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Condition (MeSH)

Hypocalcemia

ClinicalTrials.gov lists 94 trials for Hypocalcemia or a narrower condition beneath it. Amgen has the most among industry and government lead sponsors, with 4.

MeSH D006996 Nutritional and Metabolic Diseases C18
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Phase 1 Phase 1 4 Phase 1/2 Phase 1/2 1 Phase 2 Phase 2 11 Phase 2/3 Phase 2/3 1 Phase 3 Phase 3 12 Phase 4 Phase 4 9 Not applicable Not applicable 27 Observational Observational 29 Phase 1 Phase 1 4 Phase 1/2 Phase 1/2 1 Phase 2 Phase 2 11 Phase 2/3 Phase 2/3 1 Phase 3 Phase 3 12 Phase 4 Phase 4 9 Not applicable Not applicable 27 Observational Observational 29

Trials per phase (log scale)

94 of the 94 trials are tagged with Hypocalcemia itself; the rest are tagged with a narrower condition beneath it.

Get the Hypocalcemia report as a PDF

The PDF carries up to 50 rows of each section, where the page shows the first few, with the sources listed. Enter a work email and confirm it from the message we send, and the report follows by email.

When did Hypocalcemia trials start? (24)

Shown in this order: most recent first, 1990 onwards. 2026 is partial: trials registered with a 2026 start date so far, not a full year.

Trials over time, by phase

  • Phase 1
  • Phase 1/2
  • Phase 2
  • Phase 2/3
  • Phase 3
  • Phase 4
  • Not applicable
  • Observational

Top of scale: 8

1997: 1 trials (Observational 1) 2002: 2 trials (Phase 3 1, Phase 2 1) 2003: 2 trials (Observational 1, Not applicable 1) 2004: 2 trials (Phase 2 2) 2005: 1 trials (Phase 1/2 1) 2006: 1 trials (Observational 1) 2007: 1 trials (Phase 1 1) 2008: 5 trials (Observational 1, Not applicable 1, Phase 4 1, Phase 2 2) 2009: 2 trials (Observational 1, Phase 3 1) 2012: 1 trials (Phase 4 1) 2013: 6 trials (Observational 1, Phase 3 4, Phase 2 1) 2014: 8 trials (Observational 2, Not applicable 4, Phase 2 1, Phase 1 1) 2015: 1 trials (Observational 1) 2016: 3 trials (Not applicable 2, Phase 4 1) 2017: 5 trials (Observational 4, Not applicable 1) 2018: 3 trials (Not applicable 1, Phase 4 1, Phase 3 1) 2019: 6 trials (Observational 4, Not applicable 1, Phase 4 1) 2020: 8 trials (Observational 4, Not applicable 1, Phase 4 2, Phase 1 1) 2021: 7 trials (Not applicable 3, Phase 4 1, Phase 3 3) 2022: 7 trials (Observational 3, Not applicable 4) 2023: 5 trials (Observational 1, Not applicable 1, Phase 3 1, Phase 2 1, Phase 1 1) 2024: 6 trials (Observational 1, Not applicable 3, Phase 2 2) 2025: 6 trials (Observational 2, Not applicable 2, Phase 3 1, Phase 2/3 1)

Trials registered with a start date in each year, 1990 onward, stacked by phase (complete years only; the current partial year is in the table's notes). The table below lists the same counts, most recent years first.

Trials started per year
Year Trials started
2026 (partial year) 2
2025 6
2024 6
2023 5
2022 7
2021 7
2020 8
2019 6
2018 3
2017 5

Forecast of the full-year count, planned starts included, not rows of this table: about 2 trials starting in 2026 and about 5 in 2027, the average of the 24 months through September, counted as registered and carried forward. The rows of this table count trials registered so far with a start date in the year, planned starts included; the forecast looks ahead to the count for the whole year, so it is not the same measure. In backtests on conditions of this size, forecasts made part-way through the year were typically off by about 28 percent and ran about 20 percent low against the count later registered; forecasts made before the year began were off by about 39 percent and ran about 37 percent low against the count later registered. These figures rest on a few years of history (target years from 2018 to 2025, varying by figure), place each condition as it is mapped today rather than as it was then, and score against a count for the newest year that was still being revised. Only condition series were scored.

Prediction, not a registry value: median of 36 months from start to primary completion across 7 trials still running at the 2026-10-09 snapshot; registered median of 21 months across 50 trials with a primary completion typed Actual. Source: ClinicalTrials.gov / AACT (CTTI), public domain.

What phase are Hypocalcemia trials in? (8)

Shown in this order: phase order.

Show the trials by phase as a table
Trials by phase
Phase Trials
Phase 1 4
Phase 1/2 1
Phase 2 11
Phase 2/3 1
Phase 3 12
Phase 4 9
Not applicable 27
Observational 29

How many Hypocalcemia trials are recruiting? (8)

Shown in this order: the order a trial moves through, from not yet recruiting to unknown.

Trials by recruitment status
Status Trials
Not yet recruiting 4
Recruiting 8
Enrolling by invitation 1
Active, not recruiting 5
Completed 52

Status as registered on ClinicalTrials.gov. Each trial is counted once.

Which lead sponsors run the most Hypocalcemia trials? (9)

Shown in this order: most trials first. Lead sponsors the registry classes as industry, NIH, US federal, other government or network. A hospital or university the registry files as government can appear here. Sponsors it classes as academic or other are shown on the full page, because that class cannot separate an institution from a named investigator.

Lead sponsors
Sponsor Trials
Amgen 4
National Institutes of Health Clinical Center (CC) 3
Calcilytix Therapeutics, Inc., a BridgeBio company 2
Department of Medical Services Ministry of Public Health of Thailand 2
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) 2

Which drugs are being tested for Hypocalcemia? (5)

Shown in this order: most trials first. One row per drug, matched to a single molecule under all its names, ranked by number of trials.

Drugs tested
Drug Trials
Calcitriol 6
Calcium/Vitamin D 5
Etelcalcetide 4
Encaleret 2
Antacid 2

Interventions as named in the registry (10)

Shown in this order: most trials first.

Interventions as named in the registry
Drug Trials
Calcium Chloride/Calcium Gluconate 4
Dexamethasone/Dexamethasone acetate 3
CHOLECALCIFEROL 3
Transdermal Teriparatide 2
Rabbit Anti thymocyte globulin 1

These are the names sponsors entered on ClinicalTrials.gov that we have not matched to a single molecule. Some are drugs under a brand or code name; others are procedures, doses or arm labels.

Which serious adverse events do Hypocalcemia trials report? (10)

Shown in this order: most subjects affected first. Subjects affected summed across trials, a cross-trial signal, not a rate.

Serious adverse events in this condition's trials
Adverse event Subjects affected Trials
Hyperkalaemia 72 5
Pneumonia 60 6
Cardiac failure congestive 46 3
Fluid overload 44 4
Sepsis 38 3

Which publications cover Hypocalcemia? (165)

Shown in this order: major-topic papers first, then newest, then most linked to trials.

Publications
Publication Journal Year Major topic
Acquired factor XIII deficiency is associated with mortality and is not linked to hypocalcemia. Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis 2026 Yes
Camera-based near-infrared autofluorescence versus visual identification in total thyroidectomy for parathyroid function preservation: Systematic review and meta-analysis of randomized clinical trials. Head & neck 2025 Yes
Impact of autofluorescence for detection of parathyroid glands during thyroidectomy on postoperative parathyroid hormone levels: parallel multicentre randomized clinical trial. The British journal of surgery 2023 Yes
Usefulness of ICG Angiography-Guided Thyroidectomy for Preserving Parathyroid Function. World journal of surgery 2023 Yes
Effect of near infrared autofluorescence guided total thyroidectomy on postoperative hypoparathyroidism: a randomized clinical trial. European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery 2023 Yes

Not on this page

Not measured: delivery record.

Checked, with nothing recorded for this condition: prevalence, rare-disease identity, and sub-conditions in mesh.

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