Condition (MeSH)
Cholangitis
ClinicalTrials.gov lists 214 trials for Cholangitis or a narrower condition beneath it. Gilead Sciences has the most among industry and government lead sponsors, with 7.
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Trials per phase (log scale)
74 of the 214 trials are tagged with Cholangitis itself; the rest are tagged with a narrower condition beneath it.
When did Cholangitis trials start? (27)
Shown in this order: most recent first, 1990 onwards. 2026 is partial: trials registered with a 2026 start date so far, not a full year.
Trials over time, by phase
- Phase 1
- Phase 1/2
- Phase 2
- Phase 2/3
- Phase 3
- Phase 4
- Not applicable
- Observational
Top of scale: 19
Trials registered with a start date in each year, 1990 onward, stacked by phase (complete years only; the current partial year is in the table's notes). The table below lists the same counts, most recent years first.
| Year | Trials started |
|---|---|
| 2026 (partial year) | 13 |
| 2025 | 9 |
| 2024 | 12 |
| 2023 | 14 |
| 2022 | 10 |
| 2021 | 19 |
| 2020 | 10 |
| 2019 | 12 |
| 2018 | 13 |
| 2017 | 13 |
Showing 10 of 27 earlier years.
Forecast of the full-year count, planned starts included, not rows of this table: about 14 trials starting in 2026 and about 11 in 2027, the average of the 24 months through September, counted as registered and carried forward. The rows of this table count trials registered so far with a start date in the year, planned starts included; the forecast looks ahead to the count for the whole year, so it is not the same measure. In backtests on conditions of this size, forecasts made part-way through the year were typically off by about 28 percent and ran about 20 percent low against the count later registered; forecasts made before the year began were off by about 39 percent and ran about 37 percent low against the count later registered. These figures rest on a few years of history (target years from 2018 to 2025, varying by figure), place each condition as it is mapped today rather than as it was then, and score against a count for the newest year that was still being revised. Only condition series were scored.
Prediction, not a registry value: median of 36 months from start to primary completion across 16 trials still running at the 2026-10-09 snapshot; registered median of 27 months across 120 trials with a primary completion typed Actual. Source: ClinicalTrials.gov / AACT (CTTI), public domain.
What phase are Cholangitis trials in? (8)
Shown in this order: phase order.
Show the trials by phase as a table
| Phase | Trials |
|---|---|
| Phase 1 | 23 |
| Phase 1/2 | 5 |
| Phase 2 | 47 |
| Phase 2/3 | 3 |
| Phase 3 | 14 |
| Phase 4 | 6 |
| Not applicable | 44 |
| Observational | 72 |
How many Cholangitis trials are recruiting? (7)
Shown in this order: the order a trial moves through, from not yet recruiting to unknown.
| Status | Trials |
|---|---|
| Not yet recruiting | 12 |
| Recruiting | 37 |
| Active, not recruiting | 9 |
| Completed | 94 |
| Terminated | 19 |
Showing 5 of 7 statuses.
Status as registered on ClinicalTrials.gov. Each trial is counted once.
Which lead sponsors run the most Cholangitis trials? (6)
Shown in this order: most trials first. Lead sponsors the registry classes as industry, NIH, US federal, other government or network. A hospital or university the registry files as government can appear here. Sponsors it classes as academic or other are shown on the full page, because that class cannot separate an institution from a named investigator.
| Sponsor | Trials |
|---|---|
| Gilead Sciences | 7 |
| HighTide Therapeutics (Hong Kong) Limited | 4 |
| Mirum Pharmaceuticals, Inc. | 4 |
| Dr. Falk Pharma GmbH | 3 |
| National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) | 3 |
Showing 5 of 6 sponsors.
Which drugs are being tested for Cholangitis? (7)
Shown in this order: most trials first. One row per drug, matched to a single molecule under all its names, ranked by number of trials.
| Drug | Trials |
|---|---|
| Ursodeoxycholic Acid | 5 |
| HTD1801 | 4 |
| Cilofexor | 4 |
| Elafibranor | 2 |
| PMI-150 (intranasal ketamine) | 2 |
Showing 5 of 7 drugs.
Interventions as named in the registry (8)
Shown in this order: most trials first.
| Drug | Trials |
|---|---|
| Vancomycin 1.1% | 12 |
| Fecal Microbiota Transplantation | 2 |
| Ceftriaxone 4g/ 24h | 2 |
| Fenofibrate IDD-P (Insoluble Drug Delivery-Micro Particle) | 2 |
| All-Trans Retinoid Acid(ATRA) | 2 |
Showing 5 of 8 interventions.
These are the names sponsors entered on ClinicalTrials.gov that we have not matched to a single molecule. Some are drugs under a brand or code name; others are procedures, doses or arm labels.
Which serious adverse events do Cholangitis trials report? (10)
Shown in this order: most subjects affected first. Subjects affected summed across trials, a cross-trial signal, not a rate.
| Adverse event | Subjects affected | Trials |
|---|---|---|
| Cholangitis | 47 | 8 |
| Abdominal pain | 12 | 4 |
| Cholangitis acute | 8 | 3 |
| Abdominal pain upper | 7 | 4 |
| Other | 7 | 1 |
Showing 5 of 10 adverse events.
Which publications cover Cholangitis? (138)
Shown in this order: major-topic papers first, then newest, then most linked to trials.
| Publication | Journal | Year | Major topic |
|---|---|---|---|
| Oral nonabsorbable antibiotics for prevention of recurrent cholangitis; a brief report study. | Infection | 2025 | Yes |
| Randomized Trial of Prophylactic Antibiotics for Endoscopic Retrograde Cholangiopancreatography in Patients With Biliary Obstruction. | The American journal of gastroenterology | 2024 | Yes |
| Recurrent cholangitis in patients with a non-stenotic hepaticojejunostomy: incidence and risk factors. | HPB : the official journal of the International Hepato Pancreato Biliary Association | 2024 | Yes |
| Severity assessment to guide empiric antibiotic therapy for cholangitis in children after Kasai portoenterostomy: a multicenter prospective randomized control trial in China. | International journal of surgery (London, England) | 2023 | Yes |
| APASL clinical practice guidance: the diagnosis and management of patients with primary biliary cholangitis. | Hepatology international | 2022 | Yes |
Showing 5 of 138 publications.
Sub-conditions in MeSH (1)
MeSH descendants one level down with at least one trial, most trials first.
Not on this page
Not measured: delivery record.
Checked, with nothing recorded for this condition: prevalence and rare-disease identity.