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Condition (MeSH)

Esophageal Achalasia

ClinicalTrials.gov lists 138 trials for Esophageal Achalasia or a narrower condition beneath it.

MeSH D004931 Digestive System Diseases C06
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Phase 1 Phase 1 1 Phase 1/2 Phase 1/2 2 Phase 2 Phase 2 5 Phase 2/3 Phase 2/3 2 Phase 3 Phase 3 5 Phase 4 Phase 4 7 Not applicable Not applicable 72 Observational Observational 44 Phase 1 Phase 1 1 Phase 1/2 Phase 1/2 2 Phase 2 Phase 2 5 Phase 2/3 Phase 2/3 2 Phase 3 Phase 3 5 Phase 4 Phase 4 7 Not applicable Not applicable 72 Observational Observational 44

Trials per phase (log scale)

138 of the 138 trials are tagged with Esophageal Achalasia itself; the rest are tagged with a narrower condition beneath it.

Get the Esophageal Achalasia report as a PDF

The PDF carries up to 50 rows of each section, where the page shows the first few, with the sources listed. Enter a work email and confirm it from the message we send, and the report follows by email.

When did Esophageal Achalasia trials start? (27)

Shown in this order: most recent first, 1990 onwards. 2026 is partial: trials registered with a 2026 start date so far, not a full year.

Trials over time, by phase

  • Phase 1
  • Phase 1/2
  • Phase 2
  • Phase 2/3
  • Phase 3
  • Phase 4
  • Not applicable
  • Observational

Top of scale: 11

1997: 1 trials (Not applicable 1) 1999: 1 trials (Observational 1) 2000: 1 trials (Phase 2 1) 2003: 1 trials (Not applicable 1) 2004: 1 trials (Phase 4 1) 2005: 1 trials (Not applicable 1) 2006: 1 trials (Observational 1) 2007: 4 trials (Observational 1, Not applicable 3) 2008: 2 trials (Observational 1, Phase 1/2 1) 2009: 1 trials (Observational 1) 2010: 11 trials (Observational 2, Not applicable 7, Phase 2 2) 2011: 4 trials (Not applicable 4) 2012: 10 trials (Not applicable 6, Phase 4 1, Phase 3 1, Phase 2 1, Phase 1/2 1) 2013: 6 trials (Observational 2, Not applicable 3, Phase 4 1) 2014: 9 trials (Observational 3, Not applicable 6) 2015: 4 trials (Observational 1, Not applicable 3) 2016: 5 trials (Not applicable 5) 2017: 9 trials (Observational 4, Not applicable 3, Phase 2/3 1, Phase 2 1) 2018: 5 trials (Observational 1, Not applicable 2, Phase 3 1, Phase 1 1) 2019: 10 trials (Observational 3, Not applicable 6, Phase 4 1) 2020: 3 trials (Not applicable 2, Phase 4 1) 2021: 10 trials (Observational 8, Not applicable 1, Phase 4 1) 2022: 4 trials (Observational 2, Not applicable 2) 2023: 9 trials (Observational 5, Not applicable 3, Phase 4 1) 2024: 8 trials (Observational 1, Not applicable 5, Phase 3 1, Phase 2/3 1) 2025: 4 trials (Observational 1, Not applicable 3)

Trials registered with a start date in each year, 1990 onward, stacked by phase (complete years only; the current partial year is in the table's notes). The table below lists the same counts, most recent years first.

Trials started per year
Year Trials started
2026 (partial year) 12
2025 4
2024 8
2023 9
2022 4
2021 10
2020 3
2019 10
2018 5
2017 9

Forecast of the full-year count, planned starts included, not rows of this table: about 12 trials starting in 2026 and about 8 in 2027, the average of the 24 months through September, counted as registered and carried forward. The rows of this table count trials registered so far with a start date in the year, planned starts included; the forecast looks ahead to the count for the whole year, so it is not the same measure. In backtests on conditions of this size, forecasts made part-way through the year were typically off by about 28 percent and ran about 20 percent low against the count later registered; forecasts made before the year began were off by about 39 percent and ran about 37 percent low against the count later registered. These figures rest on a few years of history (target years from 2018 to 2025, varying by figure), place each condition as it is mapped today rather than as it was then, and score against a count for the newest year that was still being revised. Only condition series were scored.

Prediction, not a registry value: median of 36 months from start to primary completion across 13 trials still running at the 2026-10-09 snapshot; registered median of 32 months across 63 trials with a primary completion typed Actual. Source: ClinicalTrials.gov / AACT (CTTI), public domain.

What phase are Esophageal Achalasia trials in? (8)

Shown in this order: phase order.

Show the trials by phase as a table
Trials by phase
Phase Trials
Phase 1 1
Phase 1/2 2
Phase 2 5
Phase 2/3 2
Phase 3 5
Phase 4 7
Not applicable 72
Observational 44

How many Esophageal Achalasia trials are recruiting? (8)

Shown in this order: the order a trial moves through, from not yet recruiting to unknown.

Trials by recruitment status
Status Trials
Not yet recruiting 7
Recruiting 23
Enrolling by invitation 4
Active, not recruiting 5
Completed 48

Status as registered on ClinicalTrials.gov. Each trial is counted once.

Interventions as named in the registry (15)

Shown in this order: most trials first.

Interventions as named in the registry
Drug Trials
type A botulinum toxin 3
domperidone or esomeprazole (Conservative management) 1
Valacyclovir arrow 1
Ropivacaine 2 % 1
Nexium Pill 1

These are the names sponsors entered on ClinicalTrials.gov that we have not matched to a single molecule. Some are drugs under a brand or code name; others are procedures, doses or arm labels.

Which serious adverse events do Esophageal Achalasia trials report? (2)

Shown in this order: most subjects affected first. Subjects affected summed across trials, a cross-trial signal, not a rate.

Serious adverse events in this condition's trials
Adverse event Subjects affected Trials
1 cm superficial ulcer (Forrest III) 1 1
ulcer in the distal esophagus 1 1

Which publications cover Esophageal Achalasia? (231)

Shown in this order: major-topic papers first, then newest, then most linked to trials.

Not on this page

Not measured: delivery record.

Checked, with nothing recorded for this condition: lead sponsors, prevalence, rare-disease identity, and sub-conditions in mesh.

Browse all condition evidence pages