Condition (MeSH)
Eisenmenger Complex
ClinicalTrials.gov lists 23 trials for Eisenmenger Complex or a narrower condition beneath it. Actelion has the most among industry and government lead sponsors, with 3.
Search trials, drugs, companies and investigators, and follow each one to the others. Individual plan, $249/seat/mo. Card required.
Trials per phase
23 of the 23 trials are tagged with Eisenmenger Complex itself; the rest are tagged with a narrower condition beneath it.
When did Eisenmenger Complex trials start? (14)
Shown in this order: most recent first, 1990 onwards. 2026 is partial: trials registered with a 2026 start date so far, not a full year.
Trials over time, by phase
- Phase 1
- Phase 2
- Phase 3
- Phase 4
- Not applicable
- Observational
Top of scale: 5
Trials registered with a start date in each year, 1990 onward, stacked by phase (complete years only; the current partial year is in the table's notes). The table below lists the same counts, most recent years first.
| Year | Trials started |
|---|---|
| 2026 (partial year) | 1 |
| 2025 | 1 |
| 2022 | 1 |
| 2021 | 1 |
| 2018 | 1 |
| 2016 | 1 |
| 2013 | 4 |
| 2012 | 5 |
| 2011 | 1 |
| 2008 | 1 |
Showing 10 of 14 earlier years.
No forecast is made for this condition: it averages 0.6 trial starts a year over the five years to September, under the 5 a year the method needs.
Recruitment duration, a model prediction: none of the 23 trials evaluated at the 2026-10-09 snapshot is predicted and still running. Source: ClinicalTrials.gov / AACT (CTTI), public domain.
What phase are Eisenmenger Complex trials in? (6)
Shown in this order: phase order.
Show the trials by phase as a table
| Phase | Trials |
|---|---|
| Phase 1 | 1 |
| Phase 2 | 2 |
| Phase 3 | 4 |
| Phase 4 | 2 |
| Not applicable | 6 |
| Observational | 8 |
How many Eisenmenger Complex trials are recruiting? (5)
Shown in this order: the order a trial moves through, from not yet recruiting to unknown.
| Status | Trials |
|---|---|
| Not yet recruiting | 1 |
| Recruiting | 3 |
| Completed | 11 |
| Terminated | 3 |
| Unknown status | 5 |
Status as registered on ClinicalTrials.gov. Each trial is counted once.
Which lead sponsors run the most Eisenmenger Complex trials? (3)
Shown in this order: most trials first. Lead sponsors the registry classes as industry, NIH, US federal, other government or network. A hospital or university the registry files as government can appear here. Sponsors it classes as academic or other are shown on the full page, because that class cannot separate an institution from a named investigator.
| Sponsor | Trials |
|---|---|
| Actelion | 3 |
| Competence Network for Congenital Heart Defects | 2 |
| Govind Ballabh Pant Hospital | 1 |
Which drugs are being tested for Eisenmenger Complex? (4)
Shown in this order: most trials first. One row per drug, matched to a single molecule under all its names, ranked by number of trials.
| Drug | Trials |
|---|---|
| SILDENAFIL | 1 |
| ILOPROST | 1 |
| L-Citrulline Malate | 1 |
| Pentoxifylline | 1 |
Interventions as named in the registry (6)
Shown in this order: most trials first.
| Drug | Trials |
|---|---|
| Sotatercept Autoinjector | 2 |
| Macitentan Dose 3 | 2 |
| Bosentan administration | 1 |
| Oxygen supplementation | 1 |
| vasodilator-based PAH therapy | 1 |
Showing 5 of 6 interventions.
These are the names sponsors entered on ClinicalTrials.gov that we have not matched to a single molecule. Some are drugs under a brand or code name; others are procedures, doses or arm labels.
Which serious adverse events do Eisenmenger Complex trials report? (10)
Shown in this order: most subjects affected first. Subjects affected summed across trials, a cross-trial signal, not a rate.
| Adverse event | Subjects affected | Trials |
|---|---|---|
| Haemoptysis | 9 | 1 |
| Right ventricular failure | 9 | 2 |
| infective endocarditis | 9 | 1 |
| Pneumonia | 7 | 2 |
| Pulmonary arterial hypertension | 4 | 1 |
Showing 5 of 10 adverse events.
Which publications cover Eisenmenger Complex? (23)
Shown in this order: major-topic papers first, then newest, then most linked to trials.
| Publication | Journal | Year | Major topic |
|---|---|---|---|
| Evaluation of Macitentan in Patients With Eisenmenger Syndrome. | Circulation | 2019 | Yes |
| Long-Term Outcome of Patients with Perimembranous Ventricular Septal Defect: Results from the Belgian Registry on Adult Congenital Heart Disease. | Cardiology | 2017 | Yes |
| Survival and outcomes of patients with unoperated single ventricle. | Heart (British Cardiac Society) | 2016 | Yes |
| Health-related quality of life of patients with pulmonary arterial hypertension associated with CHD: the multicentre cross-sectional ACHILLE study. | Cardiology in the young | 2016 | Yes |
| Replacement therapy for iron deficiency improves exercise capacity and quality of life in patients with cyanotic congenital heart disease and/or the Eisenmenger syndrome. | International journal of cardiology | 2011 | Yes |
Showing 5 of 23 publications.
Prevalence (2)
Shown in this order: jurisdiction, then disease name. Orphanet observation for the mapped ORPHA concept; the mapping relation column says whether that concept is exactly this condition or broader or narrower.
| Orphanet disease | Type | Class | Geography | Jurisdiction | Mapping relation |
|---|---|---|---|---|---|
| Eisenmenger syndrome | Point prevalence | 1-9 / 1 000 000 | Belgium | Not stated | Unspecified |
| Eisenmenger syndrome | Point prevalence | 1-9 / 1 000 000 | Europe | Not stated | Unspecified |
Not on this page
Not measured: delivery record.
Checked, with nothing recorded for this condition: rare-disease identity and sub-conditions in mesh.