Condition (MeSH)
Hyperalgesia
ClinicalTrials.gov lists 159 trials for Hyperalgesia or a narrower condition beneath it. National Institute of Dental and Craniofacial Research (NIDCR) has the most among industry and government lead sponsors, with 4.
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Trials per phase (log scale)
159 of the 159 trials are tagged with Hyperalgesia itself; the rest are tagged with a narrower condition beneath it.
When did Hyperalgesia trials start? (28)
Shown in this order: most recent first, 1990 onwards. 2026 is partial: trials registered with a 2026 start date so far, not a full year.
Trials over time, by phase
- Phase 1
- Phase 1/2
- Phase 2
- Phase 2/3
- Phase 3
- Phase 4
- Not applicable
- Observational
Top of scale: 14
Trials registered with a start date in each year, 1990 onward, stacked by phase (complete years only; the current partial year is in the table's notes). The table below lists the same counts, most recent years first.
| Year | Trials started |
|---|---|
| 2026 (partial year) | 4 |
| 2025 | 3 |
| 2024 | 3 |
| 2023 | 4 |
| 2022 | 6 |
| 2021 | 10 |
| 2020 | 6 |
| 2019 | 7 |
| 2018 | 9 |
| 2017 | 6 |
Showing 10 of 28 earlier years.
No forecast is made for this condition: it averages 4.0 trial starts a year over the five years to September, under the 5 a year the method needs.
Prediction, not a registry value: median of 36 months from start to primary completion across 6 trials still running at the 2026-10-09 snapshot; registered median of 12 months across 111 trials with a primary completion typed Actual. Source: ClinicalTrials.gov / AACT (CTTI), public domain.
What phase are Hyperalgesia trials in? (8)
Shown in this order: phase order.
Show the trials by phase as a table
| Phase | Trials |
|---|---|
| Phase 1 | 19 |
| Phase 1/2 | 2 |
| Phase 2 | 25 |
| Phase 2/3 | 1 |
| Phase 3 | 13 |
| Phase 4 | 31 |
| Not applicable | 50 |
| Observational | 18 |
How many Hyperalgesia trials are recruiting? (9)
Shown in this order: the order a trial moves through, from not yet recruiting to unknown.
| Status | Trials |
|---|---|
| Not yet recruiting | 3 |
| Recruiting | 6 |
| Enrolling by invitation | 1 |
| Active, not recruiting | 1 |
| Completed | 111 |
Showing 5 of 9 statuses.
Status as registered on ClinicalTrials.gov. Each trial is counted once.
Which lead sponsors run the most Hyperalgesia trials? (4)
Shown in this order: most trials first. Lead sponsors the registry classes as industry, NIH, US federal, other government or network. A hospital or university the registry files as government can appear here. Sponsors it classes as academic or other are shown on the full page, because that class cannot separate an institution from a named investigator.
| Sponsor | Trials |
|---|---|
| National Institute of Dental and Craniofacial Research (NIDCR) | 4 |
| GlaxoSmithKline | 3 |
| AstraZeneca | 2 |
| Axsome Therapeutics, Inc. | 2 |
Which drugs are being tested for Hyperalgesia? (4)
Shown in this order: most trials first. One row per drug, matched to a single molecule under all its names, ranked by number of trials.
| Drug | Trials |
|---|---|
| Remifentanil | 14 |
| PMI-150 (intranasal ketamine) | 8 |
| Pregabalin | 3 |
| Nerve Growth Factor | 3 |
Interventions as named in the registry (11)
Shown in this order: most trials first.
| Drug | Trials |
|---|---|
| L:Lidocaine | 7 |
| D. Midazolam | 4 |
| Capsaicin 8% | 3 |
| naloxone IM | 3 |
| Gabapentin 6% | 3 |
Showing 5 of 11 interventions.
These are the names sponsors entered on ClinicalTrials.gov that we have not matched to a single molecule. Some are drugs under a brand or code name; others are procedures, doses or arm labels.
Which serious adverse events do Hyperalgesia trials report? (10)
Shown in this order: most subjects affected first. Subjects affected summed across trials, a cross-trial signal, not a rate.
| Adverse event | Subjects affected | Trials |
|---|---|---|
| Allergy | 1 | 1 |
| Breast Cancer Stage II | 1 | 1 |
| Bronchopneumonia | 1 | 1 |
| Chest Pain | 1 | 1 |
| Coma | 1 | 1 |
Showing 5 of 10 adverse events.
Which publications cover Hyperalgesia? (772)
Shown in this order: major-topic papers first, then newest, then most linked to trials.
| Publication | Journal | Year | Major topic |
|---|---|---|---|
| Pressure pain sensitivity is independent of structural pathology in patients with subacromial pain syndrome: a cross-sectional analysis. | Pain medicine (Malden, Mass.) | 2025 | Yes |
| Postoperative pain evaluation in laparoscopic radical prostatectomy surgery using tranexamic acid: analgesia?, hyperalgesia?? | World journal of urology | 2025 | Yes |
| Inflammatory reactivity is unrelated to childhood adversity or provoked modulation of nociception. | Pain | 2025 | Yes |
| Effects of Non-Immersive Virtual Reality Exercise on Self-Reported Pain and Mechanical Hyperalgesia in Older Adults with Knee and Hip Osteoarthritis: A Secondary Analysis of a Randomized Controlled Trial. | Medicina (Kaunas, Lithuania) | 2025 | Yes |
| Provoked cytokine response is not associated with distress or induced secondary hyperalgesia in people with suppressed HIV. | Pain | 2025 | Yes |
Showing 5 of 772 publications.
Not on this page
Not measured: delivery record.
Checked, with nothing recorded for this condition: prevalence, rare-disease identity, and sub-conditions in mesh.