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Condition (MeSH)

Huntington Disease

ClinicalTrials.gov lists 291 trials for Huntington Disease or a narrower condition beneath it. Pfizer has the most among industry and government lead sponsors, with 12.

MeSH D006816 Nervous System Diseases C10 C16 F03 Listed by Orphanet as a rare disease
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Phase 1 Phase 1 45 Phase 1/2 Phase 1/2 18 Phase 2 Phase 2 51 Phase 2/3 Phase 2/3 7 Phase 3 Phase 3 22 Phase 4 Phase 4 4 Not applicable Not applicable 62 Observational Observational 82 Phase 1 Phase 1 45 Phase 1/2 Phase 1/2 18 Phase 2 Phase 2 51 Phase 2/3 Phase 2/3 7 Phase 3 Phase 3 22 Phase 4 Phase 4 4 Not applicable Not applicable 62 Observational Observational 82

Trials per phase (log scale)

291 of the 291 trials are tagged with Huntington Disease itself; the rest are tagged with a narrower condition beneath it.

Get the Huntington Disease report as a PDF

The PDF carries up to 50 rows of each section, where the page shows the first few, with the sources listed. Enter a work email and confirm it from the message we send, and the report follows by email.

When did Huntington Disease trials start? (28)

Shown in this order: most recent first, 1990 onwards. 2026 is partial: trials registered with a 2026 start date so far, not a full year.

Trials over time, by phase

  • Phase 1
  • Phase 1/2
  • Phase 2
  • Phase 2/3
  • Phase 3
  • Phase 4
  • Not applicable
  • Observational

Top of scale: 24

1993: 1 trials (Observational 1) 1999: 3 trials (Observational 1, Phase 3 1, Phase 2 1) 2001: 3 trials (Observational 1, Phase 1/2 2) 2002: 2 trials (Observational 1, Phase 2 1) 2003: 1 trials (Observational 1) 2004: 4 trials (Observational 1, Phase 4 1, Phase 2 1, Phase 1 1) 2005: 6 trials (Observational 1, Phase 3 1, Phase 2 4) 2006: 4 trials (Observational 2, Phase 2/3 1, Phase 1/2 1) 2007: 7 trials (Observational 4, Phase 2 2, Phase 1 1) 2008: 6 trials (Not applicable 1, Phase 3 2, Phase 2 1, Phase 1 2) 2009: 22 trials (Observational 2, Not applicable 2, Phase 3 3, Phase 2 2, Phase 1 13) 2010: 5 trials (Observational 1, Phase 3 1, Phase 2/3 1, Phase 2 2) 2011: 15 trials (Observational 4, Not applicable 2, Phase 2 5, Phase 1 4) 2012: 8 trials (Observational 3, Not applicable 3, Phase 2 2) 2013: 11 trials (Observational 3, Not applicable 2, Phase 4 1, Phase 3 2, Phase 2 2, Phase 1 1) 2014: 12 trials (Observational 1, Not applicable 4, Phase 2 5, Phase 1/2 1, Phase 1 1) 2015: 14 trials (Not applicable 8, Phase 2 4, Phase 1/2 1, Phase 1 1) 2016: 9 trials (Observational 3, Not applicable 4, Phase 2 1, Phase 1 1) 2017: 15 trials (Observational 5, Not applicable 4, Phase 2 1, Phase 1/2 3, Phase 1 2) 2018: 10 trials (Observational 1, Not applicable 2, Phase 4 1, Phase 2 3, Phase 1 3) 2019: 13 trials (Observational 5, Not applicable 1, Phase 3 3, Phase 2 1, Phase 1/2 2, Phase 1 1) 2020: 18 trials (Observational 7, Not applicable 4, Phase 3 2, Phase 2/3 1, Phase 2 2, Phase 1/2 1, Phase 1 1) 2021: 20 trials (Observational 8, Not applicable 6, Phase 2/3 1, Phase 2 1, Phase 1/2 2, Phase 1 2) 2022: 17 trials (Observational 6, Not applicable 2, Phase 3 2, Phase 2 4, Phase 1/2 1, Phase 1 2) 2023: 13 trials (Observational 4, Not applicable 3, Phase 2 3, Phase 1/2 1, Phase 1 2) 2024: 24 trials (Observational 8, Not applicable 8, Phase 4 1, Phase 3 2, Phase 2 2, Phase 1 3) 2025: 16 trials (Observational 7, Not applicable 4, Phase 2/3 1, Phase 2 1, Phase 1/2 2, Phase 1 1)

Trials registered with a start date in each year, 1990 onward, stacked by phase (complete years only; the current partial year is in the table's notes). The table below lists the same counts, most recent years first.

Trials started per year
Year Trials started
2026 (partial year) 11
2025 16
2024 24
2023 13
2022 17
2021 20
2020 18
2019 13
2018 10
2017 15

Showing 10 of 28 earlier years.

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Forecast of the full-year count, planned starts included, not rows of this table: about 15 trials starting in 2026 and about 16 in 2027, the average of the 24 months through September, counted as registered and carried forward. The rows of this table count trials registered so far with a start date in the year, planned starts included; the forecast looks ahead to the count for the whole year, so it is not the same measure. In backtests on conditions of this size, forecasts made part-way through the year were typically off by about 28 percent and ran about 20 percent low against the count later registered; forecasts made before the year began were off by about 39 percent and ran about 37 percent low against the count later registered. These figures rest on a few years of history (target years from 2018 to 2025, varying by figure), place each condition as it is mapped today rather than as it was then, and score against a count for the newest year that was still being revised. Only condition series were scored.

Prediction, not a registry value: median of 36 months from start to primary completion across 30 trials still running at the 2026-10-09 snapshot; registered median of 25 months across 181 trials with a primary completion typed Actual. Source: ClinicalTrials.gov / AACT (CTTI), public domain.

What phase are Huntington Disease trials in? (8)

Shown in this order: phase order.

Show the trials by phase as a table
Trials by phase
Phase Trials
Phase 1 45
Phase 1/2 18
Phase 2 51
Phase 2/3 7
Phase 3 22
Phase 4 4
Not applicable 62
Observational 82

How many Huntington Disease trials are recruiting? (8)

Shown in this order: the order a trial moves through, from not yet recruiting to unknown.

Trials by recruitment status
Status Trials
Not yet recruiting 6
Recruiting 39
Enrolling by invitation 2
Active, not recruiting 18
Completed 161

Showing 5 of 8 statuses.

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Status as registered on ClinicalTrials.gov. Each trial is counted once.

Which lead sponsors run the most Huntington Disease trials? (9)

Shown in this order: most trials first. Lead sponsors the registry classes as industry, NIH, US federal, other government or network. A hospital or university the registry files as government can appear here. Sponsors it classes as academic or other are shown on the full page, because that class cannot separate an institution from a named investigator.

Lead sponsors
Sponsor Trials
Pfizer 12
Hoffmann-La Roche 7
Institut National de la Santé Et de la Recherche Médicale, France 7
University Hospital, Angers 7
Prilenia 6

Showing 5 of 9 sponsors.

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Which drugs are being tested for Huntington Disease? (6)

Shown in this order: most trials first. One row per drug, matched to a single molecule under all its names, ranked by number of trials.

Drugs tested
Drug Trials
Pridopidine 8
Creatine 6
SAGE-718 4
SD-809 4
Valbenazine 3

Showing 5 of 6 drugs.

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Interventions as named in the registry (9)

Shown in this order: most trials first.

Interventions as named in the registry
Drug Trials
Dimebon 9
SEN0014196 4
LPM3770164 sustained release tablet 3
SKY-0515 3
BLOOD SAMPLE 3

Showing 5 of 9 interventions.

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These are the names sponsors entered on ClinicalTrials.gov that we have not matched to a single molecule. Some are drugs under a brand or code name; others are procedures, doses or arm labels.

Which serious adverse events do Huntington Disease trials report? (10)

Shown in this order: most subjects affected first. Subjects affected summed across trials, a cross-trial signal, not a rate.

Serious adverse events in this condition's trials
Adverse event Subjects affected Trials
Fall 30 13
SUICIDE ATTEMPT 21 2
Pneumonia 18 12
Suicidal ideation 17 9
Suicide attempt 17 10

Showing 5 of 10 adverse events.

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Which publications cover Huntington Disease? (340)

Shown in this order: major-topic papers first, then newest, then most linked to trials.

Publications
Publication Journal Year Major topic
Handgrip strength and the Index of pulmonary dysfunction: Practical screening tools for cough dysfunction in huntington's disease. Journal of Huntington's disease 2026 Yes
Oral splicing modulator branaplam in Huntington's disease: a phase 2 randomized controlled trial. Nature medicine 2026 Yes
Safety and Efficacy of Deutetrabenazine at High versus Lower Daily Dosages in the ARC-HD Study to Treat Chorea in Huntington Disease. CNS drugs 2025 Yes
Effect of Triheptanoin on Caudate Atrophy and Motor Scores in Patients With Early-Stage Huntington Disease: A Phase II Study. Neurology 2025 Yes
Somatic CAG repeat expansion in blood associates with biomarkers of neurodegeneration in Huntington's disease decades before clinical motor diagnosis. Nature medicine 2025 Yes

Showing 5 of 340 publications.

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Prevalence (96)

Shown in this order: jurisdiction, then disease name. Orphanet observation for the mapped ORPHA concept; the mapping relation column says whether that concept is exactly this condition or broader or narrower.

Prevalence
Orphanet disease Type Class Geography Jurisdiction Mapping relation
Huntington disease Annual incidence 1-9 / 1 000 000 United Kingdom GB Exact
Huntington disease Point prevalence 1-9 / 100 000 United Kingdom GB Exact
Huntington disease Annual incidence 1-9 / 1 000 000 United Kingdom GB Unspecified
Huntington disease Point prevalence 1-9 / 100 000 United Kingdom GB Exact
Huntington disease Annual incidence 1-9 / 1 000 000 United Kingdom GB Exact

Showing 5 of 96 prevalence observations.

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Rare-disease identity (2)

Shown in this order: exact, broader, narrower, other.

Rare-disease identity
Orphanet disease ORPHA code Relation Source
Huntington disease 399 Exact Orphanet Rare Disease Ontology (ORDO)
Huntington disease 399 Exact Orphadata Science knowledge files, Product 1

Not on this page

Not measured: delivery record.

Checked, with nothing recorded for this condition: sub-conditions in mesh.

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