored.
Prediction, not a registry value: median of 27 months from start to primary completion across 83 trials still running at the 2026-10-09 snapshot; registered median of 14 months across 928 trials with a primary completion typed Actual. Source: ClinicalTrials.gov / AACT (CTTI), public domain.
What phase are Cataract trials in? (9)
Shown in this order: phase order.
Show the trials by phase as a table
| Phase | Trials |
|---|---|
| Phase 1 | 16 |
| Phase 1/2 | 14 |
| Phase 2 | 25 |
| Phase 2/3 | 6 |
| Phase 3 | 89 |
| Phase 4 | 159 |
| Not applicable | 689 |
| Observational | 410 |
| Unknown | 4 |
How many Cataract trials are recruiting? (8)
Shown in this order: the order a trial moves through, from not yet recruiting to unknown.
| Status | Trials |
|---|---|
| Not yet recruiting | 50 |
| Recruiting | 105 |
| Enrolling by invitation | 11 |
| Active, not recruiting | 35 |
| Completed | 884 |
Showing 5 of 8 statuses.
Status as registered on ClinicalTrials.gov. Each trial is counted once.
Which lead sponsors run the most Cataract trials? (8)
Shown in this order: most trials first. Lead sponsors the registry classes as industry, NIH, US federal, other government or network. A hospital or university the registry files as government can appear here. Sponsors it classes as academic or other are shown on the full page, because that class cannot separate an institution from a named investigator.
| Sponsor | Trials |
|---|---|
| Alcon Research | 114 |
| Bausch & Lomb Incorporated | 37 |
| Beaver-Visitec International, Inc. | 36 |
| Johnson & Johnson Surgical Vision, Inc. | 26 |
| National Eye Institute (NEI) | 25 |
Showing 5 of 8 sponsors.
Which drugs are being tested for Cataract? (4)
Shown in this order: most trials first. One row per drug, matched to a single molecule under all its names, ranked by number of trials.
| Drug | Trials |
|---|---|
| PREDNISOLONE | 15 |
| Bromfenac | 12 |
| Nepafenac | 7 |
| Mapracorat | 5 |
Interventions as named in the registry (11)
Shown in this order: most trials first.
| Drug | Trials |
|---|---|
| Cataract surgery | 92 |
| Dexamethasone/Dexamethasone acetate | 17 |
| C: moxifloxacin | 7 |
| Triamcinolone Acetonide alone | 6 |
| Sodium Hyaluronate 1% | 5 |
Showing 5 of 11 interventions.
These are the names sponsors entered on ClinicalTrials.gov that we have not matched to a single molecule. Some are drugs under a brand or code name; others are procedures, doses or arm labels.
Which serious adverse events do Cataract trials report? (10)
Shown in this order: most subjects affected first. Subjects affected summed across trials, a cross-trial signal, not a rate.
| Adverse event | Subjects affected | Trials |
|---|---|---|
| hospitalization | 602 | 1 |
| Cardiac Disorders | 428 | 1 |
| Infections and infestations | 394 | 1 |
| Neoplasms benign, malignant and unspecified (incl cysts and polyps) | 343 | 1 |
| Musculoskeletal and connective tissue disorders | 296 | 1 |
Showing 5 of 10 adverse events.
Which publications cover Cataract? (780)
Shown in this order: major-topic papers first, then newest, then most linked to trials.
| Publication | Journal | Year | Major topic |
|---|---|---|---|
| Clinical outcomes of plate-haptic diffractive multifocal toric IOL in cataract eyes with long axial length and corneal astigmatism. | Scientific reports | 2025 | Yes |
| Two-Year Outcomes of Phacogoniotomy vs Phacotrabeculectomy for Advanced Primary Angle-Closure Glaucoma With Cataract: A Noninferiority Randomized Clinical Trial. | JAMA ophthalmology | 2025 | Yes |
| Anterior segment characteristics and spatial variations of different crystalline lens diseases. | Photodiagnosis and photodynamic therapy | 2025 | Yes |
| Ocular surface changes and corneal epithelial remodeling after cataract surgery in patients with type 2 diabetes: a case-control study. | BMC ophthalmology | 2025 | Yes |
| Phaco-trabeculectomy versus MSICS-trabeculectomy for coexisting cataract and glaucoma: visual and IOP outcomes from a randomized trial in Nigeria. | BMC ophthalmology | 2025 | Yes |
Showing 5 of 780 publications.
Sub-conditions in MeSH (1)
MeSH descendants one level down with at least one trial, most trials first.
Not on this page
Not measured: delivery record.
Checked, with nothing recorded for this condition: prevalence and rare-disease identity.