Condition (MeSH)
Cholelithiasis
ClinicalTrials.gov lists 483 trials for Cholelithiasis or a narrower condition beneath it.
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Trials per phase (log scale)
1 more section with rows
179 of the 483 trials are tagged with Cholelithiasis itself; the rest are tagged with a narrower condition beneath it.
When did Cholelithiasis trials start? (29)
Shown in this order: most recent first, 1990 onwards. 2026 is partial: trials registered with a 2026 start date so far, not a full year. 1 trial is registered to start in 2027 or later, and not listed here.
Trials over time, by phase
- Phase 1
- Phase 1/2
- Phase 2
- Phase 2/3
- Phase 3
- Phase 4
- Not applicable
- Observational
- Other (Unknown)
Top of scale: 41
Trials registered with a start date in each year, 1990 onward, stacked by phase (complete years only; the current partial year is in the table's notes). The table below lists the same counts, most recent years first.
| Year | Trials started |
|---|---|
| 2026 (partial year) | 29 |
| 2025 | 27 |
| 2024 | 41 |
| 2023 | 36 |
| 2022 | 24 |
| 2021 | 38 |
| 2020 | 23 |
| 2019 | 33 |
| 2018 | 14 |
| 2017 | 21 |
Showing 10 of 29 earlier years.
Forecast of the full-year count, planned starts included, not rows of this table: about 36 trials starting in 2026 and about 32 in 2027, the average of the 24 months through September, counted as registered and carried forward, with about 0.7 times the starts already registered for the rest of 2026 added. The rows of this table count trials registered so far with a start date in the year, planned starts included; the forecast looks ahead to the count for the whole year, so it is not the same measure. In backtests on conditions of this size, forecasts made part-way through the year were typically off by about 15 percent and ran about 1 percent high against the count later registered; forecasts made before the year began were off by about 26 percent and ran about 20 percent low against the count later registered. The part-way figures are from forecasts that used a multiple fitted only on earlier years. These figures rest on a few years of history (target years from 2018 to 2025, varying by figure), place each condition as it is mapped today rather than as it was then, and score against a count for the newest year that was still being revised. Only condition series were scored.
Prediction, not a registry value: median of 35 months from start to primary completion across 41 trials still running at the 2026-10-09 snapshot; registered median of 18 months across 284 trials with a primary completion typed Actual. Source: ClinicalTrials.gov / AACT (CTTI), public domain.
What phase are Cholelithiasis trials in? (9)
Shown in this order: phase order.
Show the trials by phase as a table
| Phase | Trials |
|---|---|
| Phase 1 | 8 |
| Phase 1/2 | 2 |
| Phase 2 | 10 |
| Phase 2/3 | 2 |
| Phase 3 | 9 |
| Phase 4 | 35 |
| Not applicable | 264 |
| Observational | 152 |
| Unknown | 1 |
How many Cholelithiasis trials are recruiting? (9)
Shown in this order: the order a trial moves through, from not yet recruiting to unknown.
| Status | Trials |
|---|---|
| Not yet recruiting | 23 |
| Recruiting | 51 |
| Enrolling by invitation | 1 |
| Active, not recruiting | 8 |
| Completed | 263 |
Showing 5 of 9 statuses.
Status as registered on ClinicalTrials.gov. Each trial is counted once.
Which drugs are being tested for Cholelithiasis? (5)
Shown in this order: most trials first. One row per drug, matched to a single molecule under all its names, ranked by number of trials.
| Drug | Trials |
|---|---|
| Ursodeoxycholic Acid | 8 |
| PMI-150 (intranasal ketamine) | 4 |
| Levobupivacaine | 3 |
| +/- Bupivacaine HCl | 3 |
| PROPOFOL | 2 |
Interventions as named in the registry (10)
Shown in this order: most trials first.
| Drug | Trials |
|---|---|
| Indocyanine Green dye | 6 |
| L:Lidocaine | 3 |
| Acupuncture | 2 |
| Remimazolam TIVA | 2 |
| D. Midazolam | 2 |
Showing 5 of 10 interventions.
These are the names sponsors entered on ClinicalTrials.gov that we have not matched to a single molecule. Some are drugs under a brand or code name; others are procedures, doses or arm labels.
Which serious adverse events do Cholelithiasis trials report? (10)
Shown in this order: most subjects affected first. Subjects affected summed across trials, a cross-trial signal, not a rate.
| Adverse event | Subjects affected | Trials |
|---|---|---|
| Post ERCP pancreatitis (PEP) | 11 | 1 |
| Pancreatitis | 8 | 1 |
| Post-sphincterotomy bleeding | 4 | 1 |
| Bile Duct Injury | 2 | 1 |
| Cholangitis | 2 | 1 |
Showing 5 of 10 adverse events.
Which publications cover Cholelithiasis? (259)
Shown in this order: major-topic papers first, then newest, then most linked to trials.
| Publication | Journal | Year | Major topic |
|---|---|---|---|
| Evaluation of Risk Factors Leading to Conversion from Laparoscopic Cholecystectomy to Open Surgery: A Retrospective Controlled Study. | Journal of laparoendoscopic & advanced surgical techniques. Part A | 2025 | Yes |
| Association of Glucagon-Like Peptide-1 Receptor Agonist Use With Risk of Gallbladder and Biliary Diseases: A Systematic Review and Meta-analysis of Randomized Clinical Trials. | JAMA internal medicine | 2022 | Yes |
| Symptomatic Cholelithiasis: Do Minority Patients Experience Delays to Surgery? | The Journal of surgical research | 2022 | Yes |
| Near infrared indocyanine green fluorescent cholangiography versus intraoperative cholangiography to improve safety in laparoscopic cholecystectomy for gallstone disease-a systematic review protocol. | Systematic reviews | 2022 | Yes |
| Safety of Semaglutide. | Frontiers in endocrinology | 2021 | Yes |
Showing 5 of 259 publications.
Sub-conditions in MeSH (3)
MeSH descendants one level down with at least one trial, most trials first.
Not on this page
Not measured: delivery record.
Checked, with nothing recorded for this condition: lead sponsors, prevalence, and rare-disease identity.