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Condition (MeSH)

Heart Arrest

ClinicalTrials.gov lists 1,376 trials for Heart Arrest or a narrower condition beneath it. National Heart, Lung, and Blood Institute (NHLBI) has the most among industry and government lead sponsors, with 15.

MeSH D006323 Cardiovascular Diseases C14
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Phase 1 Phase 1 27 Phase 1/2 Phase 1/2 8 Phase 2 Phase 2 56 Phase 2/3 Phase 2/3 11 Phase 3 Phase 3 56 Phase 4 Phase 4 47 Not applicable Not applicable 539 Observational Observational 632 Phase 1 Phase 1 27 Phase 1/2 Phase 1/2 8 Phase 2 Phase 2 56 Phase 2/3 Phase 2/3 11 Phase 3 Phase 3 56 Phase 4 Phase 4 47 Not applicable Not applicable 539 Observational Observational 632

Trials per phase (log scale)

895 of the 1,376 trials are tagged with Heart Arrest itself; the rest are tagged with a narrower condition beneath it.

Get the Heart Arrest report as a PDF

The PDF carries up to 50 rows of each section, where the page shows the first few, with the sources listed. Enter a work email and confirm it from the message we send, and the report follows by email.

When did Heart Arrest trials start? (36)

Shown in this order: most recent first, 1990 onwards. 2026 is partial: trials registered with a 2026 start date so far, not a full year. 5 trials are registered to start in 2027 or later, and not listed here.

Trials over time, by phase

  • Phase 1
  • Phase 1/2
  • Phase 2
  • Phase 2/3
  • Phase 3
  • Phase 4
  • Not applicable
  • Observational

Top of scale: 107

1990: 3 trials (Observational 3) 1991: 1 trials (Phase 3 1) 1992: 4 trials (Observational 1, Not applicable 1, Phase 3 2) 1993: 2 trials (Observational 2) 1994: 2 trials (Observational 2) 1996: 3 trials (Observational 2, Phase 4 1) 1997: 4 trials (Observational 2, Not applicable 1, Phase 3 1) 1998: 2 trials (Observational 2) 1999: 3 trials (Observational 1, Phase 3 1, Phase 1 1) 2000: 1 trials (Observational 1) 2001: 4 trials (Observational 2, Phase 3 1, Phase 2 1) 2002: 7 trials (Observational 2, Not applicable 1, Phase 4 1, Phase 3 1, Phase 2/3 1, Phase 2 1) 2003: 14 trials (Observational 8, Not applicable 3, Phase 4 1, Phase 3 1, Phase 2 1) 2004: 14 trials (Observational 4, Not applicable 1, Phase 4 2, Phase 3 3, Phase 2/3 1, Phase 2 2, Phase 1/2 1) 2005: 13 trials (Observational 7, Not applicable 3, Phase 3 2, Phase 2 1) 2006: 24 trials (Observational 10, Not applicable 4, Phase 4 2, Phase 3 2, Phase 2 3, Phase 1 3) 2007: 37 trials (Observational 20, Not applicable 8, Phase 4 1, Phase 3 2, Phase 2/3 1, Phase 2 2, Phase 1/2 2, Phase 1 1) 2008: 33 trials (Observational 12, Not applicable 7, Phase 4 7, Phase 3 4, Phase 2/3 1, Phase 2 1, Phase 1 1) 2009: 25 trials (Observational 10, Not applicable 7, Phase 4 1, Phase 3 3, Phase 2 2, Phase 1 2) 2010: 42 trials (Observational 23, Not applicable 9, Phase 4 1, Phase 3 3, Phase 2 2, Phase 1/2 1, Phase 1 3) 2011: 34 trials (Observational 17, Not applicable 12, Phase 4 3, Phase 3 1, Phase 2 1) 2012: 35 trials (Observational 21, Not applicable 10, Phase 4 1, Phase 3 2, Phase 1/2 1) 2013: 59 trials (Observational 25, Not applicable 29, Phase 4 2, Phase 2 1, Phase 1 2) 2014: 94 trials (Observational 31, Not applicable 58, Phase 4 2, Phase 3 1, Phase 2 2) 2015: 49 trials (Observational 27, Not applicable 17, Phase 4 1, Phase 3 1, Phase 2 2, Phase 1 1) 2016: 85 trials (Observational 36, Not applicable 36, Phase 4 3, Phase 3 2, Phase 2 4, Phase 1/2 1, Phase 1 3) 2017: 71 trials (Observational 36, Not applicable 28, Phase 4 1, Phase 3 1, Phase 2 5) 2018: 71 trials (Observational 39, Not applicable 26, Phase 4 2, Phase 2/3 2, Phase 2 2) 2019: 70 trials (Observational 32, Not applicable 30, Phase 4 2, Phase 3 1, Phase 2 3, Phase 1 2) 2020: 61 trials (Observational 26, Not applicable 30, Phase 3 1, Phase 2 3, Phase 1 1) 2021: 86 trials (Observational 41, Not applicable 33, Phase 4 1, Phase 3 4, Phase 2 4, Phase 1/2 1, Phase 1 2) 2022: 62 trials (Observational 31, Not applicable 25, Phase 4 3, Phase 2/3 1, Phase 2 2) 2023: 84 trials (Observational 43, Not applicable 31, Phase 4 4, Phase 3 2, Phase 2 3, Phase 1 1) 2024: 87 trials (Observational 37, Not applicable 42, Phase 4 1, Phase 3 1, Phase 2/3 1, Phase 2 3, Phase 1/2 1, Phase 1 1) 2025: 107 trials (Observational 50, Not applicable 45, Phase 4 3, Phase 3 3, Phase 2/3 2, Phase 2 3, Phase 1 1)

Trials registered with a start date in each year, 1990 onward, stacked by phase (complete years only; the current partial year is in the table's notes). The table below lists the same counts, most recent years first.

Trials started per year
Year Trials started
2026 (partial year) 66
2025 107
2024 87
2023 84
2022 62
2021 86
2020 61
2019 70
2018 71
2017 71

Forecast of the full-year count, planned starts included, not rows of this table: about 89 trials starting in 2026 and about 96 in 2027, the average of the 24 months through September, counted as registered and carried forward, with about 0.7 times the starts already registered for the rest of 2026 added. The rows of this table count trials registered so far with a start date in the year, planned starts included; the forecast looks ahead to the count for the whole year, so it is not the same measure. In backtests on conditions of this size, forecasts made part-way through the year were typically off by about 15 percent and ran about 1 percent high against the count later registered; forecasts made before the year began were off by about 26 percent and ran about 20 percent low against the count later registered. The part-way figures are from forecasts that used a multiple fitted only on earlier years. These figures rest on a few years of history (target years from 2018 to 2025, varying by figure), place each condition as it is mapped today rather than as it was then, and score against a count for the newest year that was still being revised. Only condition series were scored.

Prediction, not a registry value: median of 36 months from start to primary completion across 117 trials still running at the 2026-10-09 snapshot; registered median of 27 months across 735 trials with a primary completion typed Actual. Source: ClinicalTrials.gov / AACT (CTTI), public domain.

What phase are Heart Arrest trials in? (8)

Shown in this order: phase order.

Show the trials by phase as a table
Trials by phase
Phase Trials
Phase 1 27
Phase 1/2 8
Phase 2 56
Phase 2/3 11
Phase 3 56
Phase 4 47
Not applicable 539
Observational 632

How many Heart Arrest trials are recruiting? (9)

Shown in this order: the order a trial moves through, from not yet recruiting to unknown.

Trials by recruitment status
Status Trials
Not yet recruiting 63
Recruiting 204
Enrolling by invitation 18
Active, not recruiting 52
Completed 681

Status as registered on ClinicalTrials.gov. Each trial is counted once.

Which lead sponsors run the most Heart Arrest trials? (3)

Shown in this order: most trials first. Lead sponsors the registry classes as industry, NIH, US federal, other government or network. A hospital or university the registry files as government can appear here. Sponsors it classes as academic or other are shown on the full page, because that class cannot separate an institution from a named investigator.

Lead sponsors
Sponsor Trials
National Heart, Lung, and Blood Institute (NHLBI) 15
Emergency Medical Services, Capital Region, Denmark 12
Zoll Medical Corporation 12

Which drugs are being tested for Heart Arrest? (3)

Shown in this order: most trials first. One row per drug, matched to a single molecule under all its names, ranked by number of trials.

Drugs tested
Drug Trials
PMI-150 (intranasal ketamine) 4
Esmeron 4
Domperidone 3

Interventions as named in the registry (12)

Shown in this order: most trials first.

Interventions as named in the registry
Drug Trials
amiodarone amiodarone 10
Epinephrin 8
sodium bicarbonate 8.4% 4
Optimal Medical Therapy 4
Blood Sampling 4

These are the names sponsors entered on ClinicalTrials.gov that we have not matched to a single molecule. Some are drugs under a brand or code name; others are procedures, doses or arm labels.

Which serious adverse events do Heart Arrest trials report? (10)

Shown in this order: most subjects affected first. Subjects affected summed across trials, a cross-trial signal, not a rate.

Serious adverse events in this condition's trials
Adverse event Subjects affected Trials
death 13,801 5
Pulmonary edema 882 2
CHD hospitalization, 1st event post-randomization 728 1
Pressors in first 24 hours after hospitalization 548 1
Airway bleeding 440 1

Which publications cover Heart Arrest? (1,437)

Shown in this order: major-topic papers first, then newest, then most linked to trials.

Sub-conditions in MeSH (2)

MeSH descendants one level down with at least one trial, most trials first.

Not on this page

Not measured: delivery record.

Checked, with nothing recorded for this condition: prevalence and rare-disease identity.

Browse all condition evidence pages