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Condition (MeSH)

Ketosis

ClinicalTrials.gov lists 277 trials for Ketosis or a narrower condition beneath it.

MeSH D007662 Nutritional and Metabolic Diseases C18
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Phase 1 Phase 1 19 Phase 1/2 Phase 1/2 3 Phase 2 Phase 2 22 Phase 2/3 Phase 2/3 7 Phase 3 Phase 3 4 Phase 4 Phase 4 11 Not applicable Not applicable 161 Observational Observational 50 Phase 1 Phase 1 19 Phase 1/2 Phase 1/2 3 Phase 2 Phase 2 22 Phase 2/3 Phase 2/3 7 Phase 3 Phase 3 4 Phase 4 Phase 4 11 Not applicable Not applicable 161 Observational Observational 50

Trials per phase (log scale)

210 of the 277 trials are tagged with Ketosis itself; the rest are tagged with a narrower condition beneath it.

Get the Ketosis report as a PDF

The PDF carries up to 50 rows of each section, where the page shows the first few, with the sources listed. Enter a work email and confirm it from the message we send, and the report follows by email.

When did Ketosis trials start? (22)

Shown in this order: most recent first, 1990 onwards. 2026 is partial: trials registered with a 2026 start date so far, not a full year.

Trials over time, by phase

  • Phase 1
  • Phase 1/2
  • Phase 2
  • Phase 2/3
  • Phase 3
  • Phase 4
  • Not applicable
  • Observational

Top of scale: 35

2004: 3 trials (Not applicable 2, Phase 2 1) 2005: 3 trials (Not applicable 1, Phase 1 2) 2007: 5 trials (Observational 2, Not applicable 1, Phase 4 1, Phase 3 1) 2008: 2 trials (Not applicable 1, Phase 1 1) 2009: 1 trials (Phase 2 1) 2010: 4 trials (Observational 1, Not applicable 1, Phase 3 1, Phase 1 1) 2011: 2 trials (Observational 1, Not applicable 1) 2012: 4 trials (Not applicable 2, Phase 1/2 1, Phase 1 1) 2013: 7 trials (Observational 2, Not applicable 3, Phase 2 1, Phase 1 1) 2014: 9 trials (Observational 1, Not applicable 7, Phase 1 1) 2015: 5 trials (Observational 1, Not applicable 4) 2016: 10 trials (Observational 1, Not applicable 8, Phase 2 1) 2017: 13 trials (Observational 5, Not applicable 4, Phase 4 3, Phase 2 1) 2018: 14 trials (Observational 2, Not applicable 8, Phase 4 1, Phase 2 1, Phase 1 2) 2019: 15 trials (Observational 3, Not applicable 10, Phase 2 1, Phase 1 1) 2020: 24 trials (Observational 5, Not applicable 14, Phase 4 1, Phase 3 1, Phase 2 2, Phase 1 1) 2021: 18 trials (Observational 3, Not applicable 11, Phase 2 3, Phase 1 1) 2022: 35 trials (Observational 6, Not applicable 24, Phase 4 2, Phase 2 2, Phase 1 1) 2023: 27 trials (Observational 2, Not applicable 23, Phase 1 2) 2024: 28 trials (Observational 5, Not applicable 18, Phase 3 1, Phase 2/3 2, Phase 2 1, Phase 1 1) 2025: 29 trials (Observational 7, Not applicable 10, Phase 4 2, Phase 2/3 3, Phase 2 2, Phase 1/2 2, Phase 1 3)

Trials registered with a start date in each year, 1990 onward, stacked by phase (complete years only; the current partial year is in the table's notes). The table below lists the same counts, most recent years first.

Trials started per year
Year Trials started
2026 (partial year) 18
2025 29
2024 28
2023 27
2022 35
2021 18
2020 24
2019 15
2018 14
2017 13

Forecast of the full-year count, planned starts included, not rows of this table: about 24 trials starting in 2026 and about 26 in 2027, the average of the 24 months through September, counted as registered and carried forward, with about 0.7 times the starts already registered for the rest of 2026 added. The rows of this table count trials registered so far with a start date in the year, planned starts included; the forecast looks ahead to the count for the whole year, so it is not the same measure. In backtests on conditions of this size, forecasts made part-way through the year were typically off by about 15 percent and ran about 1 percent high against the count later registered; forecasts made before the year began were off by about 26 percent and ran about 20 percent low against the count later registered. The part-way figures are from forecasts that used a multiple fitted only on earlier years. These figures rest on a few years of history (target years from 2018 to 2025, varying by figure), place each condition as it is mapped today rather than as it was then, and score against a count for the newest year that was still being revised. Only condition series were scored.

Prediction, not a registry value: median of 34 months from start to primary completion across 36 trials still running at the 2026-10-09 snapshot; registered median of 14 months across 170 trials with a primary completion typed Actual. Source: ClinicalTrials.gov / AACT (CTTI), public domain.

What phase are Ketosis trials in? (8)

Shown in this order: phase order.

Show the trials by phase as a table
Trials by phase
Phase Trials
Phase 1 19
Phase 1/2 3
Phase 2 22
Phase 2/3 7
Phase 3 4
Phase 4 11
Not applicable 161
Observational 50

How many Ketosis trials are recruiting? (9)

Shown in this order: the order a trial moves through, from not yet recruiting to unknown.

Trials by recruitment status
Status Trials
Not yet recruiting 17
Recruiting 30
Enrolling by invitation 2
Active, not recruiting 7
Completed 152

Status as registered on ClinicalTrials.gov. Each trial is counted once.

Which drugs are being tested for Ketosis? (1)

Shown in this order: most trials first. One row per drug, matched to a single molecule under all its names, ranked by number of trials.

Drugs tested
Drug Trials
BMS-512148 5

Interventions as named in the registry (14)

Shown in this order: most trials first.

Interventions as named in the registry
Drug Trials
Ketone Monoester (KE) 14
Ketogenic diet 11
Glargine Insulin 6
ketone 4
Urine Analysis 3

These are the names sponsors entered on ClinicalTrials.gov that we have not matched to a single molecule. Some are drugs under a brand or code name; others are procedures, doses or arm labels.

Which serious adverse events do Ketosis trials report? (10)

Shown in this order: most subjects affected first. Subjects affected summed across trials, a cross-trial signal, not a rate.

Serious adverse events in this condition's trials
Adverse event Subjects affected Trials
Brain oedema 19 1
Congenital anomalies 6 1
Major adverse kidney event within 30 days of ED presentation 6 1
Severe Hypoglycemia 3 2
Acidosis 2 1

Which publications cover Ketosis? (145)

Shown in this order: major-topic papers first, then newest, then most linked to trials.

Sub-conditions in MeSH (1)

MeSH descendants one level down with at least one trial, most trials first.

Not on this page

Not measured: delivery record.

Checked, with nothing recorded for this condition: lead sponsors, prevalence, and rare-disease identity.

Browse all condition evidence pages