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Condition (MeSH)

Hypernatremia

ClinicalTrials.gov lists 46 trials for Hypernatremia or a narrower condition beneath it.

MeSH D006955 Nutritional and Metabolic Diseases C18
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Phase 1 Phase 1 1 Phase 1/2 Phase 1/2 1 Phase 2 Phase 2 3 Phase 3 Phase 3 2 Phase 4 Phase 4 5 Not applicable Not applicable 23 Observational Observational 11 Phase 1 Phase 1 1 Phase 1/2 Phase 1/2 1 Phase 2 Phase 2 3 Phase 3 Phase 3 2 Phase 4 Phase 4 5 Not applicable Not applicable 23 Observational Observational 11

Trials per phase (log scale)

46 of the 46 trials are tagged with Hypernatremia itself; the rest are tagged with a narrower condition beneath it.

Get the Hypernatremia report as a PDF

The PDF carries up to 50 rows of each section, where the page shows the first few, with the sources listed. Enter a work email and confirm it from the message we send, and the report follows by email.

When did Hypernatremia trials start? (20)

Shown in this order: most recent first, 1990 onwards. 2026 is partial: trials registered with a 2026 start date so far, not a full year.

Trials over time, by phase

  • Phase 1
  • Phase 1/2
  • Phase 2
  • Phase 3
  • Phase 4
  • Not applicable
  • Observational

Top of scale: 6

1999: 1 trials (Not applicable 1) 2005: 1 trials (Phase 4 1) 2008: 2 trials (Phase 4 1, Phase 3 1) 2009: 1 trials (Phase 1 1) 2010: 1 trials (Not applicable 1) 2011: 5 trials (Observational 3, Not applicable 2) 2012: 2 trials (Not applicable 1, Phase 1/2 1) 2013: 1 trials (Not applicable 1) 2014: 1 trials (Not applicable 1) 2015: 1 trials (Not applicable 1) 2016: 2 trials (Observational 1, Phase 4 1) 2017: 2 trials (Not applicable 2) 2018: 3 trials (Observational 1, Not applicable 1, Phase 2 1) 2019: 3 trials (Observational 2, Not applicable 1) 2020: 4 trials (Not applicable 3, Phase 3 1) 2021: 5 trials (Observational 2, Not applicable 2, Phase 4 1) 2022: 1 trials (Observational 1) 2023: 6 trials (Observational 1, Not applicable 4, Phase 2 1) 2025: 1 trials (Phase 4 1)

Trials registered with a start date in each year, 1990 onward, stacked by phase (complete years only; the current partial year is in the table's notes). The table below lists the same counts, most recent years first.

Trials started per year
Year Trials started
2026 (partial year) 3
2025 1
2023 6
2022 1
2021 5
2020 4
2019 3
2018 3
2017 2
2016 2

No forecast is made for this condition: it averages 2.0 trial starts a year over the five years to September, under the 5 a year the method needs.

Recruitment duration, a model prediction: 2 trials still running at the 2026-10-09 snapshot, fewer than the 5 needed for a median. Source: ClinicalTrials.gov / AACT (CTTI), public domain.

What phase are Hypernatremia trials in? (7)

Shown in this order: phase order.

Show the trials by phase as a table
Trials by phase
Phase Trials
Phase 1 1
Phase 1/2 1
Phase 2 3
Phase 3 2
Phase 4 5
Not applicable 23
Observational 11

How many Hypernatremia trials are recruiting? (5)

Shown in this order: the order a trial moves through, from not yet recruiting to unknown.

Trials by recruitment status
Status Trials
Not yet recruiting 2
Completed 24
Terminated 1
Withdrawn 5
Unknown status 14

Status as registered on ClinicalTrials.gov. Each trial is counted once.

Interventions as named in the registry (15)

Shown in this order: most trials first.

Interventions as named in the registry
Drug Trials
NaCl 0.9% NS 2
Blood Test 2
Tbl amiloride 1
Double distilled water 1
high sodium diet 1

These are the names sponsors entered on ClinicalTrials.gov that we have not matched to a single molecule. Some are drugs under a brand or code name; others are procedures, doses or arm labels.

Which serious adverse events do Hypernatremia trials report? (7)

Shown in this order: most subjects affected first. Subjects affected summed across trials, a cross-trial signal, not a rate.

Serious adverse events in this condition's trials
Adverse event Subjects affected Trials
AKI stage 2 with in-hospital treatment 1 1
abdominal pain with diarrhea with inhospital treatment 1 1
delayed discharge from hospital due to macrohematuria after kidneybiopsy 1 1
myocardial infarction 1 1
pericardial effusion with in-hospital monitoring 1 1

Which publications cover Hypernatremia? (71)

Shown in this order: major-topic papers first, then newest, then most linked to trials.

Publications
Publication Journal Year Major topic
Associations of Abnormal Fluid Status, Plasma Sodium Disorders, and Low Dialysate Sodium with Mortality in Patients on Hemodialysis. Clinical journal of the American Society of Nephrology : CJASN 2024 Yes
Hypertonic saline infusion does not improve the chance of primary fascial closure after damage control laparotomy: a randomized controlled trial. World journal of emergency surgery : WJES 2023 Yes
A review of criteria strictness in "Toxicity Grading Scale for Healthy Adult and Adolescent Volunteers Enrolled in Preventive Vaccine Clinical Trials". Vaccine 2023 Yes
Dysnatremia at ICU admission and functional outcome of cardiac arrest: insights from four randomised controlled trials. Critical care (London, England) 2023 Yes
Comparison of isotonic and hypotonic intravenous fluids in term newborns: is it time to quit hypotonic fluids. The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians 2022 Yes

Not on this page

Not measured: delivery record.

Checked, with nothing recorded for this condition: lead sponsors, prevalence, rare-disease identity, and sub-conditions in mesh.

Browse all condition evidence pages