Condition (MeSH)
Job Syndrome
ClinicalTrials.gov lists 12 trials for Job Syndrome or a narrower condition beneath it. National Institute of Allergy and Infectious Diseases (NIAID) has the most among industry and government lead sponsors, with 6.
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Trials per phase
12 of the 12 trials are tagged with Job Syndrome itself; the rest are tagged with a narrower condition beneath it.
When did Job Syndrome trials start? (10)
Shown in this order: most recent first, 1990 onwards. 2026 is partial: trials registered with a 2026 start date so far, not a full year.
Trials over time, by phase
- Phase 1
- Phase 1/2
- Phase 2
- Phase 3
- Not applicable
- Observational
Top of scale: 2
Trials registered with a start date in each year, 1990 onward, stacked by phase (complete years only; the current partial year is in the table's notes). The table below lists the same counts, most recent years first.
| Year | Trials started |
|---|---|
| 2021 | 1 |
| 2016 | 2 |
| 2014 | 1 |
| 2013 | 1 |
| 2010 | 1 |
| 2007 | 1 |
| 2005 | 1 |
| 2002 | 1 |
| 2000 | 2 |
| 1995 | 1 |
No forecast is made for this condition: it averages 0.0 trial starts a year over the five years to September, under the 5 a year the method needs.
Recruitment duration, a model prediction: none of the 12 trials evaluated at the 2026-10-09 snapshot is predicted and still running. Source: ClinicalTrials.gov / AACT (CTTI), public domain.
What phase are Job Syndrome trials in? (6)
Shown in this order: phase order.
Show the trials by phase as a table
| Phase | Trials |
|---|---|
| Phase 1 | 2 |
| Phase 1/2 | 1 |
| Phase 2 | 4 |
| Phase 3 | 1 |
| Not applicable | 1 |
| Observational | 3 |
How many Job Syndrome trials are recruiting? (6)
Shown in this order: the order a trial moves through, from not yet recruiting to unknown.
| Status | Trials |
|---|---|
| Recruiting | 1 |
| Enrolling by invitation | 1 |
| Active, not recruiting | 1 |
| Completed | 5 |
| Terminated | 2 |
Showing 5 of 6 statuses.
Status as registered on ClinicalTrials.gov. Each trial is counted once.
Which lead sponsors run the most Job Syndrome trials? (4)
Shown in this order: most trials first. Lead sponsors the registry classes as industry, NIH, US federal, other government or network. A hospital or university the registry files as government can appear here. Sponsors it classes as academic or other are shown on the full page, because that class cannot separate an institution from a named investigator.
| Sponsor | Trials |
|---|---|
| National Institute of Allergy and Infectious Diseases (NIAID) | 6 |
| Matinas BioPharma Nanotechnologies, Inc. | 1 |
| National Cancer Institute (NCI) | 1 |
| National Institutes of Health Clinical Center (CC) | 1 |
Which drugs are being tested for Job Syndrome? (3)
Shown in this order: most trials first. One row per drug, matched to a single molecule under all its names, ranked by number of trials.
| Drug | Trials |
|---|---|
| AMPHOTERICIN B | 1 |
| Cytoxan | 1 |
| Busulfan | 1 |
Interventions as named in the registry (7)
Shown in this order: most trials first.
| Drug | Trials |
|---|---|
| Ranitidine hydrochloride ODT | 1 |
| NDV-3A | 1 |
| CD3/CD19 negative allogeneic hematopoietic stem cells | 1 |
| Total Body Irradiation | 1 |
| SQ Fludarabine | 1 |
Showing 5 of 7 interventions.
These are the names sponsors entered on ClinicalTrials.gov that we have not matched to a single molecule. Some are drugs under a brand or code name; others are procedures, doses or arm labels.
Which serious adverse events do Job Syndrome trials report? (10)
Shown in this order: most subjects affected first. Subjects affected summed across trials, a cross-trial signal, not a rate.
| Adverse event | Subjects affected | Trials |
|---|---|---|
| Pneumonia | 2 | 1 |
| pneumonia | 2 | 1 |
| Abdominal pain | 1 | 1 |
| Adrenal insufficiency | 1 | 1 |
| Anaphylaxis | 1 | 1 |
Showing 5 of 10 adverse events.
Which publications cover Job Syndrome? (10)
Shown in this order: major-topic papers first, then newest, then most linked to trials.
| Publication | Journal | Year | Major topic |
|---|---|---|---|
| Lupus-like autoimmunity and increased interferon response in patients with STAT3-deficient hyper-IgE syndrome. | The Journal of allergy and clinical immunology | 2021 | Yes |
| Functional and structural analysis of cytokine-selective IL6ST defects that cause recessive hyper-IgE syndrome. | The Journal of allergy and clinical immunology | 2021 | Yes |
| Dominant-negative mutations in human IL6ST underlie hyper-IgE syndrome. | The Journal of experimental medicine | 2020 | Yes |
| Impaired angiogenesis and extracellular matrix metabolism in autosomal-dominant hyper-IgE syndrome. | The Journal of clinical investigation | 2020 | Yes |
| Hyper-IgE syndrome update. | Annals of the New York Academy of Sciences | 2012 | Yes |
Showing 5 of 10 publications.
Prevalence (4)
Shown in this order: jurisdiction, then disease name. Orphanet observation for the mapped ORPHA concept; the mapping relation column says whether that concept is exactly this condition or broader or narrower.
| Orphanet disease | Type | Class | Geography | Jurisdiction | Mapping relation |
|---|---|---|---|---|---|
| Autosomal dominant hyper-IgE syndrome due to STAT3 deficiency | Point prevalence | 1-9 / 100 000 | Europe | Not stated | Exact |
| Autosomal dominant hyper-IgE syndrome due to STAT3 deficiency | Annual incidence | 1-9 / 1 000 000 | Europe | Not stated | Exact |
| Autosomal dominant hyper-IgE syndrome due to STAT3 deficiency | Point prevalence | 1-9 / 100 000 | Europe | Not stated | Exact |
| Autosomal dominant hyper-IgE syndrome due to STAT3 deficiency | Annual incidence | 1-9 / 1 000 000 | Europe | Not stated | Exact |
Rare-disease identity (2)
Shown in this order: exact, broader, narrower, other.
| Orphanet disease | ORPHA code | Relation | Source |
|---|---|---|---|
| Autosomal dominant hyper-IgE syndrome due to STAT3 deficiency | 2314 | Exact | Orphanet Rare Disease Ontology (ORDO) |
| Autosomal dominant hyper-IgE syndrome due to STAT3 deficiency | 2314 | Exact | Orphadata Science knowledge files, Product 1 |
Not on this page
Not measured: delivery record.
Checked, with nothing recorded for this condition: sub-conditions in mesh.